Recent content by Otis Mack

While I think mito dysfunction is a complicating process in Androgenetic Alopecia, I wouldn't really call it the driver. Reason: in the human male to SCID mice study, just transplanting Androgenetic Alopecia follicles on that mouse wouldn't really solve any underlying mitochondrial problems by itself. The transplant tho could...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398151/ Psoriasis is also thought to be a skin disease caused by vascular problems. (table 1) Coincidentally...benoxaprofen is 75% effective in treating psoriasis. Probably...anything that can treat psoriasis effectively(benox, IL-17...

Fibrosis is just secondary to a non-growing hair follicle. There is a cytokine involved in causing anagen which just happens to dissolve fibrotic tissue. The follicle "knows about and how" to get rid of fibrosis simply when anagen begins. Many different non-scarring forms of hair loss have...

Check out this video. I spotted something on the back of one of the untreated aging mouse(one one left) : BALDING SPOT @ about 2: 10 Watch the whole video because this is about AGING VASCULAR HEALTH. Oooooh what a coincidence the mouse is developing hair loss on his back probably where his...

My 2 cents: micro-circulation problems cause mitochondria problems maybe not in these mice but in Androgenetic Alopecia. see: https://www.healthrising.org/blog/2018/12/04/capillaries-microcirculation-chronic-fatigue-syndrome-me-cfs/ "Shungu is not alone in his belief that circulatory problems, not the...

http://www.ejdv.eg.net/article.asp?issn=1110-6530;year=2013;volume=33;issue=2;spage=63;epage=66;aulast=El-Esawy Ahouansou et al. [10] reported an elevated prevalence of hypertension among men with Androgenetic Alopecia, and it has been proposed that both phenomena may be explained by the presence of...

The gender differences on the RAAS is worth reading: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1472-8206.2010.00854.x In premenopausal women, plasma aldosterone levels are lower than in men [25], but after menopause, the difference in plasma aldosterone levels between men and women...

I want to emphasize the importance of the proposed scleroderma noted by the researchers in 1st post. Most would say the shininess of the balding scalp is due to sebum. But the problem with that is sebum levels DECLINE with age while Androgenetic Alopecia in males and females INCREASE with age. The shininess is...

Aldosterone is tough on microvasculature is the take on this and that checks alot of the boxes of Androgenetic Alopecia. The subsequent problems of Androgenetic Alopecia are first initiated by some substance which disrupts microvessels. We know aldosterone levels are higher in both male and female Androgenetic Alopecia...

I want to include this paper because it talks about scleroderma which was talked about in post 1: http://www.jpp.krakow.pl/journal/archive/06_19/articles/01_article.html Also about hair specifically: "There are some studies indicating the potential role of aldosterone and MR in hair loss...

CHRONIC metformin treatment will ___cause___ hair loss according to many who take the drug orally for Type2 diabetes. Not all...but many. Acute metformin treatment will cause autophagy but chronic usage will damage the mitochondria resulting in the hair loss. Some points: 1) some molecules...

As far as I know.... women experience skull expansion too and yet most don't begin balding to any degree until about menopause when lack of estrogens probably cause their hair loss.

Talk of VEGF and hair growth but not in Androgenetic Alopecia. https://ojrd.biomedcentral.com/articles/10.1186/s13023-019-1166-6 Due to unknown aetiology of Thromboangiitis obliterans (TAO), its effectively treating is challenging. However, angiogenesis induction is one of the acceptable treatments for TAO...

Minoxidil and male-pattern alopecia: a potential role for a local regulator of sebum secretion with vasoconstrictive effects? Kurbel S1, Kurbel B, Zanić-Matanić D. Author information 1 Department of Physiology, Osijek Clinical Hospital, Croatia. sven.kurbel@public.srce.hr Abstract Regulation of...

Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798701/ Hyperandrogenism and vascular dysfunction often coexist in women with polycystic ovary syndrome (PCOS). We hypothesized that testosterone compromises...