Oxidative stress impedes wnt-signalling in ageing, bone loss

[michael barry]

http://www.jbc.org/cgi/reprint/282/37/27298.pdf



The older you get, the less wnt signalling you have. ROS causes it in a roundabout way. This probably happens in hair also. The article is concerned with bone and osteoporosis issues. The pathways are familiar here: beta catenin, wnt, etc. Its a very interesting article that Peter Proctor was kind enough to send to me. The damage really does look like its mediated by t-cells. If we could find out what was downstream of androgen uptake that "causes" it, we'd have it all figured out. Perhaps its a perfect mixture of things (the expression of TGF-beta, the pgd2 receptor being simultaneously activated, with DKK-1, and PKC all "clicking" at once, gets the T-Cells' attention in a "perfect storm" of just the right chemical signalling environment to be taken as a "foreign body"? Who knows, but perhaps it isn't just *one* thing, but a mixture of chemical signals in a particular follicle?

Just sayin'

 

[purecontrol]

Just to point out body pH is highly depedant on calcium leaching "osteoporosis".

It has been known for a long time that low pH and high insulin (poor glucose response) are what cause inflamation.

Thing that help increase pH: Magnesium (tarate or glycinate), Calcium (only citrate), Potassium (only citrate), chlorophyll (from any green super foods), Germanium (only injectable with proper pH)

Next would be to drink water with a high pH and no chlorine, avoiding all processed food, and making diet based on high pH foods, ie lemons, limes, etc

 

[michael barry]

The article I posted, entitled "Oxidative Stress Antagonizes WNT-Signalling in Oseoblast Precursers by Diverting B-Catenin to T-cell Factor from Forkhead Box-O Mediated Transcription"
...................has NOTHINGto do with diet at ALL.


The experiments described were with cells outside the body cultivated in labs where samples were taken for chemical analysis to see what is going on. Nothing "in vivo" about this. To try and hoist this up on the petard of acidic or base Ph diets is DISHONEST and MISLEADING, whatever the benefits of a more natural diet may be.

The researchers sure as hell wouldn't approve. The basic thing one gets out of the article is this: as WNT signalling decreases, more ageing happens via the inflammatory route in some bone cells. They mention nothing of diet.

 

[purecontrol]

So then how do you plan on using this information to help with your hair problem? Answer there as information means notning with out and ends that you can actually benefit from. How do you aply this information to real world aplication and how is it even relevant?

concerned with bone and osteoporosis issues

I explained what primarily causes bone loss, which also happens to cause inflamation. Whether you like it or not your body is effected by your enviroment weather it be physcial or mental.

Inflamation is caused by excessive oxidation and then causes more oxidation and more inflamation, ala the runaway inflamation.

How does this happen? Your enviroment both physical and mental effects.

So if you can either A)stop or B)slow down osteoporosis you will infact lower the inflamation and other negative effects. So how do you do this? By keeping the body in a proper homeostatic state which is what it is attempting to achieve in the firts place. This is the same reason you have high DHT and Estrogen levels ect.

It is not just magically happening for no reason LOL

Let me ask you this do you even understand why osteoporosis happens, why does your body leach calcium from the bones in the first place. Why would your body do something that seems so detrimental?

Oh and one last little note for you, at what time through out the day does the body produce the most oxidants and why?


Oxidation is liked to aging, which has been known for a very long time.

 

[docj077]

I explained what primarily causes bone loss, which also happens to cause inflamation. Whether you like it or not your body is effected by your enviroment weather it be physcial or mental.

Inflamation is caused by excessive oxidation and then causes more oxidation and more inflamation, ala the runaway inflamation.

I think that you're very confused about human physiology. I counted over 40 causes for osteopenia and osteoporosis and not one of them said anything about ROS.

80% of bone mass in any given individual is genetic with your osteoporotic risk being closely related with abnormalities in the estrogen and vitamin D receptors.

I looked on MDconsult and there was not one single mention of acid/base imbalances causing bone lose and what is even more important is that there is no recommendation for running ABGs to look for a metabolic disturbance. In fact, I have to question whether or not you even know what a human being looks like that is suffering from chronic acid/base disorders. You pretty much need to have a chronic illness like chronic obstructive pulmonary disease to force your body into being unbalanced. The human body always hangs out around 7.35-7.45. It never overcompensates, so I really don't understand where you're coming from as human beings don't just BECOME acidotic or alkalotic...and stay there... without an underlying severe disease process.

Of equal importance is that I can find no recommendation from any medical society anywhere that improving acid/base balance improves osteoporosis outcomes or that the lifestyle modifications that you mention make any difference whatsoever. I can only find literature in which researchers have used FDA approved medications that target specific bone formation/destruction and calcium uptake/reuptake pathways and by targeting these pathways up to 70% of patients respond to treatment.

 

[tino]

Citation:80% of bone mass in any given individual is genetic with your osteoporotic risk being closely related with abnormalities in the estrogen and vitamin D receptors.


