AA driving me crazy

J

jayden kauffman

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This is my 3rd shot on this post, so here we go.

I was diagnosed with subacute alopecia areata, now my questions seem to not get answered. Like why did my hair loss go on for 3 years? And others 3 weeks to 3 months? Also, why do i have little to no armpit hair? Why is my pubic hair thinning out as well? And why won't these stubby hairs grow more than a quarter inch? Here is my scalp biopsy diagnosis

Diagnosis: ALOPECIA WITH SPARSE PERIVASCULAR DERMATITIS AND PERIFOLLICULITIS.

Note: Given catagen/telogen shift of approximately 40%, subacute ALOPECIA AREATA is considered as more likely.

Now, my dermatologist tested for Androgenetic Alopecia and AA.
5 months of cortisone injections and no results. this hair loss is pissing me off like no other.

Any suggestions on what I should do?
 
T

TD500

Experienced Member
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Aside from the standard treatments only other thing I read about was ruxolitinib which is a bone cancer treatment or something.

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Nevermind Dikek already posted it
 
G

galil

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Successful Treatment of Alopecia Areata with Topical Calcipotriol


Alopecia areata (AA) is an inflammatory hair loss of unknown etiology. AA is chronic and relapsing, and no effective cure or preventive treatment has been established. Vitamin D was recently reported to be important in cutaneous immune modulation as well as calcium regulation and bone metabolism. It is well known that areata is common clinical finding in patients with vitamin D deficiency, vitamin D-resistant rickets, or vitamin D receptor (VDR) mutation. The biological actions of vitamin D3 derivatives include regulation of epidermal cell proliferation and differentiation and modulation of cytokine production. These effects might explain the efficacy of vitamin D3 derivatives for treating AA. In this study, we report a 7-year-old boy with reduced VDR expression in AA, recovery of whom was observed by topical application of calcipotriol, a strong vitamin D analog.

Our patient with AA did not respond to various treatments, including topical and intralesional corticosteroids. We tried calcipotriol as another treatment option to stimulate impaired function of VDR in AA. VDR is not expressed in only epidermal keratinocytes, but it is also found in the outer root sheath keratinocytes and dermal papilla cells of hair follicles1. Furthermore, the enzyme for synthesizing 1, 25(OH)2D3, 25-hydroxyvitamin D-1a-hydroxylase, is expressed in both the basal layer of the epidermis and the matrix cells of hair follicles in the dermis, suggesting that keratinocytes in hair follicles both make and respond to their own 1,25(OH)2D316.
In this case, we have shown that AA presents with reduced VDR expression and that topical application of a vitamin D analog might be another treatment option upon failure of conventional therapies. To our knowledge, this is the first report of the successful treatment of AA with topical application of a vitamin D analog. Further studies are needed to assess the effectiveness of this therapeutic modality in a greater number of patients with AA.

Whole study and pics here
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412244/

edit, daivonex scalp lotion has calcipotriol, I've read some very few ppl having some improvement with it
 
Swoop

Swoop

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Start reading this review; http://www.sciencedirect.com/science/article/pii/S2210836X13000237.

Discuss with your doctor other options if corticosteroids are not effective enough if you suffer from AA. Aside the options mentioned in the review more treatment options are possible too though that have had success.




1-s2.0-S2210836X13000237-gr5.jpg
 
J

jayden kauffman

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