2018

Chrisolution

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Do you guys feel we will have better treatments not cures by 2018?

I mean in the past 30 years the best stuff we have is Finesteride & Minidoxil. It is kind of embarrassing.
 

Captain Hook

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Hopefully things will be looking up in terms of treatment efficacy when/if Kythera Biopharmaceuticals commercially releases setipiprant (a PGD2 receptor antagonist with a very favourable side effect profile)
 

Rudiger

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It's kind of freakin annoying, isn't it? The same big 2 have been available for decades, apart from nizoral and dutasteride I don't think anyone really takes anything else seriously.

When I noticed hair loss over 10 years ago (28 now) I figured, hey, it's 2005 or whatever, something concrete with guaranteed results has to turn up soon- I won't reach my 30's and have to worry about foam or little pills with probably side effects (or at least I thought so at the time).

Then once I started getting into doing something about it 5 years ago it's just become more apparent that it's not as easy as I had hoped. Actually I think most people would be shocked the efforts we go to in order to maintain hair or grow more, surely there's a proper treatment out there that doesn't involve paying an average annual salary after tax and cost of living, to go ripping an inch of skin off the back of your head and possibly all for nothing?

Nope. It's not out there.
 

Notcoolanymore

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Don't get your hopes up. I had the same line of thinking that h.l. had. When I started balding at 22 I thought: "By the time my hair gets really bad we will have a cure for sure". Well fast forward 17 years and we still have the same meds and wigs. All these future cures...I will believe it when I see it.
 

Dench57

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Anyway, it's always better to be born late :\ teenagers of today will def have a cure by the time they start balding.

Yeah I think we'll be one of the last generations to experience it tbh. In 10-15 years we'll have a maintenance drug with better safety and efficacy than finasteride I'm sure.
 

TransientHair

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I'll be surprised if there is a better treatment than Finasteride in ten years. Even if a better treatment is released will people use it? Finasteride in the grand scheme of things is very safe and effective, and yet a large amount of men still continue to bald to this day.
 

Rudiger

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I'll be surprised if there is a better treatment than Finasteride in ten years. Even if a better treatment is released will people use it? Finasteride in the grand scheme of things is very safe and effective, and yet a large amount of men still continue to bald to this day.

OK, so imagine you're new to this hair loss treatment lark, you hear about finasteride being the most popular and effective treatment, time to buy some surely?!

But before that let's just have a quick google for the most popular brand, Propecia, to make sure there's no nasty sides, and without even clicking anything you get:

Less serious side effects may include:

  • impotence, loss of interest in sex, or trouble having an orgasm;
  • abnormal ejaculation;
  • swelling in your hands or feet;
  • swelling or tenderness in your breasts;
  • dizziness, weakness;
  • feeling like you might pass out;
  • headache;
  • runny nose; (would anyone even be reading this far?)
More items...


And I re-iterate how this says LESS serious side effects, who could even imagine what the actual serious ones are? Even though there aren't any, those are it. I mean do Hair Transplant centres pay for this kind of google advertising? (serious question). It may not take THAT much understanding and digging to know that the above is bull****, but I only found that out here- after years of putting off the idea of finasteride because of all the supposed permanent debilitating side effects. And every day you'll see people posting on here talking about being in the exact same frame of mind, and who can blame them when this false idea is widely promoted.

But that's a big answer as to why so many continue to go bald, or get treatment. Besides plenty of people get no results, and only some get hair growth, it's a lot of effort and money, and time, to possibly get nothing, so for a lot of people who lean towards being indifferent/more comfortable in their baldness (plenty of men like this exist if you can imagine outside this forum) it isn't worth the hassle.

I mean it's hardly the kind of cure a lot of us imagined as teens a decade or so ago. The point is that we haven't come very far in a long time.

finasteride is hardly like a mainstream drug that everyone is expected to use once they start receding in their teens or early 20's, I'd say most people who go on it probably do a lot of research first. My idea of the great cure that would come along, is some pill you pick up in corner shops that you take every now and then which definitely grows hair, if you shed on a towel just pop another one like it's candy. I didn't picture years of ordering this stuff and using it at the same time every day, in conjunction with other treatments.

So when this safe and 100% effective corner store candy finasteride comes along, I guarantee you 99% of men will be on it. You're right that it's not THAT big of a deal but that's now you're used to it, but getting into it feels like a lot of hassle at first.


I don't know if I'd be so sure it's happening as easy as that, but hey, I'm open minded. Sceptical too, but who knows.
 

Dench57

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^ You think popping a finasteride pill everyday is a hassle? Pray you don't have to turn to experimentals.
 

TransientHair

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OK, so imagine you're new to this hair loss treatment lark, you hear about finasteride being the most popular and effective treatment, time to buy some surely?!

But before that let's just have a quick google for the most popular brand, Propecia, to make sure there's no nasty sides, and without even clicking anything you get:

Less serious side effects may include:

  • impotence, loss of interest in sex, or trouble having an orgasm;
  • abnormal ejaculation;
  • swelling in your hands or feet;
  • swelling or tenderness in your breasts;
  • dizziness, weakness;
  • feeling like you might pass out;
  • headache;
  • runny nose; (would anyone even be reading this far?)
More items...


And I re-iterate how this says LESS serious side effects, who could even imagine what the actual serious ones are? Even though there aren't any, those are it. I mean do Hair Transplant centres pay for this kind of google advertising? (serious question). It may not take THAT much understanding and digging to know that the above is bull****, but I only found that out here- after years of putting off the idea of finasteride because of all the supposed permanent debilitating side effects. And every day you'll see people posting on here talking about being in the exact same frame of mind, and who can blame them when this false idea is widely promoted.