-----------------


Defect or abnormal estrogen-receptor density(impaired estrogen signaling) causes a prooxidative imbalance.Estrogen is one of the most potent antioxidants in our system,it modulates for example Glutathione peroxidase and superoxid dismutase.


citation:I counted over 40 causes for osteopenia and osteoporosis and not one of them said anything about ROS.
--------------------------------------------





http://www.ncbi.nlm.nih.gov/pubmed/1788 ... d_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/1758 ... d_RVDocSum


http://www.pubmedcentral.nih.gov/articl ... d=16670759


Tino

 

[docj077]

Citation:80% of bone mass in any given individual is genetic with your osteoporotic risk being closely related with abnormalities in the estrogen and vitamin D receptors.


-----------------


Defect or abnormal estrogen-receptor density(impaired estrogen signaling) causes a prooxidative imbalance.Estrogen is one of the most potent antioxidants in our system,it modulates for example Glutathione peroxidase and superoxid dismutase.


citation:I counted over 40 causes for osteopenia and osteoporosis and not one of them said anything about ROS.
--------------------------------------------





http://www.ncbi.nlm.nih.gov/pubmed/1788 ... d_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/1758 ... d_RVDocSum


http://www.pubmedcentral.nih.gov/articl ... d=16670759


Tino

And, do you have the results of a large randomized trial that demonstrates that anti-oxidant administration alone reduces or even reverses osteoporosis or are you (like the other guy) going to continue to post studies that have no basis in medicine or this discussion whatsoever?

Unfortunately, even the very studies that you posted mentioned that their studies are either hypotheses or they are based on animal models, and thus, weakened by their own research methods. Time and time again, animal models have been used as a means to understand human physiology. However, you can not use animal models when it comes to hormone related problems or even for problem related to ROS. Human beings simply are designed differently which is quite evident by their lifespans and their ability to seemingly recover from oxidative stresses.

 

[tino]

Citation:And, do you have the results of a large randomized trial that demonstrates that anti-oxidant administration alone reduces or even reverses osteoporosis or are you (like the other guy) going to continue to post studies that have no basis in medicine or this discussion whatsoever?

Unfortunately, even the very studies that you posted mentioned that their studies are either hypotheses or they are based on animal models, and thus, weakened by their own research methods. Time and time again, animal models have been used as a means to understand human physiology. However, you can not use animal models when it comes to hormone related problems or even for problem related to ROS. Human beings simply are designed differently which is quite evident by their lifespans and their ability to seemingly recover from oxidative stresses.

----------------


If somone is scientific employed with Hormones and Redox Signaling, intrinsic and environmental Triggers,for him things are obvious.Animal Studys are just something that brings a little more light in the Truth.Conservative Medical practice ist far far away from doing the most and best for preventing degenerative disorders.The Question is,if somone has strong interst to make large randomized Trials with Antioxidants for bone loss?I think that Antioxidants alone,wont bring satisfactorily results in the line of primary prevention.They must given additive to other medications-for example Estrogen in the line of primary prevention..And also additive to calcium and Vitamin D....both interacts with IGF-1 and redox System.
For secondary Prevention they may slow the Progession when given alone or together with minerals.

Signs of Aging are nothing for normal health care providers.The Right adress is a versed anti-aging Doctor.It must be seen as a whole,and not just as a calcium or Estrogen/Androgen deficient disorder.The point of view must include hormonal, genetics,intrinsic/nutritive and environmental factors.Every aging promotional factor induces a disturbed redox balance,as a part of his degerative causale.

Tino

 

[tino]

Re: acid base imbalances

I looked on MDconsult and there was not one single mention of acid/base imbalances causing bone lose and what is even more important is that there is no recommendation for running ABGs to look for a metabolic disturbance. In fact, I have to question whether or not you even know what a human being looks like that is suffering from chronic acid/base disorders. You pretty much need to have a chronic illness like chronic obstructive pulmonary disease to force your body into being unbalanced.


------------------


A acid/base disturbance wich is untreadet over a long time,can lead to a chronic metabilic acidosis.And this can trigger or cause osteoporosis and more.I t lowers IGF-1 for example.


I have something from a Physicans Journal in german,and some more in English.


Chronisch metabolische Azidose: Prophylaxe entscheidend

Eine chronische metabolische Azidose ist therapiebedürftig, ebenso wie die zugrundeliegende Grunderkrankung. Azidosen treten als Folge von Nierenfunktionsstörungen, Osteoporose, Neoblase oder medikamenten-induziert (Cortison) auf und schädigen durch die proteinkatabole Stoffwechsellage den Knochenstoffwechsel, die Blutbildung und das Herz-Kreislaufsystem. Um der Übersäuerung des Organismus entgegenzuwirken, ist die Applikation von Natriumhydrogencarbonat in Form von magensaftresistenten Tabletten wesentlicher Bestandteil der Therapie. Mit diesem Thema befasst haben sich auch Experten verschiedenster Fachrichtungen (Beuth J, Friedrich T, Giebel W, Hänsel W, Kult J, Linß G, Sautter T, Schulz J, Weisser B).



