Is post minoxidil syndrome(pms) real?

YoungBalder15

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He also used propecia before minoxidil.

But yes there are some signs minoxidil could have the same effects as finasteride. Still think this is much more rare than people with PFS.

Anyway, anything that disrupts your endocrine system can have long term hormonal effects like PFS, hypogonadism, PSSD, etc.
In one sense minoxidil is more risky because the way minoxidil works for hair loss is still unknown. There are some theories how minoxidil works on hair.

And there are many people who report pms even after they quit minoxidil.

Minoxidil and heart side effects. A person said minoxidil can change shape of your heart.
 

Lumalux

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As far as I know, Minoxidil does not have any affect on the user's hormonal profile (unlike Finasteride which works through hormonal pathways). Any ED effects should be from changes in blood pressure and should resolve soon after discontinuing the Minoxidil.
 

BurningCoals

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Like stated in that thread, he was on a LOT of minoxidil + many other endocrine disrupting sh*t.

His medications included minoxidil 50 mg daily, labetalol 400 mg daily, furosemide 320 mg daily, potassium 80 mEq daily, quinapril 20 mg daily, spironolactone 100 mg daily, simvastatin 40 mg daily, lansoprazole 30 mg daily, and aspirin 81 mg twice a week
Yeah that's true, the comment was more in a joking way, but still though it's messed up that that's a potential side effect (though I'm sure the other drugs contributed, or were possibly the cause themselves rather than the min).
 

YoungBalder15

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Yeah that's true, the comment was more in a joking way, but still though it's messed up that that's a potential side effect (though I'm sure the other drugs contributed, or were possibly the cause themselves rather than the min).
In one sense minoxidil is more risky because the way minoxidil works for hair loss is still unknown. There are some theories how minoxidil works on hair.

And there are many people who report pms even after they quit minoxidil.

Minoxidil and heart side effects. A person said minoxidil can change shape of your heart.
 

Hats

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Hey man, just wanted to say thanks for sharing your story and sorry to hear that you have suffered all that. I've been prescribed oral minoxidil and you have definitely given me reason to think twice. Wishing you a full and speedy recovery.
 

Johnson40

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Lmao tap water and oxygen consumption will give some people side effects.
I'm all for sharing your stories, personal experience and all, but sometime we just give too much credits to those.

Like always the same story, ED and depression ( Two completely uncommon conditions in hypocondriac, distressed or aging men ) appearing out of nowhere and god knows why completely impossible to explain by any metrics, no scan, no test show anything wrong.

Knowledge is just a source of stress nowadays, people can just can use google to find new fear and perpetual things to worry about.
 

JaneyElizabeth

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As real as one makes it.... I do note that this completes the circle of all meds that promote hair stability/regrowth are hormonal in nature which makes it easier for me to say that Baldness is always and everywhere a hormonal event.

I mean, I probably expected meds to be somewhat feminizing and I don't think there's much danger in using min/finasteride at normal amounts but again you pays your money and you takes your chances. Caucasian hair is almost always expressed more fully as either a juvenile or a female compared to adult males. This isn't true in other races and Siberians appear to have the exact same hair experience, male and female, even in terms of having oval shaped hair lines. People take shots at transgender folks but anyone who takes any med to improve hair outcomes is promoting androgyny in themself. As St. Paul claimed, hair is for women, not men and it's their glorious covering. Men should be happy with being men, perhaps and letting nature take it's course.

How about you, Will says Janey? I wouldn't change a thing, Jane as you look beautiful to me with all of that hair....
 
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sonofvegeta

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f*****g A ....everyday i read something new about minoxidil and finas.....f*** that brothers just save up your cash and get hair transplant , idk seems pretty reasonable to me ?
 

JaneyElizabeth

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f*****g A ....everyday i read something new about minoxidil and finas.....f*** that brothers just save up your cash and get hair transplant , idk seems pretty reasonable to me ?
We have been through ad nauseam while transplants only work for a small, select group of people but basically, people like Sting, although he hasn't, can get incredible results from transplants but most balding people cannot for several reasons but primarily transplants do not play well with Dupa/diffuse thinning which is a huge percentage of balding males. Things are better now but in the past, people routinely looked worse, if not much worse from transplants, even if done competently given the technology at the time. Some men just have the hairline done and that used to be impossible without the baby doll hair look which is much more rare now but it happens. I tend to see people who look like a young Richard Dreyfus and that's the general look unless someone has perfect, unaffected fringe hair that remains high all around and which also has something comparable to juvenile texture. Otherwise, you move scraggly hair from the back and sides elsewhere where it can fail, scar or at best, look like grass growing in the parking lot.

I had a horrible experience in the 80's, a better one with slight refinements in the 90's but I regret ever doing it since finasteride came out shortly after. Even in the 80's though, there were great results for a very select few and the key was to have full blown male pattern baldness and not diffuse thinning at all. It's the opposite of what you might think but it remains true. Dupa-type hair will fail eventually and I have posted pics of my scalp with hundreds of circular non-productive plugs, until microneedling saved my hair and cured my psychic scars.

There's a reason why this is hard my friend and facile solutions don't exist. There are costs and some times heavy costs to pay and not just in terms of money. Many guys literally cannot stand the fact that finasteride lowers DHT. You will never convince them that this is a negligible effect for 90 percent of us because they are fixated on the lower androgen part. Oh, and also, competent doctors require the use of finasteride and dutasteride not just for the patient but to avoid being sued because they know that transplants are not in fact, forever and just imagine your new transplant shrinking by the year while your dupa-depleted hair continues to lower in terms of being fringe hair. You end up looking bizarre and the baby doll look was also bizarre and I had to look away from a friend in law school every time because he was completely bald except for baby doll looking transplants in front that were pluggy and humiliating to me, for him. He later got refinements and it looked better but this fellow started balding in his teens and it was hopeless. His sister was beautiful so I assume he was once as a teen. Heartbreaking.

