Topical caffeine causes hair loss ?!

[Sirini]

i was reading this article (if the link dosn't work use google cache)
http://npntserver.mcg.edu/html/alopecia ... fHair.html

the important part:

Presumably, dihydrotestosterone inhibits energy production by keeping
phosphodiesterase relatively inactive and by suppressing various protein
(enzyme) synthetases. A relatively high concentration of cAMP may cause
premature termination of the growing stages of hair follicles. Repetition of such
processes over several years presumably transforms terminal follicles to vellus-
type follicles and ultimately causes baldnes. The diverse biologic effects of
cAMP are mediated through activation of a family of protein kinases, which
consist of a regulatory (R) and a catalytic (C) subunit; and when bound,
these kinases are not active. Cyclic AMP binds to the R subunit, (a binding
protein) for cAMP and subsequently releases the C subunit to form an active
enzyme. Therefore, the more cAMP available in the androgen-sensitive hair
follicles, the stronger the activation of the protein kinase. An increase in
cAMP concentrations in hair follicles would produce diverse effects on
various enzymes and reaction pathways. Inhibition of glycolysis - by the
action of the active C subunit on the enzyme phosphofructokinase - decreases
the energy available for the cell to maintain its metabolic functions (Figure
9). The same active subunit effectively slows posttranslational protein
synthesis and interferes with cell cycles at the C1 and S phases.36 These
combined effects of high cAMP concentrations could result in premature
completion of the anagen stage; and this, in turn, could yield follicles that are
thinner and shorter than those of normal terminal hair.35 Apparently, the
differences in sensitivities for androgens of various types of hair follicles reside
in the cAMP protein-kinase system. However; the specific effects of the cAMP
system on the metamorphosis of terminal hair to vellus hair must be studied
further.

ok , from searching google i understand that caffeine is a phosphodiesterase inhibitor and phosphodiesterase is the enzyme that breaks down cAMP, so caffeine leads to increased levels of cAMP , and as you can see from the above atricle "A relatively high concentration of cAMP may cause
premature termination of the growing stages of hair follicles. Repetition of such
processes over several years presumably transforms terminal follicles to vellus-
type follicles and ultimately causes baldnes" :freaked:

i'm no scientist , can some one explaine this ??
[/u][/b][/quote]

 

[Sirini]

anyone?

 

[powersam]

was some buzz awhile back about caffeine being good for hairloss topically. google and you shall find.

never heard anything about it causing hairloss topically.

 

[emery]

i strongly believe the correlation exist..

 

[Sirini]

PowerSam

i have been using Alpecin ASL (based on caffeine) for a long time..
after reading the above article i wonder if Alpecin causes hair loss istead of stopping it!

 

[ronaldkia]

well..i dont even drink coffee!?!? so how am i suppose to answer?

 

[Freestyle]

well..i dont even drink coffee!?!? so how am i suppose to answer?

He said 'topically'.


Please, please, please, please, please, please pour a cup of hot coffee on your head, Ronny...

Please, please, please... :woot:

 

[Wezz]

how about applying green tea topically ?

 

[ronaldkia]

what?? now who in their right minds would apply topical caffeine on their heads? why would someone do that? do these people also put cheese sandwitches on their heads instead of eating it? i dont understand.

 

[powersam]

oddly enough the fact that you don't understand does not surprise me.

 

[ronaldkia]

well powersam, i dont understand that you dont understand how come i dont understand. the guy says topical caffeine, ive heard of topical rogaine, topical acne medications, but topical caffeine?

 

[Private Ryan]

well powersam, i dont understand that you dont understand how come i dont understand. the guy says topical caffeine, ive heard of topical rogaine, topical acne medications, but topical caffeine?

don't worry mate... some people are slower... here... let me give you a little help...

http://www.alpecin.com/en/index.php

now do you love me?

 

[Sirini]

I still don't know wether Caffeine causes hair loss or not so i stopped Alpecin ASL as a protective measure...

 

[powersam]

dude this forum is not the only source of information available. try this.

google caffeine +hairloss and see what comes up