Im Knochensystem kommt es bei einer chronischen metabolischen Azidose zur kompensatorischen Herauslösung von Kalziumkarbonat aus dem Knochen. Jede chronische metabolische Azidose geht so mit einem Verlust von Knochenmasse einher. Wenn im Alter die Funktionsbreite gesunder Nieren abnimmt, dann ist die natürliche Kompensationsmöglichkeit für einen starken Anfall von sauren Valenzen vermindert. Bleibt eine chronisch metabolische Azidose bei ausgeprägter Osteoporose unausgeglichen, geht der Knochenabbauprozess trotz eingeleiteter Osteoporosetherapie weiter. Zweck ist die Erhaltung einer optimalen Organfunktion. Mit basenbetonter Ernährung und einer Substitution an Bikarbonat lassen sich im Alter Nieren, Knochen und Muskulatur schützen und der Ausprägung einer metabolischen Azidose entgegenwirken.

Die Galenik bikarbonathaltiger Präparate ist von zentraler Bedeutung, weil HCO3- mit der Magensalzsäure HCl zu Kohlendioxid (CO2) und Wasser (H2O) reagiert. Dabei kommt es nicht nur zu unerwünschtem Verbrauch von Wirkstoff, sondern vor allem zur Reizung der Magenschleimhäute. Fälle von Magenrupturen nach Einnahme von nicht magensaftresistentem Bikarbonat sind beschrieben. Entscheidend für eine sichere und verträgliche Therapie ist die Verwendung von magensaftresistentem Bikarbonat. Mit den nachfolgenden Thesen soll, so die Expertenkommission, ein größeres Bewusstsein für die Bedeutsamkeit einer Azidosetherapie im Zusammenhang mit anderen chronischen Folge- oder Grunderkrankungen geschaffen werden:

Störungen des Säure-Basen-Haushaltes können langfristig zu einer chronischen metabolischen Azidose führen. Hiermit verbunden ist ein erhöhter Abbau an Knochenmasse, Muskelmasse und eine Verschlechterung der Funktion der Nieren. Eine rationale Differentialdiagnostik bei Störungen des Säure-Basen-Haushaltes ist durch die Bestimmung von pH-Wert, pCO2 und der Bicarbonatkonzentration im Blut möglich. Messungen des Urin-pH-Wertes können als Tagesprofil einen Anhaltspunkt für das Vorliegen einer metabolischen Azidose liefern. Das wichtigste Puffersystem des Organismus ist das Kohlensäure-Bikarbonat-Puffersystem, das etwa 70% der Gesamtpufferkapazität des Blutes ausmacht.

Eine dauerhafte Übersäuerung mobilisiert Calcium als Ersatzpuffer aus den Knochen und kann daher zu einer Osteoporose führen. Im Alter nimmt die Fähigkeit der Nieren ab, das Säure-Basen-Gleichgewicht effizient zu regeln. Damit steigt die Gefahr, dass eine säurelastige Ernährung zu einer chronischen Azidose führt. Klinisch ist eine chronische metabolische Azidose schwer zu erkennen, typische Symptome fehlen häufig.

Bei Nierenfunktionsstörungen und Diabetes mellitus sind basenreiche Ernährung oder Basen-Substitution von Vorteil, da bei diesen Erkrankungen die Säureausscheidungskapazität eingeschränkt ist.

Bei einer chronischen metabolischen Azidose kommt es zu einem Mangel an Bikarbonat im Blut. Mit Hilfe von Bikarbonat-haltigen magensaftresistenten Basentherapeutika wie z. B. bicaNorm® lässt sich ein Defizit an der physiologischen Pufferbase Bikarbonat (= Hydrogencarbonat) ausgleichen. Als sehr häufige Nebenwirkungen von Bikarbonaten und Zitraten sind gastrointestinale Störungen auch schwereren Ausmaßes beschrieben, weil durch eine Alkalisierung des Magensaftes die Funktionen des Magens nachhaltig gestört werden.

Bikarbonat ohne magensaftresistenten Überzug wird im Magen weitgehend zu Kohlendioxid und Kochsalz zersetzt. Die Verdauungsfunktion des Magensaftes und die antibakterielle Wirkung der Magensäure werden dadurch abgeschwächt. Da bei bicaNorm® das Bikarbonat den Magen unbeschadet passiert und erst im oberen Dünndarm freigesetzt wird, bleiben die Funktionen des Magens voll erhalten. Durch bicaNorm® wird das Dünndarmmilieu alkalisiert, was die Verdauungsenzyme des exokrinen Pankreas optimal aktiviert. Der Wirkstoff Bikarbonat wird danach nahezu vollständig resorbiert. Durch die magensaftresistente Galenik von bicaNorm® wird die Vitamin-B12-Kopplung im Magen an den Intrinsic Factor sowie die Resorption im Dünndarm nicht gestört. Bei geriatrischen Patienten mit chronisch metabolischer Azidose z.B. bei Niereninsuffizienz ist bicaNorm® angezeigt, um den negativen Folgen der Azidose auf verschiedene Organsysteme vorzubeugen.








