New Research Published By Tsuji & Crew

[That Guy]

Credit to Paul Phoenix from the hairlosscure blog which lead me to this.

Lately, Tsuji and his team have published a number of new papers

The most relevant probably being "Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells"

Here's the abstract:

"Hair follicles develop from the ectoderm in embryos and cyclically regenerate using proper spatiotemporal signaling molecules, which are conserved in organogenesis during adulthood. Previously, we demonstrated that bioengineered hair follicle germs could regenerate functional hair follicles via a three-dimensional cell manipulation technique, which we named the "organ germ method ." We could also regulate the type of hair follicle and pigmentation with correct structures by rearranging the source of the cells. In this article, we describe a detailed protocol for the regeneration of functional hair follicles and their stem cell niches by the rearrangement of embryonic or adult hair follicle-derived epithelial and mesenchymal cells."

 

[hellouser]

we describe a detailed protocol for the regeneration of functional hair follicles and their stem cell niches by the rearrangement of embryonic or adult hair follicle-derived epithelial and mesenchymal cells."

Wasn't that their final hurdle in solving it for good?

 

[resu]

Reading that sounds like science-fiction, no way we'll see it in practice use in our lifetimes.

 

[That Guy]

Reading that sounds like science-fiction, no way we'll see it in practice use in our lifetimes.

Yeah, that's what I said about Bionic Limbs where the user has control over the fingers like something straight outta Star Wars ten years ago.

Guess what?

 

[Stupidon]

Wasn't that their final hurdle in solving it for good?

Does some have access to the paper and could answer to hellouser?

Maybe @Swoop ?

 

[paleocapa89]

Someone pls help me out here. Do they intend to create hair follicle germs that when transplanted turn into real follicles, or the germs are supposed to revive your own dying hair follicles. In other words would this help a burn victim as well, if he had no follicles in his scalp due to his injury or not?

 

[That Guy]

Someone pls help me out here. Do they intend to create hair follicle germs that when transplanted turn into real follicles, or the germs are supposed to revive your own dying hair follicles. In other words would this help a burn victim as well, if he had no follicles in his scalp due to his injury or not?

The hair follicle germs turn into hair follicles. They are recreations (using your own cells) of how follicles develop before you are born.

 

[paleocapa89]

I'm just a bit worried, that Tsuji is a brilliant researcher, but not a business man. They are obviously making progress and broadening the common knowledge of mankind, they are issuing papers and so on. But sometimes that is all researchers want to do. On the other hand (regardless how effective their treatment is) you don't see Replicel/Shiseideo publishing papers, they have a clear goal of going to market. The commercialization of a treatment/cure is a whole different story that requires different skills and mindset. Like how Steve Wozniak was a brilliant engineer but Jobs was the one who pushed the product to the market. Anyway, fingers crossed.

 

[buckthorn]

I'm just a bit worried, that Tsuji is a brilliant researcher, but not a business man. They are obviously making progress and broadening the common knowledge of mankind, they are issuing papers and so on. But sometimes that is all researchers want to do. On the other hand (regardless how effective their treatment is) you don't see Replicel/Shiseideo publishing papers, they have a clear goal of going to market. The commercialization of a treatment/cure is a whole different story that requires different skills and mindset. Like how Steve Wozniak was a brilliant engineer but Jobs was the one who pushed the product to the market. Anyway, fingers crossed.

when someone holds in their hand a technology that could potentially make billions, you'd be surprised at how quickly they become a business man.

 

[paleocapa89]

I'm not sure who owns the IP for example. To me it seems like they are working on a bunch of stuff (hair, teeth, glands etc) all in the topic of organ germ regeneration. This is huge, don't get me wrong. It can potentially pave the way to artificial organ creation and much more in the future. But they don't seem to have clear aim at fixing baldness which would focus their research, efforts, and activities around one target.

Anyway, I don't now why I am such a downer, I guess I'm in a bad mood today.

 

[That Guy]

I'm not sure if you heard but three companies have teamed up to commercialize the treatment with trials beginning next year.

RIKEN (where Tsuji made this discovery), Organ Tech and a Japanese electronics company called Kyocera are each doing their part to bring the treatment to market. Tsuji has probably no involvement beyond the science.