Dutasteride questions help....

[Dani_uk]

Does anyone know:

a) How long does it take for dutasteride to build up to a steady level (and the value?, dutasteride everyday inhibits DHT ~ 90%?) if taken on Mon, Wed and Fri only?

b) What is the half life of dutasteride when taken Mon, Wed and Fri.

c) How effective is dutasteride Mon, Wed and Fri, when compared to Propecia everyday and dutasteride everyday.

Thanks in advance

 

[Bryan]

a) How long does it take for dutasteride to build up to a steady level (and the value?, dutasteride everyday inhibits DHT ~ 90%?) if taken on Mon, Wed and Fri only?

Look at the following graph: http://www.geocities.com/bryan50001/dutasteride3.htm

I penciled-in the line for the 0.5 mg/day dose. As you can see, at that level it takes about 84 days to get to 90% of steady-state, and about 110 days or so to get to 95%.

b) What is the half life of dutasteride when taken Mon, Wed and Fri.

Oh, I dunno. I'm guessing maybe around 3 to 4 weeks.

c) How effective is dutasteride Mon, Wed and Fri, when compared to Propecia everyday and dutasteride everyday.

At an average daily dose of 0.214 mg, it should be a little more effective than finasteride.

 

[neis]

Bryan,


If 0.5mg dutasteride doesn't help, what's the next move? Or generally what is the best you can do if you are considering using dutasteride?


Is it better to increase the dutasteride dose for example: to 2.5mg squeezing that last few percent of DHT out of the picture with huge amounts of systemic 5ar inhibitors and inhibiting 82% of scalp DHT vs 0.5's 55% ? OR to decrease the production of androgens(like scalp testosterone) by the adrenal glands and prevent DHT from binding to its androgenic receptor taking 200mg of oral spironolactone daily in combination with 0,5mg dutasteride? (Ignore the spironolactone side effects, Not worried about gyno from oral spironolactone at all. I will have surgery and have the glands removed.)

The first idea seems to be more logical with the the numbers(55% vs 82%) and too expensive too , but because I have recently learned that one problem with dutasteride is that while it sharply reduces DHT, it also sharply increases scalp testosterone. I believe that testosterone (in addition to DHT) plays a role in hair loss. So if you're considering using dutasteride you should be sure to use an anti-androgen also. dutasteride will reduce the amount of DHT on the scalp and the 200mg of oral spironolactone(oral anti-androgen) will help counter the scalp testosterone and also block the remaning DHT at the receptor sites. So the second idea seems to be logical too.

* Some have suggested that Oral Spironolactone can bond to the hair follicles before DHT can bind to the receptor.

So Bryan which of these two ideas would you choose? and what's the best?

 

[Guest]

Bryan,


If 0.5mg dutasteride doesn't help, what's the next move? Or generally what is the best you can do if you are considering using dutasteride?


Is it better to increase the dutasteride dose for example: to 2.5mg squeezing that last few percent of DHT out of the picture with huge amounts of systemic 5ar inhibitors and inhibiting 82% of scalp DHT vs 0.5's 55% ? OR to decrease the production of androgens(like scalp testosterone) by the adrenal glands and prevent DHT from binding to its androgenic receptor taking 200mg of oral spironolactone daily in combination with 0,5mg dutasteride? (Ignore the spironolactone side effects, Not worried about gyno from oral spironolactone at all. I will have surgery and have the glands removed.)

The first idea seems to be more logical with the the numbers(55% vs 82%) and too expensive too , but because I have recently learned that one problem with dutasteride is that while it sharply reduces DHT, it also sharply increases scalp testosterone. I believe that testosterone (in addition to DHT) plays a role in hair loss. So if you're considering using dutasteride you should be sure to use an anti-androgen also. dutasteride will reduce the amount of DHT on the scalp and the 200mg of oral spironolactone(oral anti-androgen) will help counter the scalp testosterone and also block the remaning DHT at the receptor sites. So the second idea seems to be logical too.

* Some have suggested that Oral Spironolactone can bond to the hair follicles before DHT can bind to the receptor.

So Bryan which of these two ideas would you choose? and what's the best?

BUMP....
I have the same question,

Bryan??

 

[Bryan]

Bryan,
If 0.5mg dutasteride doesn't help, what's the next move? Or generally what is the best you can do if you are considering using dutasteride?

If you don't think you're doing well enough with finasteride or dutasteride alone, the next step would be adding various topicals that you see being discussed here. I'd certainly recommend something like Proxiphen, if you can afford it, or the the OTC version Prox-N. They attack the problem from various angles that aren't touched by finasteride/dutasteride. Other products that you read about here should be helpful, too.

 

[JWM]

At an average daily dose of 0.214 mg, it should be a little more effective than finasteride.

Bryan, are you referring to the 5 mg Proscar dose per day, or the 1 mg Propecia dose per day?

 

[Bryan]

At an average daily dose of 0.214 mg, it should be a little more effective than finasteride.

Bryan, are you referring to the 5 mg Proscar dose per day, or the 1 mg Propecia dose per day?

Both.