Abb. 1: Die glomeruläre Filtrationsrate nimmt mit zunehmendem Alter ab (modifiziert nach Nephron 17:270-278).



Zur Verordnungs- und Erstattungsfähigkeit

bicaNorm® kann bei den Indikationen Neoblase und bei eingeschränkter Nierenfunktion zu Lasten der gesetzlichen Krankenkassen verordnet werden (Azidosetherapeutika gemäß AMR 16.4.4).








Abb.2: Magensaftresistente Galenik von bicaNorm® garantiert Anwendungssicherheit und Wirksamkeit bei der Therapie der chronischen metabolischen Azidose.


Fazit

Die Behandlung einer chronisch metabolischen Azidose ist von entscheidender Bedeutung, um Folgeerkrankungen wie Osteoporose, Muskel-atrophie, Verdauungsstörungen und Niereninsuffizienz zu vermeiden. Insbesondere bei geriatrischen Patienten, die ohnehin häufig unter einer reduzierten Nierenleistung leiden, kann daher Bikarbonat substituiert werden. Dabei sind magensaftresistente Formulierungen wie bicaNorm® besonders wirksam, verträglich, sicher und können langfristig ohne gastrointestinale Nebenwirkungen appliziert werden.

Expertenkommission:

Prof. Dr. J. Beuth, Leiter des Institutes zur wissenschaftlichen Evaluation naturheilkundlicher Verfahren,Universität Köln

Dr. T. Friedrich, Geschäftsführer des Apothekerverbandes in Schleswig-Holstein, Kiel

Prof. Dr. W. Giebel, Facharzt für Urologie, Chefarzt der Urologischen Abt. Gisunt Klinik Zetel, Praktizierender Arzt für Sportmedizin und Chirotherapie, Schönebeck

Prof. Dr. W. Hänsel, Pharmazeutisches Institut der
Universität Kiel

Prof. Dr. J. Kult, Nephrologe, Bad Mergentheim

Prof. Dr. G. Linß, Ärztlicher Leiter der Klinik Hennigsdorf,
Akademisches Lehrkrankenhaus der Charité

Dr. T. Sautter, Chefarzt der Frauenklinik, Kreiskrankenhaus
Erbach, Gesundheitszentrum Odenwaldkreis, Erbach

Prof. Dr. J Schulz, Chefarzt der Geriatrischen Klinik,
Helios Klinikum Berlin-Buch

Prof. Dr. B. Weisser, Vorstand H. G. Creutzfeldt-Institut Kiel,
Direktor Institut für Sport und Sportwissenschaften Christian-Albrechts-Universität zu Kiel



http://www.journalmed.de/log.php?un=no& ... ktuellview




http://www.ncbi.nlm.nih.gov/pubmed/1141 ... d_RVDocSum



http://www.smw.ch/dfe/set_archiv.asp?ta ... /smw-09666




tino

 

[purecontrol]

Common Sense Osteoporosis Causes
Now lets check some other osteoporosis causes that relate to some common sense and proper functions of the body or an out-of-balance condition. The thyroid gland produces calcitonin, which participates in the regulation of parathormone and phosphate metabolism in the bones. Calcitonin also acts to regulate calcium levels in our bodies. Low calcium levels in the blood will inhibit the calcitonin output. Calcitonin is the single-chain polypeptide containing 32 amino acids.

The major mechanisms which pH controls are all biochemical reactions, hormonal and electrical energy. All are sensitive to pH and effect many human functions.

The complex biochemical processes taking place constantly is an attempt to keep blood pH as near perfect as possible. These are known as the pH buffering systems. These buffering systems need the balance of minerals (especially calcium) to work effectively and minerals have different pH levels at which they can be assimilated. The more perfect your pH range is the more minerals will be assimilated. If we are not getting an adequate mineral intake from the foods we eat, we will have problems balancing our pH system.

Calcium helps maintain pH balance by neutralizing the acids and toxins in the body. Calcium forms mono-ortho calcium phosphate that is the main buffering agent that maintains the acid and alkaline balance in the body. When the body is low or depleted in calcium and continually over acidic it will take some calcium from here and there from the bones or teeth to help buffer the condition. When it runs out of the calcium it will produce ammonia to help buffer, which you do not want.

Aluminum toxicity and its symptoms mimic those of Alzheimer's disease and osteoporosis, which may interfere with the metabolism of calcium. Read the pages on the thyroid gland, hydrogen potential for pH balance and Alzheimer's to avoid the types of aluminum to help and prevent osteoporosis.

