Recent content by ham373

I attach below a copy of an email from the medicine regulatory body in the UK - the Medicines and Healthcare products Regulatory Agency (MHRA) who are responsible for licencing drugs, issuing warning and guiding physicians and patients to side effects. They are pursuing a review of the safety...

Fanjeera - you seem to really, really dislike the idea off DHT being one means of a feedback mechanism forthe HPG axis. I have to say I appreciate your critical reading as this is helpful in gathering all the details together.So thanks for giving me a grilling one-man peer review. For the...

I take your point nottool. It is true that finasteride doesn't block 100% of anything and I think it seems certainly true that it does not have bad effects for everyone - while on it or after coming off it - but it does seem to affect a portion of people quite badly on it and afterwards. In...

Dihydrotestosterone is a more androgenically potent derivative of testosterone (which means it acts more strongly on androgen receptors - responsible for many of the male-defining properties of hormones - determining deepness of voice, hair growth, prostate development and function etc), while...

I think this may be right nottoolanymore - with this idea in mind, a slow tapering off might give your androgenic system time to recalibrate itself to new levels of hormones without the big whack you get in a couple of weeks of coming off it

Thanks for taking an interest. Mr patches - did you ever use finasteride/try tapering? What made me think about this issue was the period of resolution of symptoms that a lot of men report when coming off finasteride. This makes me think the use of the word 'persistent' to describe the side...

I'm going to expand on 3. first because this will explain why tapering might do anything at all: I apologise for the endocrinology 101 stuff but it's important: The most studied hormonal axis in man is the hypothalamic-pituitary axis (HPA axis) and it acts as a good model for other axes like...

You should do a slow taper (slower than almost everyone considers doing). This has a very good chance of reducing the chance of post-finasteridesyndrome. Apart from requiring patience there is no down side. The short summary: 1. Very small doses of finasteride(like 0.04mg) inhibits DHT quite...

You should do a slow taper (slower than almost everyone considers doing). This has a very good chance of reducing the chance of post-finasteridesyndrome. Apart from requiring patience there is no down side. The short summary: 1. Very small doses of finasteride(like 0.04mg) inhibits DHT quite...

Life isn't exactly as promised in the movies is it. I would say 1) Yes, I would absolutely taper off in this way. It is is irritating. It makes the most sense to avoid PFS. 2) When you say it has no effect on you whatsoever - does this mean it hasn't stopped hair loss at all? Also no side...

Finasteride is very potent ininhibiting 5-alpha reductase (5AR) as shown in a number of studiesshown below. 2 main facts emerge from this i) 0.04mg/day inhibits DHT almost asmuch as 1mg/day ii) effective doses are much lowerdoses than most people consider (this also informs tapering off thedrug...

Do not stop finasteride cold turkey! You should do a slow taper (slower than almost everyone considers doing). This has a very good chance of reducing the chance of post-finasteridesyndrome. Apart from requiring patience there is no down side. The short summary: 1. Very small doses of...

I have very good reasons to suggest that a slow tapering (slower than almost everyone considers doing) has a good chance of reducing the chance of post-finasteride syndrome. Apart from requiring patience there is no down side. The short summary: 1. Very small doses of finasteride (like...

That sounds like a bad situation, James. You should probably go to a doctor to do some blood tests to see if your hormone levels are abnormal. This can help define what the issue is and allow for further treatments. You should also put in a record of your problems to the drug regulatory body...

If you want to reduce your dose of finasteride you have to be aware of how potent small doses can be as seen in the following graph.This graph shows daily dosing of different doses of finasteride (from 0.04mg up to 1mg) for 14 days achieve nearly the same level of DHT inhibition. You can see...