Recent content by paul2222

Polichem's P-3074 patent (Public) Here is a link to the google document of the patent - Click on the link to download the PDF - It's much more readable: https://patents.google.com/patent/WO2010015556A1/en - Download the PDF at -...

Since the half life of Finasteride is about 5 hours, in 24 hours, it has essentially gone through 4 or 5 half lifes. Does it build up in tissue and that's why simply measuring serum finasteride and DHT levels does not accurately gauge its longer term inhibition? Also, Polichem's P-3074 formula...

Interesting. But to the point about having a lower concentration but putting more of the formula on the scalp, would 500ml with .05% be the same as 250ml at .1%?

Hey guys, i have a few questions comments and discussion items regarding topical finasteride. P-3074 etc.. First, I saw somewhere earlier in the thread that people were discussing the dosing used in the Polichem P-3074 study. The 4 doses used were 100μl, 200μl,300μl,400μl With a .25%...

I agree that it's difficult to gauge how much of a role diet plays, but what I can say is that I firmly believe diet is more crucial that people give credit to for many of the disease processes in the body. https://www.thealternativedaily.com/eating-this-could-prevent-male-baldness/ Good...

Insulin resistance causes a decrease in SHBH and and follicular stimulating hormone. It also increases 5-AR activity. By lowering your SHBH you are allowing more free testosterone. Also, but increasing the 5-AR activity, you are converting more of the free testosterone into DHT. Couple that with...

It may also be linked to the body-wide inflammation caused by certain types of diets. Medication may not be the only answer.

Good morning guys. I I'm a mid 40s male and started receding in my late 20s. I started on Propecia almost 20 years ago. About 5 years ago, I had a 1400 FUE transplant with Bernstein in NY While very happy with the results, I realized that I *may* be having some side effects from Finasteride (it...

Did Hasson & Wong completely stop promoting their liposomal Finasteride? All their links are down and they no longer talk about the topical version they were touting.

What kind of topical Finasteride are you using? I wonder why more people haven't tried ru58841?

Something to consider when using Topical Finasteride. The goal is to decrease scalp DHT while minimizing serum DHT inhibition - Oral Finasteride decreases DHT levels by 70-75% on average. From some of the studies I've seen, unless you are using some type of a film agent (Chitosan as an example)...

I did quite a bit more research on this ... There have been some anecdotal stories of ALA causing hair loss, but I can't seem to find any study that shows this. Also, there is at least one ALA producer that includes biotin in it. Another interesting thing is (hopefully I remember this...

Does anybody know where we can get P-3074 in the USA? My compounding pharmacy is not able to get the Hydroxypropyl chitosan (HPCH) ... they have suggested alternatives for the vehicle such as Hydroxypropyl Cellulose NF but there is no way to know how it acts as a vehicle in terms of both...

Hey, thanks so much for the heads up. I really appreciate it. You may have saved me from a disaster! I wonder if taking biotin with it will neutralize the effects as it appears ALA can really have tremendous long term benefits for increasing insulin sensitivity. I'm going to stop the ALA for now...

It is interesting that the P-3074 formulation is a chitosan that limits systemic absorption of finasteride. In the 100 So, some interesting thigs about P-3074. First, one of the things people seem to be ignoring in the topical finasteride studies are the serum DHT inhibition. If the topical...