Best,
Janey
 
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sonofvegeta

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that was a lot to read ..i don't know i understood it or not and i am sober right now....basically I think you said those who cannot get hair transplant because too bald or bad hair then yes I get it, but those who are Norwood 1-3 maybe even 5 but have great donor hair and just need some small to medium work like hairline rebuilt or some on top and if money is not issue, all I am saying is go for it...other wise a life of pills /finas/minoxidil....i am a numbers guy....do the math....only a matter of time until those figures exceed a transplant....and we're not even talking about the side effects.
 

JaneyElizabeth

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We're not sure if minoxidil has no affect on the endocrine system though:

Minoxidil may suppress androgen receptor-related functions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039155/


Minoxidil Acts as an Antiandrogen: A Study of 5?-reductase Type 2 Gene Expression in a Human Keratinocyte Cell Line

Thanks for posting that study. I don't see it as negative at all. It is explicative of many things that are puzzling but male hair loss, if not female hair loss, is virtually always a hormonally-driven event and not caused by stress or diet or lack of sleep except in extremely rare cases. It doesn't matter if your father, brother and six uncles all have rock and roll hair. Bayesian analysis cuts through all of that and the mathematics are not difficult but basically any 18 year old who sees baldness, well I was 19, even with a father and a brother with great hair, has in essence seen his own hole card. This means that analyzing relatives only works before you notice hair loss. Dermatologists must not take statistics because they continue feeding, cynically for profit, this ridiculous canard about family relatives and whether it is predictive of future baldness. Of course it is and nobody denies that but it is only useful before seeing hair loss. Afterwards, it's a huge distraction for these young guys and they lose a year waiting for Telogen Effluvium to grow back and that's rare.

I never feed that sentiment when people ask "guess if I am going bald?" because if you say yes, half of them shoot back about their fathers, brothers and uncles and that their doctor says they only have Telogen Effluvium. Then why are you asking a bunch of guys on the internet? Sigh.

In rebuttal then, why would applying minoxidil help increase beard growth, which is seemingly dependent upon androgens and if minoxidil lessens androgens or receptor activity then what accounts for this? FtM's seem to do this regularly and one doctor, name of Will Powers touts minoxidil for beards. I think that it is loony but it points to what we still do not understand. In most mammals, DHT/T control hair growth, not estrogen. So there's something about intermixing patches of body that are generally without hair and those where hair regularly grows since unlike murcine species we are not fully covered in hair and seemingly have fewer follicles. I don't think anyone knows and that's why some guys will say DHT grows hair until their dying days and they are right, absolutely, but it doesn't grow scalp hair and we all know that empirically from looking around at other caucasians.
 
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JaneyElizabeth

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that was a lot to read ..i don't know i understood it or not and i am sober right now....basically I think you said those who cannot get hair transplant because too bald or bad hair then yes I get it, but those who are Norwood 1-3 maybe even 5 but have great donor hair and just need some small to medium work like hairline rebuilt or some on top and if money is not issue, all I am saying is go for it...other wise a life of pills /finas/minoxidil....i am a numbers guy....do the math....only a matter of time until those figures exceed a transplant....and we're not even talking about the side effects.
Janey processes and types faster than the cables can transmit so I get that and I wasn't being harsh at all. I got one and two if you consider the required refinements since I did have some plugginess and it never was like having my teen hair back. The scars hurt for years and they still itch somewhat although microneedling is shrinking them over the last 24 months. White males, many of us, are genetically programmed for beards and not scalp hair and we have no idea why. It's not true for pure blood Africans or Native Americans or the Inuit and formerly wasn't true for Asians. Baldness developed around the Mediterranean and we don't know why but probably not for Vitamin D reasons since it was sunny down there. It might be a mutation that means little to nothing but scalp hair is negatively correlated with having a heavy beard and heavy body hair. Other races scarcely have body hair at all. Nobody on here gets it that hair regrowth is nothing but a search for yes, youth, but as we age, it's a search for androgyny. I admit it and I think that I have always known this.

And yes, you understood fine from your answer. I hope you can find your solutions for you, my friend.
 

inmyhead

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I found funny comment on that video
I took a topical shampoo called regenepure dr which contains saw palmetto and ketoconazole that stuff destroyed me. It’s been 4 years since my crash and I relate to everything you are going through. I’ve tried TRT, hcg and prohormones and nothing works. Stay strong brother. I have a feeling are issue is androgen receptors related. There’s a hormone called trestolone, I have my hands on some and I plan on using it soon to see if this can fix the sexual sides.
 

BurningCoals

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I found funny comment on that video
I took a topical shampoo called regenepure dr which contains saw palmetto and ketoconazole that stuff destroyed me. It’s been 4 years since my crash and I relate to everything you are going through. I’ve tried TRT, hcg and prohormones and nothing works. Stay strong brother. I have a feeling are issue is androgen receptors related. There’s a hormone called trestolone, I have my hands on some and I plan on using it soon to see if this can fix the sexual sides.
Post Ketoconazole Syndrome Foundation
 

justinbieberscombover

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Everything that inhibits 5ar like saw palmetto can give PFS like symptoms. If you're sensitive to it, it could happen.
Doesn't minoxidil do the same thing? But I don't have sides from it.. at least yet

Maybe because it stays on the scalp for the most part
 
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