EGCG (topical) stimulates hair growth study.

[patagonia]

For those who havnt seen it, Im copying this study Michael Barry posted on another site:

Via pubmed:


1: Phytomedicine. 2007 Aug;14(7-8):551-5. Epub 2006 Nov 7. Links
Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG).Kwon OS, Han JH, Yoo HG, Chung JH, Cho KH, Eun HC, Kim KH.
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Seoul National University Hospital, Institute of Dermatological Science, Seoul National University, 110-744 Seoul, Republic of Korea.

Green tea is a popular worldwide beverage, and its potential beneficial effects such as anti-cancer and anti-oxidant properties are believed to be mediated by epigallocatechin-3-gallate (EGCG), a major constituent of polyphenols. Recently, it was reported that EGCG might be useful in the prevention or treatment of androgenetic alopecia by selectively inhibiting 5alpha-reductase activity. However, no report has been issued to date on the effect of EGCG on human hair growth. This study was undertaken to measure the effect of EGCG on hair growth in vitro and to investigate its effect on human dermal papilla cells (DPCs) in vivo and in vitro. EGCG promoted hair growth in hair follicles ex vivo culture and the proliferation of cultured DPCs. The growth stimulation of DPCs by EGCG in vitro may be mediated through the upregulations of phosphorylated Erk and Akt and by an increase in the ratio of Bcl-2/Bax ratio. Similar results were also obtained in in vivo dermal papillae of human scalps. Thus, we suggest that EGCG stimulates human hair growth through these dual proliferative and anti-apoptotic effects on DPCs.

PMID: 17092697 [PubMed - indexed for MEDLINE

 

[Nuli]

Re: EGCG stimulates hair growth study.

This is internal green tea and not topical correct?

 

[patagonia]

Topical

 

[JLL]

They tried it both on cultured hair follicles and human scalps. See this post:

Green tea extract grows hair in vitro, may work in vivo

 

[John Yossarian]

Has anyone every tried this before? It seems pretty interesting. I might give it a shot.

 

[bababooey]

I'm willin to try as well.

Anyone know a good source of this green tea extract?
I googled and found some liquid versions but I dont know if egcg has an expiration date.

 

[JLL]

try purebulk.com

 

[GlasgowCelt]

I said it before and I will say it again. Skin needling and then appliance of topical green tea (lukewarmed) every other day does the trick.

 

[bababooey]

"does the trick" as in regrows hair?
has it worked for you?

 

[John Yossarian]

Does anyone know how where one could find Green Tea with very high amounts of EGCG? I kinda want to try it out, but I can't find anything. Thanks.

 

[chore boy]

Unless I'm missing it, where do you guys see topical application mentioned? AFAIK, in vivo has absolutely nothing to do with topical application. Someone please correct me if I'm wrong.

 

[patagonia]

Does anyone know how where one could find Green Tea with very high amounts of EGCG? I kinda want to try it out, but I can't find anything. Thanks.

Teavigo - 90% EGCG.

http://www.amazon.com/s/ref=nb_ss_gw?url=search-alias=aps&field-keywords=teavigo&x=8&y=12


you can open a few capsules and leave them in ethanol for a couple of days on closed container.

then just filter the fillers with a coffee filter or cloth.

could then add some % of distilled water to mix if you want to.

you can apply with a spray pump or dropper.

I leave the mix in the refrigerator at all times.

 

[JLL]

Unless I'm missing it, where do you guys see topical application mentioned? AFAIK, in vivo has absolutely nothing to do with topical application. Someone please correct me if I'm wrong.

In vivo = "within the living", meaning something is used on live organisms instead of a test tube. In vivo in this case could mean oral or topical treatment. As I recall, in the green tea study, they first tried it in a test tube using dermal papilla cells, and then applied it onto human scalps, topically. It doesn't say it this in so many words in the abstract, but I'm talking about the full paper.

 

[Tyler_Durden]

Is anyone trying Green Tea extract as a topical?

Would be interested to see how it is going.

 

[Fazi555]

does anyone know what is green tea extract? where can i buy this in canada. thanks

 

[CCS]

I get my 98% EGCG at www.beyondacenturyonline.com.

It is preserved much longer in distilled water. Mineral water breaks it down.
It is also better in acidic conditions. Add a drop of limon juice.
The fridge is best.
Bulk powder is super cheap, but you will never use it up anyway, and it might go bad. I'd just get the pills and break them open as needed. Stays fresh that way.
Small pills are probably 1/5 Gram. Big pills might be 1/2 gram (500mg). Should say on the bottle. That is another nice thing about pills: they tell you how much they weigh.
Get a glass container, and a glass dropper. You can find them online. Might have to pay $7 shipping for a $2 dropper, but it is a worthy investment. Just get 5 at a time. Amazon has them.
Use distilled water, ethanol, and maybe some PG. I'll use a bit of DMSO too, but it has to be pharmaceutical grade.

I advise using 2000mg 60mL. Add some drops of Lavender essential oil to the mix. It dissolves in ethanol.

 

[blaze]

CCS how is the topical EGCG going?

How do you think it actually works? That study isnt really very definite.

 

[IBM]

I said it before and I will say it again. Skin needling and then appliance of topical green tea (lukewarmed) every other day does the trick.

Did you had good results?

 

[Boondock]

^ Second that, it'd be good to hear if anyone's actually had results from green tea before any of us go about making a topical.

 

[Guest]

I'd be interested in hearing results too