Many will tell you what to do for treatment and for the prevention of osteoporosis and recommend your balanced diet rich in calcium and vitamin D but these are not the only nutrients your bodies need. You are told to take extra calcium supplements like calcium carbonate, oxalate or phosphate but taking too much of these types will build up as gull bladder or kidney stones and accumulate in the blood vessels as plaque.

Use calcium that is absorbable and high in other trace elements. The calcium that conforms to your electrical pathways and used most effectively are derived from vegetables or citrus.

Bone is about 9 percent calcium carbonate, and 85 percent tri-calcium phosphate, that are produced by phosphorus. Too much promotes calcium loss or too little Phosphorus encourages calcification.

Magnesium as magnesium phosphate is about 2 percent. Fluoride increases bone mass and about 4 percent of calcium fluoride is needed to harden bone. Silicon, usually taken as Silica that is another trace mineral that helps in the prevention of osteoporosis, Manganese helps to keep calcium soluble or bio-available. Zinc, assists with calcium absorption. Other minerals needed besides calcium for bones are Boron, Chromium, Cooper, and Manganese.

If you are young, you may only have to avoid the bad and eat the good to prevent any future degeneration due to osteoporosis. First the body has to be able to absorb the nutrients in the smaller intestine and colon into the blood stream. The older we become, the more important it is to detoxify, clean the colon for proper absorption and being able to assimilate the vitamins and minerals to make use of them. You should replenish your supply of lost nutrients with extra supplements. This is essential to rebalance all body functions to reverse osteoporosis.

Avoid all junk, processed, canned, refined foods, acid forming foods, alcohol, antibiotics, caffeine, cokes, dairy products, drugs that bind minerals and cause constipation or block absorption, hydrogenated oils, meat, mucus forming foods, pharmaceutical laxatives, products that contain aluminum, saturated fats, steroid drugs, table salt and sugar. Foods containing oxalic acid like beet greens, cranberries, currants, gooseberries, plums, spinach and rhubarb will bind calcium. Aspirin or other NSAIDs reduce magnesium, and eventually calcium levels.


http://www.oxymega.com/osteoporosis.html

 

[purecontrol]

Content removed because of legal threats from the owners of Betterbones.com to sue GourmetStyleWellness for copyright infringement, claiming they were losing search engine rankings because Google would penalize them for duplicate content across multiple domain names (here, on our forums), thereby causing them to "lose money". Even though the URL to their site was provided, enabling gourmetstylewellness.com users to purchase their products, I have removed the content and the URL, thereby actually causing them to lose out on sales.

You get what you ask for

[content deleted]

 

[purecontrol]

The pH Connection & Osteoporosis








We discuss pH in much more detail in other areas of the biomedx website, but right now we'll just give a brief glance at the role pH balance plays in osteoporosis. This is a very simplistic discussion.

As a part of normal metabolism, the body produces acids. When the body has an excess of acid it can't get rid of at the moment (due to acid excess or a lack of alkaline reserve minerals), the acid can get stored. Where does it get stored? Mostly in the interstitial spaces, also called the extracellular matrix - this is the space around the cells. As way of illustration, it can be said that when the body stores this acid in the extracellular matrix, it believes that one day, the acid is going to be removed. Therefore, in order to be in balance, it knows that for every molecule of acid that gets stored in the tissues, an equal molecule of bicarbonate or base substance needs to be put into the blood because one day it will need to escort the acid out of the body. This is the body's amazing compensatory mechanism at work. What we see here is the pH interplay between the blood and the tissues. If the body has an acid overload, it stores the acid in the tissues (the tissue pH decreases) and the blood compensates and becomes alkaline (the blood pH increases).

As the body degenerates further into ill health, the blood pH often will turn from it's overly alkaline condition and then start to move down. When that happens, the body is losing it's compensatory mechanisms. If the proper intensive intervention is not engaged, physical death will often ensue. But before that happens….

As more acid accumulates in our body, it gets stored and pushed further, and ultimately it can get pushed into the cell. When it gets pushed into the cell, the first thing it does is displace POTASSIUM and then MAGNESIUM and then SODIUM.

Wow. Those are three critical minerals in our body. The potassium and magnesium will leave the body. As potassium leaves it needs phosphate in the process and the body will get that from bone, the result is calcium is released and ends up as free calcium in the system. (As a preservation mechanism the sodium will be retained through the operation of the kidney). This calcium leaving the bone as phosphate is released to bind with potassium is something you don't want and it is a big part of what's behind osteoporosis, arthritic pain, etc. It is brought about by the body compensating for an ever increasing tissue acidosis and potassium loss somewhere in the body. What you might not want to do in this case is take more calcium supplements that won't be utilized down at the cellular level. With that said, you can now understand why most generic calcium products, antacids, etc. are one of the most over-prescribed supplements. In these situations what the body really needs is more of the right minerals to put potassium back in its place, more magnesium, and possibly zinc - like zinc picolinate - which lends help to the whole digestion process for making adequate levels of HCL in the gut so minerals can be broken down to begin with when you eat.

