How can caffeine grow hair when its a vasoconstrictor?

[hairwegoes]

Studies say it can promote hair growth but then minoxidial is opposite as its a vasolidator...also things like cayenne suggested for hair growth also vasolidators.

So what this mean? And how caffeine work topically?

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I just read the basis is something to do with it supplying energy to growth phase.

but are its vasoconstrictor properties damaging to hair growth?

 

[Contributed]

Don't think it does

 

[Seuxin]

Ha Ha,

Simple...the efficacity of minoxidil is absolutely NOT DUE to the vassodilatator effect.
Yes, minoxidil is a vassodilatator, BUT, the fact who minoxidil work for hair is NOT DUE to the vassodilatator effect.

That's all.

 

[hairwegoes]

Ha Ha,

Simple...the efficacity of minoxidil is absolutely NOT DUE to the vassodilatator effect.
Yes, minoxidil is a vassodilatator, BUT, the fact who minoxidil work for hair is NOT DUE to the vassodilatator effect.

That's all.

i see so whats its mechanisms? AND why do people suggest cayenne pepper and ACV for hair also? if not due to vasolidator propertites

 

[Giiizmo]

i see so whats its mechanisms?

As with many drugs, we don't know.

The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes. Hypothetically, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicle.

But it's a bit more complicated than that.

Minoxidil stimulated the transcriptional activity of pTopflash but not pFopflash. Nuclear accumulation of β-catenin was also observed after minoxidil treatment. Immunoblot further showed that minoxidil treatment increases the phosphorylation of GSK3β, PKA and PKB. Moreover, minoxidil induced Axin2, Lef-1, and EP2 expression. Source: http://www.ncbi.nlm.nih.gov/pubmed/21524889

 

[hairwegoes]

wow so they dont even know why it works lol, or they keep it to themselves?

are there any side effects to rogaine topically? any reason not to use it for a guy who notice his hair thinning and has money? 5% version best?

If only used once per day no effect? etc..Im trying to find reasons not to buy it