Recent content by Yepesyellow

I’m fairly sure it’s, for all intents and purposes, dead in the water. Unless I’m mistaken, they never tested systemic dht levels, what’s the point if not to prevent systemic dht reduction?

I I associate you with negativity and keeping hopes down. I’m conflicted on this.

Almirall broke my heart on that front, I’d high hopes for it.

Cosmetically that’s pretty significant, congratulations.

I was very interested in this a while ago but as far as I can tell they’ve not bothered to demonstrate that the product doesn’t significantly reduce DHT which was the whole point of the product in the first place. It was suggested as a product that would have similar efficacy to finasteride with...

Can anyone with a little knowledge on microneedling weigh in on this? - it doesn’t really make sense to me why there’d be a difference at all. Also there was at least one poster with minor diffuse on his crown that seemed to benefit greatly from microneedling. I’ve relatively early diffuse and...

It’s difficult to deny that microneedling does something, personally I’m very interested. I think what people with negative views question is whether 1) cosmetically significant results, like the results of the poster that inspired the thread, are common 2) maintenance beyond the minoxidil...

It looks a little better to me to be honest, not radically changed but the left-side of the crown looks a little denser. Although the light does seem stronger in the first photo.

I mean it’s as good as, otherwise there’s be absolutely no point in Almirall seeking approval or even pursuing the product at all.

Agreed. The significance of Almirall’s ALM 12845 is that it is a topical formulation that reduces systemic absorption significantly and that crucially, the claim is supported by lengthy clinical trials. In the absence of clinical evidence a topical formulation is not a particularly convincing...

Almirall released the financial report for 2018 yesterday. According to the report, the anticipated filing date with the EMA for ALM 12845 (Polichem) is Q4 2019 (p32). Assuming the standard 9-12 months for approval, a release in Q4 2020/ Q1 2021 is possible. The positive is that Almirall are...

That’s right. They predicted results released within a year and a release potentially in 2020. Almirall will probably publish year end results for 2018 by the end of February/ early March, hopefully there’ll be an update in that report.

I didn’t even know they had a release date scheduled for 2018, that’d have been nice.

I agree, 2021 would be pretty unfortunate news. Assuming that Breezula is anticipated for a 2022/2023 release, a 2021 release for P-3074 almost doesn’t make sense. In my view the key indicator for a release will be finding out when they file for approval, generally that takes a year but Almirall...

I don’t necessarily have a bad feeling about it, KX2-391 is at the same stage and hasn’t yet received a brand name. That said, KX2-391 isn’t scheduled for release until 2021 which, given that it is at the same stage as P-3074, makes me worried that they aren’t planning a release for P-3074...