With a good understanding of the pH interplay in the body, natural answers can be derived for good health, including good bone health.




pH is not the whole story.


As mentioned earlier, this discussion would be very simplistic. Your body has specific homeostatic regulators that keep everything working and in balance. pH is but one--though a most important one. Another would be your sympathetic vs. parasympathetic system in relationship to your oxidative rate (how you metabolize food/nutrients). For some individuals with osteoporosis as mentioned above, calcium would be a secondary concern and more important might be potassium, magnesium, manganese, etc. How one breaks down their nutrients (fast oxidizers vs. slow oxidizers) would give another indication of which mineral supplements might be more important for osteoporosis management.

When you embark on your endeavor to manage osteoporosis risk, it is important that you consult a medical doctor or other healthcare provider that has your biological individuality in mind. These individuals rarely (if ever) prescribe pharmaceutical drugs with potential health harming side effects. These naturally oriented providers have a better understanding of basic nutritional concepts, natural osteoporosis management, metabolic typing and nutrient needs per individual requirements, along with other health supporting concepts.



http://biomedx.com/bones/page13.html

 

[purecontrol]

Saliva pH and Cancer
"When healthy, the pH of blood is 7.4, the pH of spinal fluid is 7.4, and the pH of saliva is 7.4. Thus the pH of saliva parallels the extra cellular fluid...pH test of saliva represents the most consistent and most definitive physical sign of the ionic calcium deficiency syndrome...The pH of the non-deficient and healthy person is in the 7.5 (dark blue) to 7.1 (blue) slightly alkaline range. The range from 6.5 (blue-green) which is weakly acidic to 4.5 (light yellow) which is strongly acidic represents states from mildly deficient to strongly deficient, respectively. Most children are dark blue, a pH of 7.5. Over half of adults are green-yellow, a pH of 6.5 or lower, reflecting the calcium deficiency of aging and lifestyle defects. Cancer patients are usually a bright yellow, a pH of 4.5, especially when terminal." The Calcium Factor: The Scientific Secret of Health and Youth, by Robert R. Barefoot and Carl J. Reich.

Virtually all degenerative diseases, including cancer, heart disease, osteoporosis, arthritis, kidney and gall stones, and tooth decay are associated with excess acidity in the body. While the body does have a homeostatic mechanism which maintains a constant pH 7.4 in the blood, this mechanism works by depositing and withdrawing acid and alkaline minerals from other locations including the bones, soft tissues, body fluids and saliva. Therefore, the pH of these other tissues can fluctuate greatly. The pH of saliva offers us a window through which we can see the overall pH balance in our bodies.

Cancer cannot exist in an alkaline environment. All forms of arthritis are associated with excess acidity. Acid in the body dissolves both teeth and bones. Whatever health situation you are faced with, you can monitor your progress toward a proper acid/alkaline balance by testing your saliva pH.

What does "Acid" and "Alkaline" mean?
Water (H2O) ionizes into hydrogen (H+) and hydroxyl (OH-) ions. When these ions are in equal proportions, the pH is a neutral 7. When there are more H+ ions than OH- ions then the water is said to be "acid". If OH- ions outnumber the H+ ions then the water is said to be "alkaline". The pH scale goes from 0 to 14 and is logarithmic, which means that each step is ten times the previous. In other words, a pH of 4.5 is 10 times more acid than 5.5, 100 times more acid than 6.5 and 1,000 times more acid than 7.5.

Acid and Alkaline Minerals and Foods
Minerals with a negative electrical charge are attracted to the H+ ion. These are called acid minerals. Acid minerals include: chlorine (Cl-), sulfur (S-), phosphorus (P-), and they form hydrochloric acid (HCl), sulfuric acid (H2SO4), and phosphoric acid (H3PO4). Minerals with a positive electrical charge are attracted to the negatively charged OH- ion. These are called alkaline minerals. Nutritionally important alkaline minerals include calcium (Ca+), (K+), magnesium (Mg+), and sodium (Na+). To determine if a food is acid or alkaline, it is burned and the ash is mixed with water. If the solution is acid or alkaline then the food is called acid or alkaline. Ash is the mineral content of the food.

Ways to Restore Acid/Alkaline Balance in Your Body
If your saliva is too acid you would benefit from increasing the alkalinity of your body. Ways to do this include:

1. Eat mostly alkaline foods.
The general "rule of thumb" is to eat 20% acid foods and 80% alkaline foods. Avoid the "strongly acid" foods.

