Recent content by SomeoneHasToSayIt

The testicles produce testosterone. Most *circulating* DHT is produced (from T) in the liver, and much DHT is produced in the tissues it acts upon (e.g. skin, hair follicles, prostate, etc). DHT produced locally in the scalp is implicated in hair loss, hence topical finasteride. The extent to which...

I've been crushing tablets and mixing them in the usual ethanol/pg solution for a while now. This is a fairly straightforward, easy method, but it's also limiting in terms of ingredients and uncertain in terms of quality. What I'd like to do instead is have a compounding pharmacy mix a topical...

You can buy tablets from alldaychemist and mix it yourself.

Are these people on different forums than gourmetstylewellness.com? I'm interested in estriol, but I see very little discussion of it here. How did you settle on .5% solution for yourself, and how do you get your hands on the stuff in the US?

Not anymore.

We're certainly not, because the pharmaceutical companies have no incentives to ask questions whose answers can only hurt them. Anyway, I could go on a long rant about finasteride and all the motivated reasoning anxious balding men engage in to justify its usage, but I'll refrain lol. I agree...

This thread isn't about your neuroticism, dude.

I haven't mathed it out, but I'm quite certain that the protocol used in the study leads to significantly more systemic exposure than would 1 ml of even a far higher concentration solution to the scalp (the scalp is much less permeable than the face, and the surface area of the application would...

That was my first thought, but I think they're describing the mass of the cream and not the active ingredient. I'll confirm in a bit.

Ok, so I had a quick look at the study (turns out it wasn't free lol), and found that the PK tests were performed every two hours following the first and last applications of the cream. I've attached the plot of CB serum concentrations for anyone interested. Subjects were applying quite a lot of...

I'll have to find the full text at some point, but it sounds like there was some degree of systemic accumulation. I wonder if the drug's weakness as an AA could explain why that doesn't cause noticeable side effects for most users. And yeah, with a regimen like yours, it doesn't sound like CB...

I've read that the drug is rapidly metabolized, but how is that supported by this finding from the acne trial: "At steady-state, plasma concentrations (of CB) increased ~1.8 to 2.1 fold versus first dose with mean (coefficient of variation [CV] %) maximum plasma concentrations of 4.4 ng/mL (67%)...

Do you know of a supplier for the pure active ingredient? The study indicates that 10 mg/ml is effective, so crushing pills seems unlikely to work (too much filler).

I have a question for some of the topical mixers on here. How do you determine if two ingredients can be mixed without interacting in a negative way? Are there some basic chemistry principles that can be applied? Do you look for research? I'm curious about using CB, topical finasteride, zinc, and maybe...

That's a silly argument. There's far more genetic diversity within dogs of the same breed than between breeds, but any sane individual would consider breed a salient categorization. The same is clearly true of race (which proves its utility in medicine every day). I agree that it's not a super...