Finasteride Dose Dependent Efficiency

[tjnpdx]

Can someone with a bit more experience with this than myself break down this article and explain any obvious flaws, miscalculations, or apparent errors? Would lower doses correlate to less sides? I read something about smaller doses leading to similar changes in scalp DHT but different changes in serum, and I'll post that here when I uncover it.

Here: https://tophairlosstreatments.com/best-finasteride-dose-hair-loss/

I'm about to start finasteride within the next week or two. I'd really like to know if anyone has ever used such low doses and found benefits, but I doubt I'll catch someone in this thread. Either way, please throw down some input on this.

 

[tjnpdx]

Here's the study I mentioned: http://www.jaad.org/article/S0190-9622(99)80051-6/abstract

They state:
1mg Scalp Skin Reduction: 64.1%
1mg Serum Reduction: 71.4%
.05mg Scalp Skin Reduction: 61.6%
.05mg Serum Reduction: 49.5%
Placebo Scalp Skin Reduction: 13% (lemme get one of those. AMIRITE XD)

There's a chance I'm looking at this wrong or just missing something all together. Thanks in advance for correcting me if necessary.

 

[tjnpdx]

Nobody thinks anything of this? The only thing I can imagine misinterpreting is that serum DHT needs to be reduced to the point that 1mg achieves, but it seems counterintuitive that scalp-skin DHT wouldn't be the important thing.

 

[Swiss_Tampons]

Nobody thinks anything of this? The only thing I can imagine misinterpreting is that serum DHT needs to be reduced to the point that 1mg achieves, but it seems counterintuitive that scalp-skin DHT wouldn't be the important thing.

Hey man, check the finasteride microdosing threads. This has been discussed several times before. I think it's a valuable discussion anyway.

 

[tjnpdx]

Will do. Thanks!

 

[supermusic]

https://www.gourmetstylewellness.com/interact/threads/finasterides-effect-on-scalp-dht-levels.87522/

 

[tjnpdx]

https://www.gourmetstylewellness.com/intera...od-tests-came-back-micro-dosing-works.101645/

Just get conflicting info haha

 

[tjnpdx]

Also, I asked this on an old thread, so I'm not sure if people will see it, but is it not perfectly possible to just crush the 1mg pill, take 1/20th of it (.05mg), and stick the allotted doses in veggie capsules? This whole dissolving in alcohol thing sounds like a pain in the ***.

 

[Afro_Vacancy]

Also, I asked this on an old thread, so I'm not sure if people will see it, but is it not perfectly possible to just crush the 1mg pill, take 1/20th of it (.05mg), and stick the allotted doses in veggie capsules? This whole dissolving in alcohol thing sounds like a pain in the ***.

You can dissolve 1 mg into a 60 ml minoxidil bottle.

Take 2 ml a day, so 0.033 mg of finasteride daily.

 

[tjnpdx]

You can dissolve 1 mg into a 60 ml minoxidil bottle.

Take 2 ml a day, so 0.033 mg of finasteride daily.

But the veggie capsules is perfectly fine, right? I only ask because I haven't seen anyone mention that they went this route. I have, however, seen a lot of people complain about the alcohol thing. To each his own, I guess. To me the veggie caps would be simple.

Have you ever untaken microdosing, David?

 

[Afro_Vacancy]

But the veggie capsules is perfectly fine, right? I only ask because I haven't seen anyone mention that they went this route. I have, however, seen a lot of people complain about the alcohol thing. To each his own, I guess. To me the veggie caps would be simple.

Have you ever untaken macrodosing, David?

Not finasteride, but I take the smallest RU dose of anybody.

 

[Grasshüpfer]

I think we have to understand this micordosing thing differently.
For example Desmond, one of the most experienced hairloss veterans who managed to keep his hair, was on extremely low doses of both finasteride and ru.

However I believe that the dosing is individual for each person. While one will do nicely with 0.25mg the other one needs to take dutasteride because finasteride is too weak altogether.

I recommend to go on the standard dose.

If you maintain after a year, or get sides >> lower the dose.

 

[br1]

There it is my theory:

if you are going to take it for years, say a couple decades even, I don't think small doses will do any difference in the end. Why? Because of the drug's half-life + accumulation.

See, if you take 0.5mg, the half life is 7hr. So, in 7hr you'll still have 0.25mg in your system. Another 7hr = 0.125mg and so on.. When you take your next dose, you'll still have some left in your system. And in the long run you'll reach a steady concentration of finasteride in you.

The only difference I see, is that it will take longer for you to reach the "final steady concentration"...

 

[tjnpdx]

There it is my theory:

if you are going to take it for years, say a couple decades even, I don't think small doses will do any difference in the end. Why? Because of the drug's half-life + accumulation.

See, if you take 0.5mg, the half life is 7hr. So, in 7hr you'll still have 0.25mg in your system. Another 7hr = 0.125mg and so on.. When you take your next dose, you'll still have some left in your system. And in the long run you'll reach a steady concentration of finasteride in you.

The only difference I see, is that it will take longer for you to reach the "final steady concentration"...

I'm not sure about all of this. Here they state that the differences with regular dosing and smaller doses was most noticeable in the time it took to achieve maximum inhibition. The study in the second post of this thread notes that they were given daily doses of various quantities for 42 days, which I would think would supply more than enough time for adequate accumulation to occur. I'm most concerned with the differences in serum DHT between .05mg and 0.5-1mg, as there's about a 20% difference here, while a minute difference in scalp/skin dht.

If it were to be so that when taking finasteride the doses just compounded on top of each other then wouldn't there be no reason that taking 1mg, even 5mg, everyday wouldn't eventually irradiate 100% of serum/scalp DHT through the inhibition of 5AR?

 

[tjnpdx]

I think we have to understand this micordosing thing differently.
For example Desmond, one of the most experienced hairloss veterans who managed to keep his hair, was on extremely low doses of both finasteride and ru.

However I believe that the dosing is individual for each person. While one will do nicely with 0.25mg the other one needs to take dutasteride because finasteride is too weak altogether.

I recommend to go on the standard dose.

If you maintain after a year, or get sides >> lower the dose.

Do you know what his specific finasteride dose was?

 

[Janekoman12]

I take 1.25 mg cut proscar in 4 about 6 Months Did not se so Much diffrence i upped it to 2.5 to se if does anything side wise or hairloss wise 6 Months in and still the same mambye like 10-15 strands less shedding

 

[tjnpdx]

I take 1.25 mg cut proscar in 4 about 6 Months Did not se so Much diffrence i upped it to 2.5 to se if does anything side wise or hairloss wise 6 Months in and still the same mambye like 10-15 strands less shedding

Are you fairly early into loss?

 

[Janekoman12]

Are you fairly early into loss?

I would say a 1.5 norwood with diffuse thinning, its the diffuse part that kills My hair rather Go bald with nws with Thick hair around

 

[Janekoman12]

Are you fairly early into loss?

I am shedding short thin hair and some medium short hair and very few Thick short hair or medium lenght in one day but 75% short dht dmaged hair

 

[Janekoman12]

Side wise i belive eather your body Can take finasteride or it dont Can take it and no point micro dose it side wise