Strongly Acid:meat, fish, soft drinks

Mild Acid: grains, legumes, nuts

Mild Alkaline: fruits, vegetables, berries, dairy

Strongly Alkaline: green leafy vegetables, brocoli, spinach

2. Supplement your diet with alkaline minerals.
Salts of the alkaline minerals cesium, rubidium and have been found by Dr. Brewer to be particularly effective in fighting cancer. Dr. Gerson, founder of the Gerson cancer therapy, " A Cancer Therapy: Results of Fifty Cases and the Cure of Advanced Cancer " (page 246) gave his patients a 10% potassium solution. Potassium tablets are commonly available. Potassium bicarbonate (KHCO3) can be used as a substitute for sodium bicarbonate (baking soda) when baking. You might try mixing a teaspoon of potassium bicarbonate with water and drinking it before going to bed each evening.

Another good source of information on the body ph problem is essence-of-life.com.


3. Supplement your diet with freshly made fruit and vegetable juices.
As a treatment for cancer, some doctors recommend one 8 oz glass per hour for every waking hour of the day. We could never eat the amount of nutrition we drink with these juices.



http://www.healingdaily.com/conditions/ ... h-test.htm

 

[squeegee]

bump!

 

[nograde]

I stumbled on a similar connection some time ago from a different angle (lipid peroxidation):

http://www.jbc.org/content/early/2009/08/05/jbc.M109.023572.full.pdf

Based on the above, and evidence that lipid oxidation increases with age (30), we hypothesized that increased lipoxygenase expression increases oxidative stress and reduces Wnt signaling, thereby decreasing the number of osteoblasts. We show that the expression of the lipoxygenases Alox12, Alox12e, and Alox15 increases in the bone of B6 mice with advancing age. These changes are associated with increased levels of lipid oxidation and increased expression of PPARγ. These same changes, along with increased oxidative stress and decreased Wnt signaling are reproduced in 4 mo old mice bearing a high expressing allele of Alox15. In addition, we present in vitro evidence for an oxidized PUFA-induced ROS/FoxO/PPARγ/β-catenin cascade. This provides a mechanistic explanation for how increased lipid oxidation can compromise the canonical Wnt signaling required for the differentiation and survival of osteoblasts.

There are only a few very significant systemic differences between bald and non-male pattern baldness people:

• Higher incidence of Coronary heart disease in male pattern baldness and higher levels of LDL/lipoprotein(a) in male pattern baldness[1,6]
• Higher levels of lipid peroxidation [2,3]

What are the possible connections?

• Lipid peroxidation seems to be potently induced by endotoxin(LPS) [4,5] (and possibly by highly oxidizable PUFAs found abundant in vegetable oils)
• LDL/Lipoprotein(a) seems to have inhibitory effects on endotoxin/LPS effects [7,8] (HDL also, but HDL seems to be lower in male pattern baldness)

If there's a systemic problem in male pattern baldness it seems to be related to fatty acid metabolism.
It could very well be that all the "nutheads" have been right all the time by saying that baldness begins in the gut (the major source of endotoxin).


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[1] http://onlinelibrary.wiley.com/doi/10.1111/j.1468-3083.1999.tb01001.x/abstract
The risk of coronary heart disease in men with androgenetic alopecia

[2]http://www.ncbi.nlm.nih.gov/pubmed/10965354
Antioxidants and lipid peroxidation status in the blood of patients with alopecia.

[3] http://www.lifesciencesite.com/lsj/life1001/030_11559life1001_204_209.pdf
Assessment of Zinc and Copper Contents in the Hair and Serum and Also Superoxide Dismutase, Glutathion
Peroxidase and Malondi Aldehyde in Serum in Androgenetic Alopecia and Alopecia Areata

[4] http://iai.asm.org/content/52/2/613.short

[5] http://europepmc.org/abstract/MED/3589967

[6] http://www.ingentaconnect.com/content/mjl/adv/2010/00000090/00000005/art00009

[7] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC108207/
Lipoprotein(a) inhibits lipopolysaccharide-induced tumor necrosis factor α production by human mononuclear cells.

[8] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164216/
Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

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Btw: http://digitool.library.colostate.edu/R/?func=dbin-jump-full&object_id=123369&local_base=GEN01
Dihydrotestosterone attenuates endotoxin, cytokine, and hypoxia-induced vascular inflammation

The results of these studies indicate that: 1) DHT increases COX-2 expression under unstimulated/physiological conditions via an AR-dependent mechanism. 2) DHT decreases cytokine-, endotoxin,-hypoxia, and HGD-induced COX-2 expression via an AR-independent mechanism. 3) DHT decreases cytokine-induced reactive oxygen species. 4) DHT decreases hypoxia-induced HIF-1α expression. 5) DHT decreases HIF-1α and TLR4 expression during HGD via an AR-independent mechanism. 6) DHT's effect to attenuate cytokine-induced COX-2 expression is ERβ-mediated.

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Regarding the gut/endotoxin connection. There was some talk on HLH titled: "Full REGROWTH 3 cases...on arthritis drugs, what's going on here?".

