Nizoral 1% Twice A Week Seems, Rinses Immediately, To Work For Mild male pattern baldness

[ajbrah]

I experienced pretty obvious signs of male pattern baldness from 18-20, particularly in the widow's peak and some thinness on the sides. It's been 3 years since starting Nizoral 1%, starting at the age of 20, and the thinning seems to have stopped and perhaps even reversed somewhat. My sides are thick and no scalp shows through anymore, despite having blond hair, even with a buzz cut. My hair has really never looked better.

I apply it every Monday and Thursday and rinse it out immediately, because of the fact that it stays in the endothelium at high concentrations for around 7 days and has a high protein binding affinity.

Anyone else had success with Nizoral 1%? Based on its mechanisms, theoretically it should work better than spironolactone. Is it placebo?

 

[ajbrah]

Finasteride gives me horrific sides, and minoxidil has sides I would never want so I've avoided it. spironolactone is poorly reviewed. Thus, it seems ketoconazole is the best option.

 

[resu]

The cream maybe, the shampoo no, at best it just cleans the scalp and reduces inflammation.

 

[Roberto_72]

Anyone else had success with Nizoral 1%? Based on its mechanisms, theoretically it should work better than Spironolactone. Is it placebo?

I think you know something we don't

 

[ajbrah]

The cream maybe, the shampoo no, at best it just cleans the scalp and reduces inflammation.

Any scientific info to back this up?

 

[Afro_Vacancy]

The shampoo gives very modest benefits for androgenic alopecia. Best case scenario is that it slows down hair loss and reduces itches (still something).

And you have to leave it on for several minutes.

 

[ajbrah]

The shampoo gives very modest benefits for androgenic alopecia. Best case scenario is that it slows down hair loss and reduces itches (still something).

And you have to leave it on for several minutes.

Why do I have to leave it on for that long? What is this based on, aside from ketoconazole shampoos like Regenepure recommending you leave it in for 5 minutes? When I used to leave it in, it didn't seem to make a difference aside from negative effects. Plus the detergents are too harsh on the scalp, and I worry about any amount of bloodstream penetration since it is highly estrogenic. No studies have been done on whether topical administration to the scalp can cause elevated estrogens or depleted androgens, but that is something I would also assume would be a greater risk when you leave it in.

If you can give me some hard reasoning for leaving it in, I would appreciate it.

 

[whatevr]

Ketoconazole's AR-binding capacity is not worth mentioning as a topical. The reason we use it for Androgenetic Alopecia is its capability to inhibit 17α-hydroxylase and 17,20-lyase, thereby preventing conversion of pregnenolone and progesterone into harmful androgens. This also means it is good in combo with oral pregnenolone or topical progesterone as they can be used for their anti-androgen effect without turning into androgens themselves. In theory.

 

[Esprit]

Interesting theory, not sure how true it can be. I use Regenepure DR, which is supposedly 1%? I've lost so much hair from using this it's ridiculous. 3 months 3 x times a week, left in for a few minutes, and my hair is worryingly much sparser than it was at Xmas. So, I'm sceptical. I don't wash my hair more than 3 times a week.

 

[Afro_Vacancy]

What we know is that nizoral has modestly positive results in clinical trials.

 

[rclark]

Prescription Nizerol (2%) shows some potential. This guy probably doesn't have aggressive baldness, which
is fortunate for him.

 

[kj6723]

it should work better than Spironolactone

 

[resu]

What we know is that nizoral has modestly positive results in clinical trials.

Studies paid and made by the makers themselves.

 

[Afro_Vacancy]

Studies paid and made by the makers themselves.

Did you verify that?

 

[resu]

Did you verify that?

Yes, a search may give you results.

 

[whatevr]

And to paraphrase the OP with my own experience.

Ketoconazole 2%, 3x a week, left on for 30 minutes, doesn't do sh*t for male pattern baldness.

 

[rclark]

Even the 2% prescribed amount is under study. There's really nothing proven, either way.

It can't HURT, but that doesn't mean it will help either.

 

[ajbrah]

It would still have to be capable of penetrating the skin which it does not with these shampoos.

I would still like to know why people say ketoconazole does not have the opportunity to penetrate the scalp when rinsed out quickly, especially when thoroughly rubbed in. I've always felt that my hair received pretty much the same thickening, anti-shedding, anti-itching effect when rinsed immediately as opposed to left to soak.

I have been using my shampoo mixed with powdered finasteride and other things. One pump of this shampoo has about 0.185mg finasteride, and I rinse it out immediately. I still get the same head rush I used to get with oral finasteride, which tells me that, at the very least, it is penetrating the scalp and some of it is entering my bloodstream.

The scalp is a thin layer of skin densely populated by capillaries and pores. It is one of the areas where medications can enter the bloodstream rather quickly. Since I can feel the finasteride head rush just a minute or so after I've rinsed out the shampoo, I don't see why ketoconazole couldn't penetrate the scalp tissue at the very least.

 

[ajbrah]

Systemic Adverse Effects
Although hepatotoxicity, decreased testosterone concentrations, and decreased ACTH-induced corticosteroid concentrations have been reported with oral ketoconazole,32 105 110 these adverse effects have not been reported with topical ketoconazole105 110 and are unlikely since the drug does not appear to be appreciably absorbed following topical application to skin.

I know it's not absorbed into the bloodstream in large quantities, but does this really mean it can't have an effect on the hair follicles, which are basically right at the surface of the skin and are so open to the elements that they are susceptible to dirt, bacteria, and oils? Plus ketoconazole has a high protein binding affinity, particularly to keratin and the stratum corneum, which are major components of the scalp.

Perhaps the reason why topical ketoconazole does not enter the bloodstream very well is because it's so readily absorbed by the skin itself.

 

[Esprit]

I would still like to know why people say ketoconazole does not have the opportunity to penetrate the scalp when rinsed out quickly, especially when thoroughly rubbed in. I've always felt that my hair received pretty much the same thickening, anti-shedding, anti-itching effect when rinsed immediately as opposed to left to soak.

I have been using my shampoo mixed with powdered finasteride and other things. One pump of this shampoo has about 0.185mg finasteride, and I rinse it out immediately. I still get the same head rush I used to get with oral finasteride, which tells me that, at the very least, it is penetrating the scalp and some of it is entering my bloodstream.

The scalp is a thin layer of skin densely populated by capillaries and pores. It is one of the areas where medications can enter the bloodstream rather quickly. Since I can feel the finasteride head rush just a minute or so after I've rinsed out the shampoo, I don't see why ketoconazole couldn't penetrate the scalp tissue at the very least.

What is the powdered Finasteride, and how does that work, any sides, and easy to get, or are we just talking crushed pills?