hairline and type I enzyme

[PJ Worshipper]

Is there medication that blocks the type I and II enzymes. Propecia blocks type II for the vertex right? is type I for the hairline? if there is medication for both where can I get it and what is it? And does it work? thanks.

 

[j25]

It's not that black and white.. For some people propecia works for the hairline as well, but for the vast majority it works way better on the vertex. Halting frontal hairloss is just very very tough.

 

[Dinzy]

Types don't correspond to areas of the scalp

 

[jeffsss]

Types don't correspond to areas of the scalp

i've heard otherwise.

 

[Boru]

Is there medication that blocks the type I and II enzymes. Propecia blocks type II for the vertex right? is type I for the hairline? if there is medication for both where can I get it and what is it? And does it work? thanks.

Dutasteride, available from various sources, including Prague.
I'm waiting until it is available on prescription here, as the finasteride (proscar) is working for me, thousands of new terminal hairs at the front and top. I was a full shiny Norwood a year and a half ago, now I have the beginnings of a modest head of hair. They are just rather small and thin, need to go through another few cycles to get stronger.
Boru

 

[Bryan]

Types don't correspond to areas of the scalp

i've heard otherwise.

Dinzy is almost certainly correct: there's no scientific evidence that balding in different areas of scalp is caused by different types of 5a-reductase. That's just a theory that gets tossed around occasionally on hairloss sites by some guys in an attempt to explain why finasteride didn't work well on their hairlines.

Bryan

 

[michael barry]

Bryan,
I seen on Loren Pickarts site that he thought the type I enzyme located in the skin sebocytes/areas close to follicle production of DHT might affect follicles more than DHT in bloodstream.
Ive often wondered if blood flow from blood stream is just better in mid-anterior, and vertex where propecia performs best or whether there are just so many more androgen receptors in the front that only slight amounts of DHT can minaturize hair here?

 

[Bryan]

Bryan,
I seen on Loren Pickarts site that he thought the type I enzyme located in the skin sebocytes/areas close to follicle production of DHT might affect follicles more than DHT in bloodstream.

I suppose that's possible; however, I don't really think that's saying very much, since I don't think that serum DHT has all that much of an effect on hairloss.

Ive often wondered if blood flow from blood stream is just better in mid-anterior, and vertex where propecia performs best or whether there are just so many more androgen receptors in the front that only slight amounts of DHT can minaturize hair here?

I don't think blood flow has much to do with balding, so I think that's a moot point. It seems likely that the front part of the scalp is indeed more sensitive to androgens for whatever reason(s), and that makes it more difficult to stop balding at that location.

BTW, have you ever heard what Dr. Proctor says about the "mysterious" apparent growth inhibitor in the frontal part of the scalp? He says that SOMETHING is there, centered in a gradient around the eyes which inhibits hair growth, and probably contributes to the difficulty of stopping frontal balding.

Bryan

 

[michael barry]

Bryan,

Ive not seen where Proctor said that but that is fascinating (and depressing). Im looking for a topical anti-androgen to add to my little routine, but am afraid of the zinc and azaleic acid in Revivo. Have considered spironolactone or even progesterone (in hopes of just gumming up receptor sites).

On Pickart's skinbio.com he (Pickart) goes on about the microcapillaries at the base of the follicle not re-enlarging enough at the beginning of anagen phases not getting blood to the papilla as a problem, not cranial blood flow. He seems to think that that is a signifigant part of the damage DHT does to the follicle area. Who knows, right? It seems that it would be very hard to tell about such a tiny thing as that.

 

[Bryan]

Here's a couple of Dr. Proctor's comments about that mysterious growth factor from alt.baldspot:

Newsgroups: alt.baldspot
From: [email protected] (Peter H. Proctor)
Date: 1998/03/09
Subject: Re: Why is it more difficult to grow frontal hair ?

The skin of your forehead produces hair-growth-inhibitory factors in a gradient centered about your eyes. BTW, this is why you get bitemporal recession, aka "widows peak". It is difficult to overcome both the balding process and this. So, the further bck you go, the better things work.

Peter H. Proctor, PhD, MD
http://www.drproctor.com

Newsgroups: alt.baldspot
From: [email protected] (Jason)
Date: 1998/03/10
Subject: Re: Why is it more difficult to grow frontal hair ?

Is a widows peak unrelated to male pattern baldness?


Peter H. Proctor
Mar 10 1998, 2:00 am

We do not really know. Most likely, it is a manifestation of the eye-centered production of hair-grwoth-inhibitory factors. BTW, one way we know about the "eye fields" is that occasionally newborns will exibit almost circular patterns of hair-grwoth-inhibition centered around their eyes. There are pictures in many embryology texts. It shos particularly well on new-borns because of their flat faces.

Dr. P

 

[mattj]

Eyebrows seem to be immune to this.

 

[jeffsss]

Eyebrows seem to be immune to this.

ever notice that your eyebrows have a little more meat under the hair than the rest of your head though?

I'm sure someone has thought of this before, but you may be on to something.

 

[michael barry]

Bryan,
Thanks for the excellent info.

Jeffsss....I pretty sure Ive read that eyebrows are not androgen dependent. You might search that and check me on it, but Im almost postiive Ive read that. I know some get eyebrow hair transplants in some places and minoxidil might help people with genetically thin eyebrows. One thing is for certain, eyebrows aesthetically are important to frame ones face. Ive seen a few folks in my life with little eybrow growth and it just takes so much away from their appearance.