Most of the problem from finasteride come from the increase in estrogen and the ratio between test:estro ratio
That's not what he's discussing.
A lot of the problems are definitely due to the effects of neurosteroids. For example,. it's now measured that people with PFS have no differences in their serum hormones, whereas they have significant differences in their cerebrospinal fluids.
It is also the case that people with PFS don't recover when taking treatments such as extra testosterone, clomid, etc. The one treatment that has helped people with mental slides is that of prolonged fasting, which is known to have a significant positive effect on the brain. You can go to any PFS help forum. Fasting helps them. Steroids do not help them. That refutes the position that it's due to testosterone and estrogen.
It may be that some of the sides that people report while taking finasteride (different from PFS) are due to testosterone and estrogen. However those sides have a simple solution -- stop taking finasteride. It's only the persistent sides that people need worry about.
I think people dive to deep into it, your hormones are directly effect, there really is no need to look further
"I think people dive to deep into it, your neurosteroids are directly effect, there really is no need to look further."
Come on man.
Deep down, most of this forum understands that inhibiting 5ar is a bad idea. That will be proven within a year or two, people will mostly drop finasteride for treatments such as Brotzu and CB0301 if they become available and are confirmed to be efficient.
I can't read the paper that
@Armando Jose posted. I'm at home and they want me to pay $39.95. No thank you.
As far as I know, we only know the dosage response curve of finasteride in the serum and in the scalp. That suggests that ~0.10 mg/day is the minimal effective dose, though it might be as high as 0.20 mg/day. Above that, the curve saturates. The person popping 1 mg/day doesn't keep more hair than the person popping 0.20 mg/day.
We have no idea what the response curve is in the brain, the liver, etc. If it flatters at a higher point, that suggests that going to ~0.20 mg/day would be beneficial, as you'd have every single benefit for hair, but none of the damage to the brain. However, we don't have measurements, and the anecdotes are few and far between as well as unreliable.
