Immune modulation of hair follicle regeneration

[waynakyo]

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The mammalian hair follicle undergoes repeated bouts of regeneration orchestrated by a variety of hair follicle stem cells. The last decade has witnessed the emergence of the immune niche as a key regulator of stem cell behavior and hair follicle regeneration. Hair follicles chemotactically attract macrophages and T cells so that they are in range to regulate epithelial stem cell quiescence, proliferation and differentiation during physiologic and injured states. Disruption of this dynamic relationship leads to clinically significant forms of hair loss including scarring and non-scarring alopecias. In this review, we summarize key concepts behind immune-mediated hair regeneration, highlight gaps in the literature and discuss the therapeutic potential of exploiting this relationship for treating various immune-mediated alopecias.

Immune modulation of hair follicle regeneration - PubMed

The mammalian hair follicle undergoes repeated bouts of regeneration orchestrated by a variety of hair follicle stem cells. The last decade has witnessed the emergence of the immune niche as a key regulator of stem cell behavior and hair follicle regeneration. Hair follicles chemotactically...

pubmed.ncbi.nlm.nih.gov

 

[Armando Jose]

thank you for sharing this interesting review. In the text:
"Compelling evidence has emerged painting a complex relationship defined by mutual responsibility between HFs and immune cells during physiologic hair regeneration with T cells and macrophages as the predominant actors"
and
"Murine hair cycling occurs in regenerative waves characterized by dramatic architectural and mitotic changes across the entire skin"

This issue is more complex in human hair scalp due at its asynchronicjty in hair cycle.