Go watch haircafe videos. It interferes with the RNA to stop production of the androgen receptors. Look at the studies as well. None of this is for certain until many people try it and see if it works for them. Expensive coping at this point.
Bought. Will report back in a few months. Did not buy Brotzu. No studies on that, only hype. This has been in development for many years. It specifically targets the production of the proteins that are the androgen receptors. Now if that really makes a difference is what we are 'c'oping...
"They found that glucocorticoids instruct the regulatory T cells to activate hair follicle stem cells, which leads to hair growth."
How can they find so many things that activate hair and hair loss not be cured. Cue gene map. Nasacort is glucocorticoid. So if Flonase.
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-022-00800-7
Androgenetic Alopecia mice model was used to study the cyanidins on DHT-induced hair growth deceleration.
Results
Cyanidin 3-O-arabinoside (C3A) effectively decreased DHT-induced mtROS accumulation in DPCs, and C3A reversed the DHT-induced...
This is really fascinating. Thank you for sharing your story. It appears that you grew terminal dark hairs in a slick bald area. According to you this has been slick bald for decades. I am the same age as you and have lost 2/3 of what was left of my hair in the last year. Most of that was...
I am trying to wrap my head around the photos in the OP. I've read about the DP stem cells becoming depleted and miniaturization can't be reversed, fibrosis, arrector pili detachment, etc. At what point can't hair follicles be saved? I understand the photos are during drastic body changes...
I have been diffuse thinning since 1986. Wrap your head around that. I've seen some real crap over the years. Back when I started thinning they had 30 minute infomercials for basically polysorbate 80. From all the things I have read recently, they seem to know that it is a communication...
The following study involves mice but might shed some light on the answer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054871/
In regards to hair follicle neogenesis; the triggering of the hair follicle formation doesn't appear to happen until 10-14 days after wounding. And that is in mice...
For those of you that can't use minoxidil, perhaps this study would be of interest:
Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis
https://clinicaltrials.gov/ct2/show/NCT03491267
Drug: Retinoic acid
The study team will treat skin with topical retinoic acid
If you believe their specifications, the Dr. Pen dermapens appear to range from 8000 - 18000 rpm. For what it's worth, the first session I did with ~0.8mm dermapen caused my scalp to be red for a day longer than hard 1.5mm deramrolling. I did not bleed with the dermapen (I did a lot with...
I just got a Dr Pen M8. It has the same thinner 34 gauge needles. I've used 1.5mm dermarollers many times in the past. I can tell you that the 0.8mm dermapen with 8000rpm is a delight to use versus the rollers. I did my first session today with the lowest rpm because it most closely matched...
As in my reply to pegasus2; I think that quorum sensing was the latest puzzle piece for Follica. I would have to go back through all of the data they put out to be sure. I don't remember seeing it though.
Does quorum sensing rely on Fgf9 and shh-gli signaling? Does minoxidil provide those? Not disagreeing, I just don't know. I think the quorum sensing is the newest puzzle piece for wounding?