Recent content by Trax1

Ok, for this we have benzoyl peroxide, trifarotene (retinoid). Since hardened sebum = hyperexpression of sebum + dead cells \ dirt \ etc. If you'll reduce sebum level it's won't 'mutate' to comedo or anything lake that and will be easily removed during your usual washing routine And... A...

+ i want to try

So, if I got it right, article says that if sebun will be removed from Androgenetic Alopecia area, this can prevent Androgenetic Alopecia / roll back some hair ? Well, it's pretty easy, there is a proven drugs to treat acne by deciding skin sebun level. Systematic wey: Isotretinoin - used to cure Acne. Topical: Epiduo/...

So, Here you say about using of 5% Next you say about 1% What's up, you did forgot your story that you tell a few days ago, and now imagine another one ?

O_o With Homer Simpson on avatar, and male nick ? (I know a guy from Poland with name Georgie ) Hah, whatever, i really don't care is the user Georgie have sausage in the pants or not, i'm just interested in results with cetirizine, that's all.

Wtf r u want?

@Georgie Hi man, so it's more than a month since you start cetrizine, did u find any benefits ?

It inhibits PGD2 because it's COX2 inhibitor. COX2 it's source of PGD2 but also PGE2 and PGF2a (those are necessary for hair grow).

In edge of efficiency it's the same, and it's has no sense to add topical to to oral finasteride. It's more for those who has had some sides from oral finasteride (or didn't take finasteride because of fear of sides, lol) .

You didn't answer - if VPA induce CXXC5 - which cause hair loss and inhibits WNT\b - than how does result from this studies is possible (increasing WNT\b, much hair regrow) Also - where is your proofs, studies? Because for now, all your sentences look like totally unjustified ...

It's expressed as a response on activation of PGE2 receptors (1) - and PGE2 is mandatory part of normal hair grow cycle (2). 1 http://mcb.asm.org/content/26/22/8281.full.pdf 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

Hmm... If VPA induce CXXC5 protein, and CXXXC5 protein cause har lost \ stop har grow - then how could you explain this study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323655/#pone.0034152.s001?

CsA is really interesting, as for me - because it downregulates SFRP1 -> more effective WNT\b treating. But it has molecular weight 1,202.61 g/mol so it's should be useless for topical. From other side - there were few studies on topical CsA https://www.ncbi.nlm.nih.gov/pubmed/2312805 ...

http://mcb.asm.org/content/26/22/8281.full.pdf

BTW you missing the SFRP1 that also downregulates WNT\b, also as from latest Hair Congress during Androgenetic Alopecia you have excessive DP cells migration - https://www.gourmetstylewellness.com/interact/threads/ralf-paus-strategies-to-promote-vellus-to-terminal-reconversion.109789/ >> This protein, if it exists...