Use Of Thermobalancing Therapy In Ageing Male With Benign Prostatic Hyperplasia With A Focus On Etio

[Otis Mack]

Since BPH and Androgenetic Alopecia are concurrent conditions the etiology might be similar.

Yes...I know of dht but is there even something that precedes the dht in causing the BPH and Androgenetic Alopecia?

Well...I cant say but there is loss of blood flow in the enlarged prostate too...

The next study(on bone) strongly suggests loss of blood flow precedes loss of function.

https://www.ncbi.nlm.nih.gov/pubmed/25955095

CONCLUSION:
Aging-related decrease of the microcirculatory perfusion of the lumbar vertebral marrow preceded the loss of BMD and the onset of IDD, indicating their possible causal relationship.




Microcirculation problems in the prostate:

https://www.ncbi.nlm.nih.gov/pubmed/27960590


CONCLUSIONS:
The present study demonstrated that TT is effective for BPH, suggesting that blood circulation plays a crucial role in its cause.

The continuous heat exposure that does not exceed the normal body temperature terminates the trigger of BPH development, "micro-focus" of hypothermia,

and the following spontaneous expansion of capillaries. TT could be considered to be a useful tool in BPH treatment

 

[Otis Mack]

While most of us aren't women here, could this increase by exogenous estrogens explain the success MTF transgenders have in using estrogens and gaining hair growth?:

https://www.ncbi.nlm.nih.gov/pubmed/16752268


Preserved microcirculatory response to acute estrogen not reflected by exercise capacity.
Fogelberg M1, Löfman I, Carlström K, Freyschuss A, Henriksson P.
Author information
1
Department of Medicine, Ersta Hospital, Stockholm, Sweden.
Abstract
BACKGROUND:
To assess the acute effect of a single dose of 10 mg oral micronized 17beta-estradiol on microcirculation in postmenopausal women with and without coronary artery disease and its potential influence on exercise capacity.

METHODS:
Postmenopausal women (n=11) with coronary artery disease had symptoms of ischemic heart disease and at least 1 mm ST depression at exercise. Microcirculation was examined by vital microscopy, with and without the acute administration of estrogen in a placebo-controlled cross-over design. Exercise test was performed on bicycle. The microcirculatory findings were contrasted to those in 14 healthy postmenopausal women.

RESULTS:
17Beta-estradiol in serum and blood flow velocity increased significantly after acute oral estrogen administration both in women with coronary artery disease (p<0.001) and in healthy women (p<0.0001), with no significant difference between the two groups. No effect on exercise capacity or ST depression at exercise was detected.

CONCLUSIONS:
Previously reported data that a single dose of estrogen administered to postmenopausal women results in positive effects on exercise was not reproduced.

An increased peripheral microvascular flow velocity was detected in women with coronary artery disease and this increase was not accompanied by an increased exercise capacity.




https://academic.oup.com/ajh/article/14/S1/213A/137407


The estradiol-associated cardiovascular protection may therefore be due to functional or structural alterations of the microvasculature.

 

[Otis Mack]

A Microcirculatory Theory of Aging

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538209/

Me: when do microcirculatory problems start? Early adulthood

The saying by Thomas Sydenham, “A man is as old as his arteries” [81], holds true even more so in this day and age as factors of vascular aging are reported to be closely associated with chronological age.


Indeed, alterations in vascular mechanics and structure are related with vascular aging, resulting in less elastic arteries and diminished arterial compliance. Furthermore, the increased diffusion distance for oxygen caused by reduced capillary numbers and density, gives rise to heterogeneous perfusion [82], where the close proximity of perfused capillaries and non-perfused capillaries triggers alterations to oxygen extraction even when blood flow to the tissue is conserved [83]. Under normal physiological conditions, the microcirculatory blood flow is adapted to the metabolic levels of human tissues and organs, so the physiological functions of various organs in the human body can function as they should.

Once the microcirculation of the human body is impaired, cells would not be able to get enough nutrition and oxygen, and meanwhile, CO2 and metabolic products, including those that are toxic, cannot be removed and will accumulate.


re: oxygen part{{{ https://onlinelibrary.wiley.com/doi/10.1111/ijd.14193 }}}



Consequently, deterioration of physiological functions of cells and then organs that are necessary for survival and reproduction will occur.

Microcirculatory impairment arises in adulthood and becomes progressively impaired with aging; the corresponding tissue system or internal organs are affected and unable to function normally, which eventually lead to aging. Therefore, aging is the process of continuous impairment of microcirculation in the body.











The Effect of Aging on the Cutaneous Microvasculature

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461519/


Good microcirculation indicates increased lifespan

https://www.eurekalert.org/pub_releases/2016-09/sg-gmi_1090216.php

 

[Otis Mack]

The Microcirculation in Inflammation

https://www.sciencedirect.com/science/article/pii/B9780123745309000115



Inflammation and the Microcirculation.

https://www.ncbi.nlm.nih.gov/books/NBK53376/

The critical role of inflammation in diseases as diverse as atherosclerosis, diabetes, cancer, reperfusion injury, and Alzheimer’s disease [1–5] accounts for the massive research effort that has been directed toward understanding the mechanisms that initiate and regulate the inflammatory response.


