I have decided to give topical spironolactone a chance but I am already using minoxidil 2 times a day. I work all day and when I get home I use the minoxidil and go to sleep an hour after that or so. When can I put on the spironolactone? There is no way I can do it at work. So is it ok if I use it like an hour after minoxidil? I am just worried because people say you are supposed to leave the minoxidil and not touch your hair/scalp, so wouldn't the spironolactone counteract the minoxidil somehow? Do they cancel each other out in anyway when used together? Please help.
Minoxidil first, then spironolactone
- Thread starter He-Bat
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OverMachoGrande
Senior Member
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They do. I do the same. First I apply spironolactone, wait an hour and then apply my minoxidil.
HairlossSucks: For someone using Minoxidil and spironolactone, how would they avoid the smell?
Dr. Lee: Well they can be applied, essentially, one right after the other, fairly close together in time. It takes several hours for Spironolactone to react with Minoxidil, so by that time, it will already have been absorbed.
source: http://www.hairlosssucks.com/newsletter ... icle08.htm
Dr. Lee: Well they can be applied, essentially, one right after the other, fairly close together in time. It takes several hours for Spironolactone to react with Minoxidil, so by that time, it will already have been absorbed.
source: http://www.hairlosssucks.com/newsletter ... icle08.htm
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He-Bat said:
The term "DHT inhibitor" is just a bastardized expression that was made-up on hairloss sites like this one. I recommend that you use the same terminology used by doctors and scientists: in the context of fighting male pattern baldness, spironolactone is an "androgen receptor blocker", or simply "antiandrogen".
I think overall, it's probably a fairly mediocre topical antiandrogen.
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He-Bat said:So you belive it can make a difference though. People here seem to value your opinion.
Yes. If animal experiments mean anything, topical spironolactone certainly isn't as effective as, say, topical RU58841. But it's better than nothing at all.
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I feel like I should expand a tad on what I said before. Part of the problem is that topical antiandrogens in general simply aren't as effective on human balding scalp as they are on (say) balding stumptailed macaque scalp. Those furry little animals simply have a greater innate propensity for scalp regrowth than humans! There were lots of people a few years ago who were simply convinced that if they used topical RU58841, their hair would grow back, just like it does on the monkeys. Sadly, that isn't the case.
So there are two separate issues at work here: (1) topical spironolactone isn't as good as topical RU58841; and (2) even if it were as good, it still wouldn't work as well in humans as it does in the monkeys.
So there are two separate issues at work here: (1) topical spironolactone isn't as good as topical RU58841; and (2) even if it were as good, it still wouldn't work as well in humans as it does in the monkeys.
Bryan. Dr. Lee told me that spironolactone is very effective, and so is xandrox. Is he just saying that because he sells the stuff? The xandrox reviews I've read are pretty impressive though. But spironolactone and xandrox are expensive and time consuming so I don't want to waste time and money on something that doesn't even work. I did try revivogen for a year and that was totally useless. I am having a hair transplant next year, I am a nw3 and NOT taking finasteride, but I need to slow down my hairloss though, not expecting major regrowth, or any. What's your advice?
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He-Bat said:
Yes, I believe that's why he said that: he's selling the stuff. I think that's especially true of Xandrox! There is no scientific proof at all that azelaic acid works as a topical 5a-reductase inhibitor.
He-Bat said:
Xandrox also contains minoxidil, of course, so I think it works only to the extent that any topical minoxidil product works.
He-Bat said:
I certainly wouldn't waste money on Xandrox, which is basically just expensive Rogaine. I like Dr. Proctor's products, but they're expensive, too, especially the prescription Proxiphen. You might consider using the cheaper and OTC version of Proxiphen called "Prox-N", which maintained my own hair for the two full years that I used it exclusively.
rcom440
Senior Member
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Bryan said:He-Bat said:
That's up to you. Topical spironolactone works, although it's not as effective an antiandrogen as, say, RU58841. spironolactone is a lot cheaper and easier to obtain, though!
I think spironolactone is quite effective in combination with other products.
Recently Dr. Pickart claims that Copper Peptides is very effective antiandrogens but when he was asked by one of the people in his forum which one is better finasteride or Copper Peptides (Folligen in that case), he said:
"Folligen is certainly more natural than Propecia but I have no idea what works better." :woot: