Melanin- the "Missing Link" to Why Blacks "Don't" Bald

OtyMac

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as much as caucasians..

Here is the study of comparison between skin color:

A cross-sectional study of male balding patterns in people of color​


Racial differences in AA patterns among White and Black men have been previously evaluated.1 Consistent with our results,
Black men were 4 times more likely than White men to exhibit ____no/minimal___ balding



Now the hypothesis of why that could be. Obviously, blacks have more melanin(note: not melatonin). In fact in every person literally I see grow back their hair there is a change from a pale white in their skin to a darker shade.

Melanin: a unifying theory of disease as exemplified by Parkinson’s, Alzheimer’s, and Lewy body dementia​



We propose the reason for the inverse relationship between melanin levels and ATP production is that melanin supplies energy to cells.(ME:avoiding possibly free radicals from the mitochondria providing it is highly damaged. Molecules/hormones that cause mitochondrial fission cause hair loss and those that increase mitchondrial fusion are hair growth candidates). If melanin provides energy to cells, then increasing melanin increases the amount of energy that cells are obtaining from melanin.

Therefore, it would follow that the body evolved in such a way that molecules that cause a great increase in melanin over an individual’s baseline, thus providing extra energy to the cell, would also limit mitochondrial ATP production, as this ATP would be wasted.

Due to its low stability in water, ATP cannot be stored in cells, except for very short periods of time (55).

Many studies have found that the use of light-emitting equipment leads to increased cellular ATP levels. It is not yet understood why this occurs (56). However, it is important to note that these studies measured cellular ATP levels, not cellular ATP production. We theorize that melanin is converting some of the emitted light into energy, and cells are able to utilize this energy instead of ATP. Thus, we theorize that there was not an increase in ATP production, as was assumed, and the reactions did not take place in the mitochondria. Instead, we suggest the measured increase in cellular ATP levels was due to a reduction in ATP usage due to an increase in energy produced by melanin, as a result of absorption of the light, which the cells were then able to utilize, conserving ATP (Figure 2A).

This also points to our conclusion that energy from melanin is the first choice of energy for a large number of cellular pathways and provides further explanation for the inverse relationship between melanin levels and levels of mitochondrial ATP production. As noted previously, ATP has low stability in water, and, therefore, can only be stored in cells for short periods of time (55). Thus, if energy from melanin is the first choice for many pathways, then if mitochondrial ATP production does not decrease much, there will be an overabundance of ATP in the cells, as seen in these studies.

Much of this ATP may end up degrading and, therefore, being wasted. This explains the evolutionary benefit to decreasing mitochondrial ATP production when there is an increase of melanin.
 

OtyMac

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Here is why us as Androgenetic Alopecia sufferers have too much mitochondrial fission because metabolic syndrome is associated to Androgenetic Alopecia.
Everybody is probably aware of elevated cortisol levels in Androgenetic Alopecia. Of course there are other things that cause fission also(dht, cytokines,etc.)



Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies​


For example, chronic exposure to elevated levels of cortisol or dexamethasone has been shown to increase mitochondrial fission and decrease fusion, which may lead to mitochondrial dysfunction
 

OtyMac

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Melanin, from an Evolutionary Remnant to the Myeloid Lineage Cell’s Main Energy Source.​

In fact, all cells require melanin to generate the energy they need to function and preserve form. Some cells contain melanin in greater quantity depending on their location and function (Figure 1).

Photoprotection and Skin Pigmentation: Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources​

 

Get my hair back

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After stumbling across some inspiring research a year ago, I started using melanin topically, for hair growth, using a mesomaroller for better penetration. I have to say it only affected my tan, I became very tanned despite the fact that it was winter and I was often asked where I flew on vacation) I used melanin for three months.
But unfortunately it had no effect on my hair growth.
 

Jakejr

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Maybe.. I dunno.. but Michael Jordan, Magic Johnson, Charles Barkley. George Foreman, Shaquille O’Neil would disagree
 

Modill

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Blacks go bald same as white people. Look at Tupac, bald with 20.
 

cloudsanrain

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Man
as much as caucasians..

Here is the study of comparison between skin color:

A cross-sectional study of male balding patterns in people of color​


Racial differences in AA patterns among White and Black men have been previously evaluated.1 Consistent with our results,
Black men were 4 times more likely than White men to exhibit ____no/minimal___ balding



Now the hypothesis of why that could be. Obviously, blacks have more melanin(note: not melatonin). In fact in every person literally I see grow back their hair there is a change from a pale white in their skin to a darker shade.

Melanin: a unifying theory of disease as exemplified by Parkinson’s, Alzheimer’s, and Lewy body dementia​



We propose the reason for the inverse relationship between melanin levels and ATP production is that melanin supplies energy to cells.(ME:avoiding possibly free radicals from the mitochondria providing it is highly damaged. Molecules/hormones that cause mitochondrial fission cause hair loss and those that increase mitchondrial fusion are hair growth candidates). If melanin provides energy to cells, then increasing melanin increases the amount of energy that cells are obtaining from melanin.

Therefore, it would follow that the body evolved in such a way that molecules that cause a great increase in melanin over an individual’s baseline, thus providing extra energy to the cell, would also limit mitochondrial ATP production, as this ATP would be wasted.

Due to its low stability in water, ATP cannot be stored in cells, except for very short periods of time (55).

Many studies have found that the use of light-emitting equipment leads to increased cellular ATP levels. It is not yet understood why this occurs (56). However, it is important to note that these studies measured cellular ATP levels, not cellular ATP production. We theorize that melanin is converting some of the emitted light into energy, and cells are able to utilize this energy instead of ATP. Thus, we theorize that there was not an increase in ATP production, as was assumed, and the reactions did not take place in the mitochondria. Instead, we suggest the measured increase in cellular ATP levels was due to a reduction in ATP usage due to an increase in energy produced by melanin, as a result of absorption of the light, which the cells were then able to utilize, conserving ATP (Figure 2A).

This also points to our conclusion that energy from melanin is the first choice of energy for a large number of cellular pathways and provides further explanation for the inverse relationship between melanin levels and levels of mitochondrial ATP production. As noted previously, ATP has low stability in water, and, therefore, can only be stored in cells for short periods of time (55). Thus, if energy from melanin is the first choice for many pathways, then if mitochondrial ATP production does not decrease much, there will be an overabundance of ATP in the cells, as seen in these studies.

Much of this ATP may end up degrading and, therefore, being wasted. This explains the evolutionary benefit to decreasing mitochondrial ATP production when there is an increase of melanin.
Mac I thing you need your eyes checked .
 
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