Hsp60 Triggers Hair Cell Regeneration In Zebrafish

[Beowulf]

http://www.nature.com/articles/npjregenmed201613?WT.mc_id=FBK_NPG_1610_npjregmed

Abstract


After injury, zebrafish can restore many tissues that do not regenerate well in mammals, making it a useful vertebrate model for studying regenerative biology. We performed a systematic screen to identify genes essential for hair cell regeneration in zebrafish, and found that the heat shock protein Hspd1 (Hsp60) has a critical role in the regeneration of hair cells and amputated caudal fins. We showed HSP60-injected extracellularly promoted cell proliferation and regeneration in both hair cells and caudal fins. We showed that hspd1 mutant was deficient in leukocyte infiltration at the site of injury. Topical application of HSP60 in a diabetic mouse skin wound model dramatically accelerated wound healing compared with controls. Stimulation of human peripheral blood mononuclear cells with HSP60 triggered a specific induction of M2 phase CD163-positive monocytes. Our results demonstrate that the normally intracellular chaperonin HSP60 has an extracellular signalling function in injury inflammation and tissue regeneration, likely through promoting the M2 phase for macrophages.

 

[buckthorn]

^^ FOR ALL OF YOU THAT DON'T KNOW, THIS IS A f*****g ZEBRA FISH^^^ HALLE f*****g LUJAH !!!!!!!!!!!

 

[Beowulf]

at a quick glance it seems pretty promising considering that it has links back to 'special growth inflammation' and links to insulin resistance/ diabetes.

 

[Beowulf]

Faaaaaark

Someone should call Cortsarelis. The mutants with the HSP60 had the same reactions as the rats with diabetes. Then again diabetes only reduces the effectiveness of a particular biological function, mammals just can't regenerate hair cells. But then again what about dermarolling? Humans do seem to have some latent ability to regenerate hair cells, perhaps we simply need more HSP60 to regenerate all of our hair cells.

 

[InBeforeTheCure]

These are "hair cells" of the inner ear (important for balance and hearing), not hair follicles of the skin.

 

[Beowulf]

These are "hair cells" of the inner ear (important for balance and hearing), not hair follicles of the skin.

The nature of hair cells is pretty vague though right? Lots of the literature seems to refer to unidentified stem cells as hair cells.