paulie72785
Established Member
- Reaction score
- 9
Here it is:-
Does DHT inhibit IGF-1 and any other growth factors after it reaches and makes contact with the androgen receptors or is it before???
I mean if DHT does inhibit IGF-1 before reaching the androgen receptors then i guess we figured out why most androgen receptor agonist like RU58841 and CB0301 will not be performing to the desired efficiency
If we were able to lets say that all the androgen recpetors are blocked 100%(hypothetically) then it would mean we were able to help the further downfall of the follicle by not activating the specific gene expression but the DHT that is still present in the follicle and IGF-1 would still be inhibited with TGF-B1 and others and the hair follicle would just go down at the end but just very late
Then if the above i said is true, then we could help those who are prematurely balding by inhibiting the 5ar enzyme at the follicles and increasing IGF-1....
Im sure that i suck at proper sentence forming but i hope you all get the idea
Does DHT inhibit IGF-1 and any other growth factors after it reaches and makes contact with the androgen receptors or is it before???
I mean if DHT does inhibit IGF-1 before reaching the androgen receptors then i guess we figured out why most androgen receptor agonist like RU58841 and CB0301 will not be performing to the desired efficiency
If we were able to lets say that all the androgen recpetors are blocked 100%(hypothetically) then it would mean we were able to help the further downfall of the follicle by not activating the specific gene expression but the DHT that is still present in the follicle and IGF-1 would still be inhibited with TGF-B1 and others and the hair follicle would just go down at the end but just very late
Then if the above i said is true, then we could help those who are prematurely balding by inhibiting the 5ar enzyme at the follicles and increasing IGF-1....
Im sure that i suck at proper sentence forming but i hope you all get the idea