2 Dutas a week?

[JWM]

Taking the half-life of dutasteride into consideration, would taking one dutasteride pill on Monday and the other on Thursday be an optimal way to get 0.1 mg of the drug a week?

Thanks

 

[Sean68]

:agree:

 

[JWM]

Thank you

 

[JWM]

I must say that I have been taking dutasteride 3 times a week for the last few weeks (after being on finasteride for years) and I am not experiencing the dried out, straw like hair I did when using dutasteride ED as I did 2 years ago.

Perhaps that Andrea guy was on to something? Maybe I will even try and drop down to twice a week now as I asked in my original post.

FYI, I am also using spironolactone cream at night which I'm sure helps moisturize my scalp.

 

[Andrea]

Hello,
I think that 2 caps/week is a right dosage.
The drug works slowly at the periferic level and a massive presence in the bloodstream is not important...
This dosage is prescribed by Dr Jerry Wong (Hasson&Wong) to mantain the hair...
JWM have you ever experience hair like straw with 0,5mg daily and now with 2 caps/week it's all right?
Thanks

Sorry for my English...

 

[JWM]

Andrea

Your English is fine! Yes, the condition of my hair is better when taking dutasteride 2-3 times a week as opposed to every day.

 

[Sean68]

Hello,

This dosage is prescribed by Dr Jerry Wong (Hasson&Wong) to mantain the hair...

interesting.

 

[Nick4441]

I went from every day to every other day and currently taking 2-3 times a week. Not really seen any change but only been on the lower dose fro a few weeks so need another month or two to see..I'm desperate to try any stop the heavy loss i'm getting so thought I would try the reduction in case my body is reactin badly to it..pillow has 20-30 hairs on it every morning :freaked2: and that's before washing ...loss is really heavy..its so dissapointing so far...

 

[dut]

Taking the half-life of dutasteride into consideration, would taking one dutasteride pill on Monday and the other on Thursday be an optimal way to get 0.1 mg of the drug a week?

Thanks

Not wishing to point out the obvious but the answer to you question is NO!
However it is a good way to take 1 mg per week but i assume this is what you meant.
For a new starter you could take 15 caps (may be 1 per day) to reach the plateaux (maximum) in the body before continuing the 2 per week.
Good luck!

 

[Bryan]

For a new starter you could take 15 caps (may be 1 per day) to reach the plateaux max in the body before continuing the 2 per week.

What do you mean by "plateaux max"? You do understand that the level of dutasteride in the blood is proportional to the intake (at higher doses, it's directly proportional), right?

 

[powersam]

For a new starter you could take 15 caps (may be 1 per day) to reach the plateaux max in the body before continuing the 2 per week.

What do you mean by "plateaux max"? You do understand that the level of dutasteride in the blood is proportional to the intake (at higher doses, it's directly proportional), right?

speaking as someone who has tried it, i strongly recommend you do not take a large loading dose. 2 a week is a great dose, has been working very well for me for 2 years or more now.

 

[JWM]

Powersam

Do you use Avodart or generic? Also, what else are you using?

 

[powersam]

Powersam

Do you use Avodart or generic? Also, what else are you using?

genuine avodart from qhi. minoxidil 5% and nizoral lotion (lotion, not shampoo)

 

[dut]

For a new starter you could take 15 caps (may be 1 per day) to reach the plateau (maximum) in the body before continuing the 2 per week.

What do you mean by "plateau (maximum)"? You do understand that the level of dutasteride in the blood is proportional to the intake (at higher doses, it's directly proportional), right?

I have edited my lazy English! The standard word is Plateau with verbs/nouns/plurals etc – Plateaux, Plateaus, Plateaued, Plateauing. From online dictionaries…A region having a relatively level value and considerably raised above values on at least one side.
A period or state of little or no growth or decline: eg; to reach a plateau in one's career.
To reach a state or level of little or no growth or decline, esp. to stop increasing or progressing and then remain at a relatively stable level.

When a value is Plateauing it is close to reaching its maximum value. In the case of dutasteride at 2/week it would take 5-6 months to reach a plateau of dutasteride in the body (circa 7mg) although 90% of the effect may be achieved earlier. However if you wish to achieve this level of dutasteride in the body quickly it can be reached in 15 days whilst never exceeding the standard dose. I.e, after taking 15 caps over 15 days the 7.5mg consumed will be circa 7mg in the body.
At this stage the elimination of dutasteride in the body is equal to the gain by the further dutasteride consumed. Ie; every 3.5 days 0.5mg is eliminated and replenished by a new cap containing 0.5mg. As you know some people incorrectly call the saturated when they mean what you call 'steady state'!

 

[Bryan]

I have edited my lazy English! The standard word is Plateau with verbs/nouns/plurals etc – Plateaux, Plateaus, Plateaued, Plateauing. From online dictionaries…A region having a relatively level value and considerably raised above values on at least one side.
A period or state of little or no growth or decline: eg; to reach a plateau in one's career.
To reach a state or level of little or no growth or decline, esp. to stop increasing or progressing and then remain at a relatively stable level.

Oh, you mean the STEADY-STATE level of the drug when taking a given dose! Now I understand what you meant!

When a value is Plateauing it is close to reaching its maximum value. In the case of dutasteride at 2/week it would take 5-6 months to reach a plateau of dutasteride in the body (circa 7mg) although 90% of the effect may be achieved earlier.