One of the mentioned drugs is Sulfasalazine which is also used for inflammatory bowel diseases.

http://en.wikipedia.org/wiki/Sulfasalazine:

Sulfasalazine, and its metabolite 5-ASA, are poorly absorbed from the gut. Its main mode of action is therefore believed to be inside the intestine.
In Crohn's disease and ulcerative colitis, it is thought to be an antinflammatory drug that is essentially providing topical relief inside the intestine. It does this via a number of mechanisms such as reducing the synthesis of inflammatory mediators known as eicosanoids and inflammatory cytokines. However, unlike glucocorticoids (another class of drug used in the treatment in inflammatory bowel disease), sulfasalazine is a mild immunosuppressant.

Inflammatory bowel disease leads to endotoxemia:
http://www.ncbi.nlm.nih.gov/pubmed/17206721 - Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease:

Patients with IBD show increased serum levels of endotoxin, LBP and sCD14. This alteration correlates with disease activity, with normal levels recovered after treatment, although less completely in Crohn's disease, and parallels a rise in proinflammatory cytokines, suggesting a contribution of bacterial products to the inflammatory cascade in these patients.

The other drug used in the "Full regrowth" cases is benoxaprofen, a potent 5-LOX inhibitor.

 

[Jacob]

It could very well be that all the "nutheads" have been right all the time by saying that baldness begins in the gut (the major source of endotoxin)

I've been hinting at or saying that for years. I don't think there's a "cure" there..but everything seems to begin in the gut and/or can be improved by good gut health.

Good post btw.

 

[nograde]

Possible PGD2/PGJ2 connection:

http://www.ncbi.nlm.nih.gov/pubmed/18028337
Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors.

In this study, endotoxin caused a sequential induction of membrane bound prostaglandin E synthase-1 and lipocalin-type PGD synthase (L-PGDS) in the mouse spinal cord.

http://www.sciencedirect.com/science/article/pii/S089158490900330X
Lipid peroxidation: Physiological levels and dual biological effects

Although many LPO products exert cyctotoxicity, sublethal concentrations of LPO products induce cellular adaptive responses and enhance tolerance against subsequent oxidative stress through upregulation of antioxidant compounds and enzymes. This adaptive response is observed not only for chemically reactive α,β-unsaturated carbonyl compounds such as 4-hydroxy-2-nonenal and 15-deoxy-delta-12,14-prostaglandin J[SUB]2[/SUB] but also for chemically stable compounds

http://www.ncbi.nlm.nih.gov/pubmed/15639643
15d-PGJ2: the anti-inflammatory prostaglandin?

15-Deoxy-Delta-12,14-prostaglandin J2 (15d-PGJ2) is the most recently discovered prostaglandin. This cyclopentanone, the dehydration end product of PGD2, differs from other prostaglandins in several respects. There is no specific prostaglandin synthase (PGS) leading to 15d-PGJ2 production and no specific 15d-PGJ2 receptor has been identified to date. Instead, 15d-PGJ2 has been shown to act via PGD2 receptors (DP1 and DP2) and through interaction with intracellular targets. In particular, 15d-PGJ2 is recognized as the endogenous ligand for the intranuclear receptor PPARgamma. This property is responsible for many of the 15d-PGJ2 anti-inflammatory functions. In this review, we summarize the current understanding of 15d-PGJ2 synthesis, biology and main effects both in molecular physiology and pathological states.

 

[Jacob]

The Europharma hair combo I take contains millet seed/miliacin:
[h=1]Triterpenoid miliacin inhibits stress-induced lipid peroxidation[/h]
http://link.springer.com/article/10.1007%2Fs10517-006-0252-7#page-1

http://www.livestrong.com/article/546606-millet-bowel-movements/

According to chef and nutrition consultant Rebecca Katz, millet has anti-inflammatory properties. The intestinal lining can become inflamed from conditions like ulcerative colitis, Crohn's disease, celiac disease or reactions to medications. The inflammation causes abdominal pain and can result in diarrhea. Although they are not a substitute for medical care, anti-inflammatory foods like millet may contribute to the healing process and help reduce the frequency or severity of symptoms.

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http://www.ncbi.nlm.nih.gov/pubmed/2082266

The efficacy of miliaceum (millet) oil in local application for the treatment of purulent wounds was studied for the first time. The oil is obtained from the waste products of millet processing. It was demonstrated in experiments on 55 rabbits with a model of a purulent wound that the studied preparation causes a marked anti-inflammatory effect, promotes rapid cleansing of the wounds from the pyonecrotic contents, and significantly activates the reparative processes. With the use of millet oil the term of wound healing reduced by 6-12 days on the average as compared to healing in treatment with buckthorn oil and Vishnevsky's ointment.

 

[squeegee]

Good ****ing post no grade! :band:now I need to digest all this!!

 

[IDW2BB]

Good ****ing post no grade! :band:now I need to digest all this !!

"now I need to digest all this" :laugh::laugh::laugh::laugh::laugh: