Recent content by klooop

Wow, he even contacted one of the responsible people of that Avodart study and got a response - not bad. As a matter of fact, I am also on brand name Avodart and my plan was to do exactly as he was doing: up to 2.5mg per day and recheck DHT. I also posted that issue to reddit, where a few...

Very interesting. Afaik, that hasn't been documented in the scientific literature yet - my bet is on an alternative/backdoor pathway to DHT. I already got an appointment for more blood work next week, but I still need a strategy how to correctly identify those alternative pathways. IF finasteride and...

No change in that regard, if there was a change at all, libido is a bit reduced (Probably nocebo effect at work though)

Not necessarily. Both men and women have breast tissue. Afaik, Prolactin and Estrogen are responsible for gyno and in turn growth of that tissue. At least E2 is increased by Dutasteride (by increasing Free Testosterone and thus the amount that can be aromatized) Certain foods and drinking...

I expect whole genome sequencing to be cheaply available within the next 24 months. I might get that done and check the relevant sections of my genome for variants of 5AR and 3HSDB1 and other important proteins and enzymes.

There are two plausible possibilities for my DHT levels: 1. Overactivity of 5ar + genetic mutation of the 5ar-allele (VERY improbable, because inhibiting 5ar-conversion via finasteride showed a drastic increase in T and E2) 2. Adrenal overactivity (alternative synthesis of DHT) I will get all of those...

Unfortunately not, didn't get that tested on my last test. Right?! Afaik, a case like this hasn't been documented in the scientific literature yet.

None at all. No itchy/painful nipples. I guess the ratio of androgens to estrogens is responsible for me not getting gyno. Just imagine how much androgenic effect my DHT has on the breast tissue. The bit of estrogen just can't compete with that.

I just wrote a post concerning my apparent immunity to 5ar-inhibitors, especially Finasteride. Finasteride had even increased my DHT levels after 4 weeks. https://www.gourmetstylewellness.com/interact/threads/dht-levels-after-4-weeks-of-finasteride-and-8-weeks-of-finasteride-4-weeks-of-dutasteride.121754/

Follow-Up to: https://www.gourmetstylewellness.com/interact/threads/1-month-on-finasteride-no-change-in-dht-levels.120933/ Hair state: Early stage diffuse thinning, more pronounced at temples. I got Testosterone, Estradiol and DHT measured right before my first pill of Finasteride and 4 weeks in (5mg...

Well, Finasteride yes, but if it increased Estradiol that much, it essentially had to increase Free Testosterone and that would be due to actual inhibition of 5ar. So that should actually be evidence enough for Finasteride to be able to attach to my 5ar - I can't fully explain the whole thing...

As @katalan33 said, my E2 increased significantly, so it's at least doing something. Could this be backdoor synthesis of DHT? Shouldn't finasteride lower DHT significantly within a few days (essentially after the first dose)?

Would that really make a difference? Would that potentially avoid rapid metabolization in the liver by CYP3A4?

I got a prescription as I said and got the pills from a reputable pharmacy in central Europe. I already thought about some enzyme/genetic difference - welp. I don't take any other medication, so I can rule that possibility out at least. Will definitely see a doctor. BUT Finasteride has to have...

After experiencing overall diffuse thinning and some temple thinning (minor compared to the overall diffuse thinning), I got a prescription for Finasteride 5mg which I split into fourths. Have been taking 1.25mg every day for a bit over a month now. I got a few hormone level checked before...