Take a look at the following graph, which shows the time to achieve various percentages of steady-state, versus dose:

http://www.geocities.com/bryan50001/dutasteride3.htm

It looks to me that at a dose of a couple of Avodart capsules per week, it would take maybe a couple of months or so to get to 95% of steady-state, according to that graph.

 

[dut]

Take a look at the following graph, which shows the time to achieve various percentages of steady-state, versus dose:

http://www.geocities.com/bryan50001/dutasteride3.htm

It looks to me that at a dose of a couple of Avodart capsules per week, it would take maybe a couple of months or so to get to 95% of 'steady-state', according to that graph.

This is consistent with my xls calculations. It also depends on the half life you use. I use 35 days.

There is also another link here that i know you've seen! http://www.hairsite2.com/images/dutas_analysis.jpg
This is also consistent with a couple of months or so (3 months) to get 95% of steady state but note that the plateau appears to reach true steady-state (maximum) at 5-6 months which is very similar to my xls.

Taking 2/week reaches only 2.1mg in the body at 15 days, 95% of 'steady state' at 90 days and full 'steady state' at 150+ days. That's why i went for full 'steady state' in 15 days by taking 1/day before continuing on 2/week. I decided that i was prepared to take 2/week and wanted the full effect ASAP without exceeding 0.5mg/day. This way i got 7mg in my body at 15days instead of waiting 150days. So ineffect i followed the blue line for 15 days followed by a horizontal saw tooth just below the brown line. This is the same principle as following the pink line to get the results of the blue line sooner but the pink line needed a couple more days at max dose before backing off to 1/day. As you know this beats 1mg of finasteride and matches 5mg of finasteride.
I've been on this for 6 months and got most my lost hair back on my crown already. I've also used minoxidil 5% once per night with nizoral/Revita. I'm well pleased :jump: :jump: :jump:

 

[Bryan]

This is consistent with my xls calculations. It also depends on the half life you use. I use 35 days.

That's a big mistake. As I explained in a previous post, the half-life at only two capsules/week isn't going to be anywhere near 35 days. That will throw-off your other calculations of the time it takes to approach steady-state.

There is also another link here that i know you've seen! http://www.hairsite2.com/images/dutas_analysis.jpg

I've seen that, and I wouldn't recommend using it. It has inaccuracies in it. It was just the creation of a poster on hairsite, it didn't come from a medical journal study.

This is also consistent with a couple of months or so (3 months) to get 95% of steady state but note that the plateau appears to reach true steady-state (maximum) at 5-6 months which is very similar to my xls.

Again, I think your calculations are rather skewed, and I think a considerable portion of it may have to do with the incorrect assumptions you made about the half-life of dutasteride. Going by that graph I posted before, if 95% of steady-state is reached after a couple of months at that dose, it can't be too much later than that that a virtually full 100% is reached. I don't see how it could be another 2-3 months on top of the first two months.

 

[dut]

That's a big mistake. As I explained in a previous post, the half-life at only two capsules/week isn't going to be anywhere near 35 days. That will throw-off your other calculations of the time it takes to approach steady-state.

My calculations are based on the only published data i have. Please point me towards the illusive data that describes the relationship between half life and quantity of drug in the body, size & frequency of intake etc i will adjust my models. The data on your chart is insufficient because it assumes taking capsule sizes that dont exist. In practice you could only take less than 0.5mg/day by taking 0.5mg less frequently. Furthermore it doesn't consider the amount in the body by 'initial loading'. I can do almost anything mathematically with the algorithms!

Looking at your graph, my "guess" is that at the lower dosages you would never reach the amount of dutasteride in the body that you could do by intial loading. I.e, if the half life depends on the amount stored in the body aswell as the subsequent intake quantity and frequency.

I've seen that, and I wouldn't recommend using it. It has inaccuracies in it. It was just the creation of a poster on hairsite, it didn't come from a medical journal study.

It is similar to mine and probably makes the same assumptions. Again, show me the algorithms and i'll adjust the models for all to use.

Again, I think your calculations are rather skewed, and I think a considerable portion of it may have to do with the incorrect assumptions you made about the half-life of dutasteride.

Again.... Where are the correct assumptions?

Going by that graph I posted before, if 95% of steady-state is reached after a couple of months at that dose, it can't be too much later than that that a virtually full 100% is reached. I don't see how it could be another 2-3 months on top of the first two months.

OK here's my data for 0.5mg/day (your marked line). Rightly or wrongly I used 35 day half life. Check it out to see if it is consistent with published data. If it is consistent within the range that you have data, you may wish to believe my figures outside this range (above 90%). I dont know how to post a graph on here (advice please). Here's the Data table. Enjoy!

No. of days to reach % of max achievable dutasteride in body when taking 0.5mg/day assuming 35 day half life.
%ofmax..........Days
70..................38
80..................56
90..................84
95..................108
97.5...............126
98.75..............142
99.375............156
99.6875..........168
99.9...............179

 

[Old Baldy]

Whoa dutasteride! Maybe I've always read Bryan's chart incorrectly but with the shorter half-life of dutasteride., when taking two capsules a week, you won't get anywhere near 95% Type II inhibition?

You'll probably get a little more inhibition of Type II than finasteride. everyday but you'll get more inhibition of Type I than you'd get from finasteride. everyday?

 

[Timi]

What is with dutasteride 0,1mg Dayli?

with Dayli 0,1mg i had No sides
when i take 0,5 mg all 3days i had
2Day long big side effects

0,1mg Dayli is so good as 5mg Proscar Dayli
(dutasteride Typ1 and Typ2)

I have today dutasteride Quit (side effect)

Timi