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Authors:
Shanshanwal, Sujit J. S.1 [email protected]
Dhurat, Rachita S.1
Source:
Indian Journal of Dermatology, Venereology & Leprology. Jan/Feb2017, Vol. 83 Issue 1, p47-54. 8p.
ABSTRACT
Background: Finasteride and dutasteride are inhibitors of the enzyme 5-alpha-reductase
which inhibits the conversion of testosterone to dihydrotestosterone. Dutasteride inhibits
both type I and type II 5-alpha-reductase while finasteride inhibits only the type II enzyme.
As both isoenzymes are present in hair follicles, it is likely that dutasteride is more effective
than finasteride. Aims: To compare the efficacy, safety and tolerability of dutasteride and
finasteride in men with androgenetic alopecia.
Methods: Men with androgenetic alopecia
between 18 and 40 years of age were randomized to receive 0.5 mg dutasteride or 1 mg
finasteride daily for 24 weeks. The primary efficacy variables were hair counts (thick and
thin) in the target area from modified phototrichograms and global photography evaluation
by blinded and non-blinded investigators. The secondary efficacy variable was subjective
assessment using a preset questionnaire. Patients were assessed monthly for side effects.
Results: Ninety men with androgenetic alopecia were recruited. The increase in total
hair count per cm2 representing new growth was significantly higher in dutasteride group
(baseline- 223 hair; at 24 weeks- 246 hair) compared to finasteride group (baseline- 227
hair; at 24 weeks- 231 hair). The decrease in thin hair count per cm2 suggestive of reversal
of miniaturization was significantly higher in dutasteride group (baseline- 65 hair; at 24
weeks- 57 hair) compared to finasteride group (baseline- 67 hair; at 24 weeks- 66 hair).
Both the groups showed a similar side effect profile with sexual dysfunction being the most
common and reversible side effect. Limitations: Limitations include the short duration of
the study (6 months), the small sample size and the fact that it was an open-label study.
Conclusions: Dutasteride was shown to be more efficacious than finasteride and the
side-effect profiles were comparable.
Shanshanwal, Sujit J. S.1 [email protected]
Dhurat, Rachita S.1
Source:
Indian Journal of Dermatology, Venereology & Leprology. Jan/Feb2017, Vol. 83 Issue 1, p47-54. 8p.
ABSTRACT
Background: Finasteride and dutasteride are inhibitors of the enzyme 5-alpha-reductase
which inhibits the conversion of testosterone to dihydrotestosterone. Dutasteride inhibits
both type I and type II 5-alpha-reductase while finasteride inhibits only the type II enzyme.
As both isoenzymes are present in hair follicles, it is likely that dutasteride is more effective
than finasteride. Aims: To compare the efficacy, safety and tolerability of dutasteride and
finasteride in men with androgenetic alopecia.
Methods: Men with androgenetic alopecia
between 18 and 40 years of age were randomized to receive 0.5 mg dutasteride or 1 mg
finasteride daily for 24 weeks. The primary efficacy variables were hair counts (thick and
thin) in the target area from modified phototrichograms and global photography evaluation
by blinded and non-blinded investigators. The secondary efficacy variable was subjective
assessment using a preset questionnaire. Patients were assessed monthly for side effects.
Results: Ninety men with androgenetic alopecia were recruited. The increase in total
hair count per cm2 representing new growth was significantly higher in dutasteride group
(baseline- 223 hair; at 24 weeks- 246 hair) compared to finasteride group (baseline- 227
hair; at 24 weeks- 231 hair). The decrease in thin hair count per cm2 suggestive of reversal
of miniaturization was significantly higher in dutasteride group (baseline- 65 hair; at 24
weeks- 57 hair) compared to finasteride group (baseline- 67 hair; at 24 weeks- 66 hair).
Both the groups showed a similar side effect profile with sexual dysfunction being the most
common and reversible side effect. Limitations: Limitations include the short duration of
the study (6 months), the small sample size and the fact that it was an open-label study.
Conclusions: Dutasteride was shown to be more efficacious than finasteride and the
side-effect profiles were comparable.
