Bryan: help brewing spironolactone with DERMABASE

[triton2]

I have a problem when trying to make homebrew my 5% spironolactone cream. Dermabase is extremely thick, so I just cant mix it, it's almost impossible to stir it. However, when heated, Dermabase loses consistency and becomes a liquid, in which is MUCH EASIER to mix the spironolactone powder.
My question is: is there any problem with heating Dermabase? When I add my spironolactone powders to the HOT dermabase cream do you think that heat could damage them?
On the other hand, in order to heat dermabase, is there any problem doing so with a microwave?

thank you.

 

[Old Baldy]

I have a problem when trying to make homebrew my 5% spironolactone cream. Dermabase is extremely thick, so I just cant mix it, it's almost impossible to stir it. However, when heated, Dermabase loses consistency and becomes a liquid, in which is MUCH EASIER to mix the spironolactone powder.
My question is: is there any problem with heating Dermabase? When I add my spironolactone powders to the HOT dermabase cream do you think that heat could damage them?
On the other hand, in order to heat dermabase, is there any problem doing so with a microwave?

thank you.

Can't speak for Bryan but heating Dermabase is fine. While it is cooling, and still more fluid, add the spironolactone. Adding spironolactone to slightly warm cream will not damage it in any way.

The Dermabase will thicken right up. (Put it in the refrigerator after mixing the spironolactone.)

 

[triton2]

The Dermabase will thicken right up. (Put it in the refrigerator after mixing the spironolactone.)

Why should I refrigerate it? spironolactone has a long shell life when unmixed, why would it need being refrigerated after mixed?
For instance Dr. Lee sells his spironolactone cream and it's ok well after a year after buying it, and to the best of my knowledge he doesn't recommed refrigerating it, does he?
Do you really think that spironolactone's effectiveness is going to be compromised if you don't refrigerate it?

thank you.

 

[Old Baldy]

The Dermabase will thicken right up. (Put it in the refrigerator after mixing the spironolactone.)

Why should I refrigerate it? spironolactone has a long shell life when unmixed, why would it need being refrigerated after mixed?
For instance Dr. Lee sells his spironolactone cream and it's ok well after a year after buying it, and to the best of my knowledge he doesn't recommed refrigerating it, does he?
Do you really think that spironolactone's effectiveness is going to be compromised if you don't refrigerate it?

thank you.

One trick to making creams is to cool them "quickly", it thickens them up better than letting them sit at room temperature to "harden". Well, at least that's what I've learned from making my own creams.

Unless you are a professional, spironolactone. concoctions are usually fairly unstable. Just to play it safe I (not being a professional) refrigerate spironolactone. concoctions. Don't really know if it is necessary though.

Dermabase might have enough stabilizers, etc., to allow spironolactone. to be stored at room temperature for a long time? I just don't know, so I play it safe with pretty much all of my concoctions.

Refrigeration generally extends the shelf life of cosmetics, drugs and vitamins. (And refrigeration of spironolactone. won't hurt it at all from what I've read.)

Do a quick read of this article by a professional: (Refrigeration in the examples extends the shelf life by 9 times on average.)

http://www.paddocklabs.com/images/PadSec_v7n3.pdf

 

[triton2]

Thank you very much for your answer.
As far as shelf life is concerned, spironolactone already has a shelf life of many years at room temp, so if you mix it and use it within two months I don't think you should need to extend it.
Extending shelf life 9 times as opposed to room temp? It depends, for instance, if you vacuum sealed spironolactone raw powders they would probably last many DECADES at room temp, I doubt refrigerating/freezing them would make much improvement.
If we are talking about other non-vacuum-sealed products or foods, yes, refrigeration would make a difference definitely.
Don't take my word for anything, I'm not an expert in chemistry!