Recent content by triton2

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If that it works like that, the opposite should also work. i.e.: taking a huge load of steroids for a short period of time, so that I get a hypoandrogenic response and ergo end up with more hair than I'd have hadn't I taken the steroids. My intuition tells me it just doesn't work like that but...

In theory, it shouldn't because skeletal muscle barely has any 5ar activity at all. On the other hand, even if it had, Dht formed there would rapidly deactivated by 3bHSD enzyme (the C3 ketone would be hydrogenated). In practice, I'd say that lacking SNC androgen related stimulation results...

I have been taking dutasteride for over a year and there's no doubt that there's been quite a big change in my belly skin and abdominals. Before taking dutasteride, even if I was fatter than I am now, my belly wasn't so puffy. Now it's almost as if I have a fat (or water) coat over my...

I don't know where Dr. Lee pulled up the 98% figure. Even Stamadiatis study, which uses azelaic in conjunction with zinc+b6, is less optimistic and doesn't go above the 90% figure. Azelaic acid alone, if anything, should be less effective than azelaic+zinc+b6... I guess the 98% figure doesn't...

With hairloss and with everything in life... logic rules say that the one that has to prove is that which affirmates, not that who denies, but, in thois case, I'm just analizing an argument and its validity. I didn't say azelaic acid worked, what I just said was that the evidence suggesting it...

Okay, that makes sense. But, given that fact, you cannot use the fact that azelaic acid doesn't shrink the sebaceus gland to imply that it's not blocking 5ar. If azelaic acid is a potent 5ar type 2 blocker, the same rule would apply: its effectiveness wouldn't have any effect on the sebaceous...

Aren't these two statements in conflict with each other? If finasteride failed to change sebum production, that might mean that the fact that azelaic acid doesn't change it either doesn't mean that it's an ineffective antiandrogen... it's been proven that finasteride is effective at reducing dht...

I have thought that given the fact that glycerol (1,2,3-propanetriol) has one -OH group more than PPG and ergo it's more viscous, it might allow for a better spironolactone solution. This way, what about: -50% Glycerol -50% Etanol would that be a better idea than using PPG + Ethanol...

But, at the same time, due to the fact that there's less DHT, estrogen begins to be more active and produces downregulation of testosterone production. So I think it's a matter of knowing which effect is more prevalent: 1) Upregulation of the HPTA axis due to DHT lowering 2) Downregulaion of...

Thank you very much for your answer. As far as shelf life is concerned, spironolactone already has a shelf life of many years at room temp, so if you mix it and use it within two months I don't think you should need to extend it. Extending shelf life 9 times as opposed to room temp? It depends, for...

Given the fact dermabase cream is extremely thick, I find it really hard to measure a given quantity in ml. Weighing it is far easier than measuring how many ml are there. If I knew how many ml equal one gram, life would be much much easier, because all I would need to do would be weighing it...

Damage? Could you please define "damage"? If anything a 5ar-blocker (propecia, dutasteride) might prevent a prostate disease at a latter stage of your life, that's not precisely what I'd call "damage". Yeah, you can get gyno, but you aren't gonna die from gyno, specially when nowadays there are...

Why should I refrigerate it? spironolactone has a long shell life when unmixed, why would it need being refrigerated after mixed? For instance Dr. Lee sells his spironolactone cream and it's ok well after a year after buying it, and to the best of my knowledge he doesn't recommed refrigerating it, does he? Do...

I have a problem when trying to make homebrew my 5% spironolactone cream. Dermabase is extremely thick, so I just cant mix it, it's almost impossible to stir it. However, when heated, Dermabase loses consistency and becomes a liquid, in which is MUCH EASIER to mix the spironolactone powder. My question is: is...