Involvement Of Mechanical Stress In Androgenetic Alopecia | Von Mises 2d Analysis Models

[Fgsfds]

Mechanical stress is downstream inflammation, DHT is upstream as always
Still a genetic diseases
Follicles are still dying when exposed to DHT Ex-Vivo/In Vitro

Is it that hard to understand ?

And they planted follicles from balding scalp onto someone's forearm. Went bald the same time as the head hair. Retards

 

[BetaBoy]

Mechanical stress is downstream inflammation, DHT is upstream as always
Still a genetic diseases
Follicles are still dying when exposed to DHT Ex-Vivo/In Vitro

Is it that hard to understand ?

This theory puts androgens front and center, the inflammation caused by mechanical stress is said to be responsible for creating an environment where by the androgen response is increased.

 

[BalderBaldyBald]

And they planted follicles from balding scalp onto someone's forearm. Went bald the same time as the head hair. Retards

This
Nothing more to say

 

[BalderBaldyBald]

By dying i meant depletion of progenitor stem cells, which is the same in the end, no way to fully reactivate those, at least with current treatments

 

[Arrade]

This
Nothing more to say

and if i transplant my dick to my armpit and it dies, that manes der GENATICS

 

[Arrade]

By dying i meant depletion of progenitor stem cells, which is the same in the end, no way to fully reactivate those, at least with current treatments

PTD DBM and VPA do that though

 

[Ayr9]

This
Nothing more to say

A 2002 study from the Orentreich Foundation for the Advancement of Science transplanted both balding and non-balding human hairs into the backs of mice. 22 weeks later, what were the findings?

The balding human hairs had regenerated just as well as the healthy non-balding hairs… and this regeneration happened in a single hair cycle.

In fact, those balding hairs continuedthickening through the duration of the study… whereas the non-balding hairs, for reasons unknown, plateaued after 17 weeks.
Even odder – the balding hairs regenerated in a single hair cycle – much faster than hair recoveries seen from finasteride in humans. To the researchers, this suggested the influence of non-androgenic factors in the recovery of those hairs. Yet that was as far as they could extrapolate.

 

[BalderBaldyBald]

A 2002 study from the Orentreich Foundation for the Advancement of Science transplanted both balding and non-balding human hairs into the backs of mice. 22 weeks later, what were the findings?

The balding human hairs had regenerated just as well as the healthy non-balding hairs… and this regeneration happened in a single hair cycle.

In fact, those balding hairs continuedthickening through the duration of the study… whereas the non-balding hairs, for reasons unknown, plateaued after 17 weeks.
Even odder – the balding hairs regenerated in a single hair cycle – much faster than hair recoveries seen from finasteride in humans. To the researchers, this suggested the influence of non-androgenic factors in the recovery of those hairs. Yet that was as far as they could extrapolate.

Agreed, unfortunately we are not immunodeficient mice, but humans with an immune system

This study just demonstrate that immune system is an active part of Androgenetic Alopecia (at least on mice)

 

[BalderBaldyBald]

PTD DBM and VPA do that though

So ? Still not enough apparently

 

[Arrade]

So ? Still not enough apparently

Does 1mg of finasteride not work?

 

[Ayr9]

Agreed, unfortunately we are not immunodeficient mice, but humans with an immune system

This study just demonstrate that immune system is an active part of Androgenetic Alopecia (at least on mice)

Yea we are unlucky with hairs.
But I wont throw out this fibrosis theory totally.
By believing this fibrosis and calcification theory people in the microneedling thread is regrowing hair and they are all either got bad sides from fina or didnt tried it

 

[abcdefg]

And they planted follicles from balding scalp onto someone's forearm. Went bald the same time as the head hair. Retards

Is the reason for this from circulating systemic DHT levels, or was the hair already triggered when it was in the scalp and already marked to die by androgens in the scalp so that once moved it just kept dying on its own? Once a hair is affected by DHT we dont know if DHT even needs to be present still or if the giant complicated cascade of events kills the hair off slowly independently of DHT do we?

 

[Arrade]

Is the reason for this from circulating systemic DHT levels, or was the hair already triggered when it was in the scalp and already marked to die by androgens in the scalp so that once moved it just kept dying on its own? Once a hair is affected by DHT we dont know if DHT even needs to be present still or if the giant complicated cascade of events kills the hair off slowly independently of DHT do we?

heheheah

 

[alibaba92]

Agreed, unfortunately we are not immunodeficient mice, but humans with an immune system

This study just demonstrate that immune system is an active part of Androgenetic Alopecia (at least on mice)

Does it imply that JAK inhibitor may work since that drug suppress immune system for AA ?

 

[Fgsfds]

Is the reason for this from circulating systemic DHT levels, or was the hair already triggered when it was in the scalp and already marked to die by androgens in the scalp so that once moved it just kept dying on its own? Once a hair is affected by DHT we dont know if DHT even needs to be present still or if the giant complicated cascade of events kills the hair off slowly independently of DHT do we?

Yeah because then dutasteride would be ineffective yet it has like a 95% response rate. God I hate this forum.

 

[BalderBaldyBald]

Is the reason for this from circulating systemic DHT levels, or was the hair already triggered when it was in the scalp and already marked to die by androgens in the scalp so that once moved it just kept dying on its own? Once a hair is affected by DHT we dont know if DHT even needs to be present still or if the giant complicated cascade of events kills the hair off slowly independently of DHT do we?

If you stop exposing follicles to DHT, situation stop.
Period

Does 1mg of finasteride not work?

Still not enough
People without 5AR never go bald, finasteride is a poor designed drug, blocking androgen receptors with antagonists will be a better treatment, if it ever passes clinical trials

And btw they don't have brain fog, or retarded, strange isn't it ?

 

[BalderBaldyBald]

Does it imply that JAK inhibitor may work since that drug suppress immune system for AA ?

Don't know, immune response is surely not be the only factor here
Hair follicles from balding area have multiple abnormous characteristics (scalp excluded)

Most notable one is that balding follicles have much more androgen receptors than those from donor area

 

[Ayr9]

Yeah because then dutasteride would be ineffective yet it has like a 95% response rate. God I hate this forum.

See dutasteride also dont work for some..See the the post of @UnknownT in antiandrogens forum

 

[Ayr9]

Don't know, immune response is surely not be the only factor here
Hair follicles from balding area have multiple abnormous characteristics (scalp excluded)

Most notable one is that balding follicles have much more androgen receptors than those from donor area

At all not true...I lose hair like a women...My hairline is nw1-nw1.5 but I lose from inside of temples and everywhere on the scalp...From the back to front...But most affected are crown-vertex connection point and inside the temples..
And those scalp regions are insanely thick compared to my sides and back

 

[Arrade]

If you stop exposing follicles to DHT, situation stop.
Period



Still not enough
People without 5AR never go bald, finasteride is a poor designed drug, blocking androgen receptors with antagonists will be a better treatment, if it ever passes clinical trials

And btw they don't have brain fog, or retarded, strange isn't it ?

You do realize the people without 5AR resume normal body function when they hut puberty, right?
They literally dont have a gender/masculine identity until then, something I wouldnt choose for myself