My point is that if mass hysteria can surround Finasteride even though it is generally a very safe drug then who's to say the same won't happen for the next big thing. I think at this point people are going to associate drugs that treat hair loss with Finasteride's side effects, heck I've seen quite a few people saying that topical Minoxidil has given them sexual side effects.
 

Wolf Pack

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Yeah I think we'll be one of the last generations to experience it tbh. In 10-15 years we'll have a maintenance drug with better safety and efficacy than finasteride I'm sure.

Can you get a better maintenance and user friendly treatment than Finasteride? I don't think so. I mean we are obliterating DHT, which is right at the start of the cascade. Safer treatments may happen. Even then finasteride is pretty safe.

I like it when DHT is the enemy, none of this fancy PG stuff for me :whistle:

What may come out one day is a better regrowth treatment. I don't mean thickening of miniaturised hairs, but real terminal growth on a bald shiny area.

Transplants and finasteride are my favourite treatments :)
 

Dench57

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Can you get a better maintenance and user friendly treatment than Finasteride? I don't think so.

Not at the moment you can't. But in 10-15 years, I don't see why not. A treatment that would mean hairloss forums like this won't need to exist.
 

Notcoolanymore

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Cost? How many guys will be able to afford this? Propecia will run you close to $100. How much will seti cost? Most will be excluded by the price alone.


And yes the sides scare will happen with Seti also. It will just take one guy to claim he can't get a hard on anymore and the cycle will start from there.
 

Dench57

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Cost? How many guys will be able to afford this? Propecia will run you close to $100. How much will seti cost? Most will be excluded by the price alone.


And yes the sides scare will happen with Seti also. It will just take one guy to claim he can't get a hard on anymore and the cycle will start from there.

I've no idea, I don't see why it should be much more than Propecia if/when it gets released in a few years. It seems cheap enough to synthesise at this extremely early stage. Obviously much more than Propecia but what do you expect, it's a research compound right now.

I'm sure there will be side effects but I cannot see how they will be as bad as 5ARi sides when you're selectively inhibiting one downstream PG receptor rather than knocking out an entire androgen. I may well be wrong but in theory that seems extremely unlikely.
 

Wolf Pack

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Prostaglandin inhibitors generally have more effects on the cardio, renal system. Hepatic too. I don't know about Seti, but generally speaking. But as long as it's not ED people will be happier and less frightened lol. If finasteride is cheaper, I would stay with it due to no sides. DHT is a pretty useless hormone in adults, you still have enough of it left over on finasteride -I know some people will disagree and that's fair enough. It remains to be seen whether Seti is more effective than finasteride - I will wait to see trials on thousands of patients first. Look at the finasteride trials, you can maintain for a decade. Your probability of hair loss is like less than 0.04 (iirc) over the next 10 years IF you responded well in the first year. Add in transplants with good donor hair, it shouldn't be an issue. Of course everyone has a different situation for whatever reason.

It also seems more logical to me to inhibit the first part of the cascade as it stops the domino effect better. This is an androgen initiated problem. As we know, those that don't have type 2 dht genetically, don't get male pattern baldness in the first place.
 

Wolf Pack

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But you are totally contradicting yourself. finasteride does exactly the same thing as Seti but more. finasteride inhibits a lot more Prostaglandins, by inhibiting the source: DHT.

That's like saying you support banning hand guns but are in favor of machine guns. :ermm:

I was talking about the current prostagladin inhibitors on the market, their side effects. They all belong to the same family. Not this specific Seti one. I did say I don't know about Seti. However, I did see a brief presentation on Seti and they did explore the possibility of hepatitis and raised LFTS, so I am not mad for thinking that.

You clearly are very invested in this, I usually find it's a certain type of character.

You're also contradicting yourself. You said Seti is more effective yet finasteride inhibits more PGs according to you :)

I don't think I have said anything stupid. Waiting to see how Seti does in a large and long trial with a placebo group is the best way. Until then - speculation.
 

Notcoolanymore

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As long as I can't get ED from seti, then I am fine with taking it. I can deal with anything else, but the risk of ED is just too much for me to handle.
 

Notcoolanymore

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Waiting to see how Seti does in a large and long trial with a placebo group is the best way. Until then - speculation.

Who needs trials? There are plenty of guys on gourmetstylewellness.com that say it will work so that is all the convincing I need.
 

Wolf Pack

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As long as I can't get ED from seti, then I am fine with taking it. I can deal with anything else, but the risk of ED is just too much for me to handle.

LMAO. You have said something very similar in the past and I wanted to use it as a signature. This will be it now :) It's funny because finasteride interacts with no drug, no major system of the body, it just inhibits an enzyme which really does nothing except T to DHT. I know people will bring up those other biochemicals to do with mood (neurosteroids) but it's no biggie as the trials showed.

But yes, doesn't matter if major systems of the body go to ****, as long as my boobs and penis work.

Sides exist for all medications. PGD2 I am sure is found in mast cells all across the body. It still needs to be metabolised by the liver and kidney.

- - - Updated - - -

Yes it's more effective because it targets the baldness proteins like targeted shots (Seti) instead of machine gunning everything to get to the PGs (finasteride). Which ultimately reduces side-effects.

Perhaps, lets see. I don't know about you, but when I have a fly in my house, I want to nuke the whole place up. I don't want to use an insecticide.



Who needs trials? There are plenty of guys on gourmetstylewellness.com that say it will work so that is all the convincing I need.

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