- Reaction score
- 642
Any recommendations?
Metformin?
https://www.ncbi.nlm.nih.gov/m/pubmed/20300828/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749730/
"AMP-activated protein kinase (AMPK) is recognized as a master regulator of energy homeostasis. In concert with the AMPK-kinase LKB1, it has been shown to provide a molecular link between obesity and postmenopausal breast cancer via its actions to inhibit aromatase expression, hence estrogen production, within the breast. The anti-diabetic drug metformin is known to increase the activity of AMPK and was therefore hypothesized to inhibit aromatase expression in primary human breast adipose stromal cells. Results demonstrate that metformin significantly decreases the forskolin/phorbol ester (FSK/PMA)-induced expression of aromatase at concentrations of 10 and 50 muM. Consistent with the hypothesized actions of metformin to increase AMPK activity, treatment with 50 muM metformin results in a significant increase in phosphorylation of AMPK at Thr172. Interestingly, metformin also causes a significant increase in LKB1 protein expression and promoter activity, thereby providing for the first time an additional mechanism by which metformin activates AMPK. Furthermore, metformin inhibits the nuclear translocation of CRTC2, a CREB-coactivator known to increase aromatase expression which is also a direct downstream target of AMPK"
How about indole 3 carbinol?
https://www.anabolicmen.com/dim-testosterone/
"There has been much discussion about DIM and its effects on the reproductive system. It’s claimed to work by reducing estrogen, while also promoting optimal free-testosterone levels via reduced SHBG (Sex Hormone Binding Globulin). "
http://nutrientjournal.com/indole-3-carbinol-inhibits-estrogen-metabolism/
"A study by Yuan et al. [6] concluded that indole-3-carbinol has anti-estrogenic activities which should prevent cancer in cervical cells (the second most common cancer in women). When 500 mg/day of indole-3-carbinol was administered to humans for 1 week by Jon J. Michnovicz and colleagues [5], a significantly increased (mean ± SEM) estradiol 2-hydroxylation was noted [29.3% ± 2.1% to 45.6% ± 2.1% (P<.001)]. Also, in rat osteoblasts, I3C abolished the E2-mediated stimulation of cell activities and increases the 2-hydroxylation of E1, resulting in formation of inactive and anti-estrogenic metabolites [11]."
http://www.superfoods-scientific-research.com/superfoods/indole-3-carbinol-benefits.html
"Indole-3-Carbinol (I3C) is a naturally occurring phytochemical found in cruciferous vegetables such as broccoli, cabbageand kale. Indole-3-carbinol is converted in the gut to diindolylmethane (DIM). Indole-3-Carbinol can help to maintain healthy hormonal balance for both men and women and therefore may support the health of the breast, prostate, and other reproductive organs.
[...]
Indole-3-Carbinol may prevent these by both reducing estrogen levels and blocking estrogen receptors. In a review published in the journal ‘In Vivo’ in 2008, DIM was recommended as a chemoprotective agent for both breast and prostate cancer. In addition, in a small double-blind trial, supplementation with 200 or 400 mg of indole-3-carbinol per day for 12 weeks reversed early-stage cervical cancer in 8 of 17 women.
Studies indicate that Indole-3-Carbinol has potential value as a chemopreventive agent for breast cancer through its estrogen receptor modulating effect. There is also evidence to support the fact that I3C has a different mechanism of action than tamoxifen and that these two substances can be used synergistically. Indole-3-Carbinol initiates a series of reactions in the body that culminates in the elimination of estrogen. Researchers have observed that metabolism of estrogen occurs via one of two pathways: The ‘harmful’ metabolic pathway, 16 alpha-hydroxylation, or the ‘beneficial’ metabolic pathway, 2-hydroxylation."
Metformin?
https://www.ncbi.nlm.nih.gov/m/pubmed/20300828/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749730/
"AMP-activated protein kinase (AMPK) is recognized as a master regulator of energy homeostasis. In concert with the AMPK-kinase LKB1, it has been shown to provide a molecular link between obesity and postmenopausal breast cancer via its actions to inhibit aromatase expression, hence estrogen production, within the breast. The anti-diabetic drug metformin is known to increase the activity of AMPK and was therefore hypothesized to inhibit aromatase expression in primary human breast adipose stromal cells. Results demonstrate that metformin significantly decreases the forskolin/phorbol ester (FSK/PMA)-induced expression of aromatase at concentrations of 10 and 50 muM. Consistent with the hypothesized actions of metformin to increase AMPK activity, treatment with 50 muM metformin results in a significant increase in phosphorylation of AMPK at Thr172. Interestingly, metformin also causes a significant increase in LKB1 protein expression and promoter activity, thereby providing for the first time an additional mechanism by which metformin activates AMPK. Furthermore, metformin inhibits the nuclear translocation of CRTC2, a CREB-coactivator known to increase aromatase expression which is also a direct downstream target of AMPK"
How about indole 3 carbinol?
https://www.anabolicmen.com/dim-testosterone/
"There has been much discussion about DIM and its effects on the reproductive system. It’s claimed to work by reducing estrogen, while also promoting optimal free-testosterone levels via reduced SHBG (Sex Hormone Binding Globulin). "
http://nutrientjournal.com/indole-3-carbinol-inhibits-estrogen-metabolism/
"A study by Yuan et al. [6] concluded that indole-3-carbinol has anti-estrogenic activities which should prevent cancer in cervical cells (the second most common cancer in women). When 500 mg/day of indole-3-carbinol was administered to humans for 1 week by Jon J. Michnovicz and colleagues [5], a significantly increased (mean ± SEM) estradiol 2-hydroxylation was noted [29.3% ± 2.1% to 45.6% ± 2.1% (P<.001)]. Also, in rat osteoblasts, I3C abolished the E2-mediated stimulation of cell activities and increases the 2-hydroxylation of E1, resulting in formation of inactive and anti-estrogenic metabolites [11]."
http://www.superfoods-scientific-research.com/superfoods/indole-3-carbinol-benefits.html
"Indole-3-Carbinol (I3C) is a naturally occurring phytochemical found in cruciferous vegetables such as broccoli, cabbageand kale. Indole-3-carbinol is converted in the gut to diindolylmethane (DIM). Indole-3-Carbinol can help to maintain healthy hormonal balance for both men and women and therefore may support the health of the breast, prostate, and other reproductive organs.
[...]
Indole-3-Carbinol may prevent these by both reducing estrogen levels and blocking estrogen receptors. In a review published in the journal ‘In Vivo’ in 2008, DIM was recommended as a chemoprotective agent for both breast and prostate cancer. In addition, in a small double-blind trial, supplementation with 200 or 400 mg of indole-3-carbinol per day for 12 weeks reversed early-stage cervical cancer in 8 of 17 women.
Studies indicate that Indole-3-Carbinol has potential value as a chemopreventive agent for breast cancer through its estrogen receptor modulating effect. There is also evidence to support the fact that I3C has a different mechanism of action than tamoxifen and that these two substances can be used synergistically. Indole-3-Carbinol initiates a series of reactions in the body that culminates in the elimination of estrogen. Researchers have observed that metabolism of estrogen occurs via one of two pathways: The ‘harmful’ metabolic pathway, 16 alpha-hydroxylation, or the ‘beneficial’ metabolic pathway, 2-hydroxylation."
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