The microcirculation plays a major in the genesis and perpetuation of an inflammatory response. The microvasculature undergoes a variety of functional and structural changes during inflammation.

These changes include a diminished capacity of arterioles to dilate, impaired capillary perfusion, the adhesion of leukocytes and platelets in venules, enhanced coagulation and thrombogenesis, an increased vascular permeability to water and plasma proteins, and an eventual increase in the rate of proliferation of blood and lymphatic vessels.

The net effects of these responses are to (1) promote the delivery of inflammatory cells to the injured/infected tissue, (2) dilute the injurious/inciting agents in the affected region, (3) isolate this region from healthy tissue and the systemic circulation, and (4) set the stage for the regenerative process.

 

[Otis Mack]

Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798701/



Hyperandrogenism and vascular dysfunction often coexist in women with polycystic ovary syndrome (PCOS). We hypothesized that testosterone compromises cutaneous microvascular dilation in women with PCOS via the endothelin-1 ET-B subtype receptor.


For example, both flow-mediated and nitrate-mediated vasodilation are attenuated in women with PCOS compared with healthy women of similar age (11, 28).

Moreover, total and free testosterone (T; the primary androgen elevated in PCOS), along with insulin resistance, are independent predictors of the impaired vasodilation (28).

Vascular dysfunction in the microcirculation impacts both vascular resistance and insulin-mediated glucose disposal in the periphery, thereby contributing to hypertension and insulin resistance.

Thus peripheral microvascular dysfunction is a key feature of cardiovascular disease risk associated with these chronic conditions (22).

 

[Otis Mack]

Minoxidil and male-pattern alopecia: a potential role for a local regulator of sebum secretion with vasoconstrictive effects?
Kurbel S1, Kurbel B, Zanić-Matanić D.
Author information
1
Department of Physiology, Osijek Clinical Hospital, Croatia. [email protected]
Abstract
Regulation of the hair cycle takes place at the pilo-sebaceous unit with the sebaceous gland as a sex hormone-dependent part. Although minoxidil stimulates proliferation of follicular cells and activation of prostaglandin endoperoxide synthase-1, it was suggested that other mechanisms, such as an increase in the local blood flow, might mediate the drug effect on hair growth. If that is the case, it is possible that minoxidil counteracts some vasoconstrictive mediator of male-pattern alopecia.

This hypothetical vasoconstrictive mediator X would have to meet some criteria: (I) vasoconstriction both in the general circulation and in the hair-growing skin; (II) local vasoconstrictive activity in the hair growing skin should be related to the circulating testosterone level; (III) only an increase in the local mediator X activity causes male-pattern alopecia, since hypertensive patients are not balder than expected.


The sebaceous gland is a possible place of the mediator X secretion since it is a sex-hormone-dependent part of the pilo-sebaceous unit. ET-1 might be a suitable candidate for the mediator X, since male hormones raise ET-1 plasma levels and female hormones lower them.

The speculation presented here is that ET-1, beside vasoconstriction in the general circulation, might also regulate the sebum secretion, by triggering contractions of the myoepithelial cells.

This hypothetical mechanism would normally remain confined to the sebaceous gland. During puberty, sex hormones stimulate growth of sebaceous glands in both sexes.

In women hypertrophied sebaceous glands under estrogen control would not increase its ET-1 content, while in men, testosterone would increase ET-1 secretion that might affect the neighboring arterioles.

Induced vasoconstriction might reduce the hair growth and promote hair loss. If ET-1 plays the described role, then an ET-1 antagonist, i.e. bosentane, should also have some hair-growing properties.

 

[Otis Mack]

Talk of VEGF and hair growth but not in Androgenetic Alopecia.

https://ojrd.biomedcentral.com/articles/10.1186/s13023-019-1166-6


Due to unknown aetiology of Thromboangiitis obliterans (TAO), its effectively treating is challenging.

However, angiogenesis induction is one of the acceptable treatments for TAO patients

Recently, we have noticed that TAO patients who were under long-term treatment with angiogenesis-inducing medication showed considerable improvement in terms of healing chronic ulcers over the course of one to 2 years of treatment.

However, some of them developed dermal gangrene despite the warming of their feet, with or without palpable pulses in the extremities, and with hair growth on the affected skin

 

[OtyMac]

In Benign Prostatic Hyperplasia, Decrease in Oxygen to Tissues Is Linked to Urinary Retention - BPH News

High expression of hypoxia-inducible factor (HIF) is a marker of proliferating prostate tissues and may predict a risk for acute urinary retention in benign prostatic hyperplasia (BPH) patients, according to a study, “Elevated expression of HIF-lα in actively growing prostate tissues is...

bphnews.com

Benign prostatic hyperplasia is one of the most common diseases in middle-age or older men, and is characterized by lower urinary tract problems and bladder outlet obstruction. An increasing number of studies report that benign prostatic hyperplasia is associated with hypoxia, a condition where there is a significant decrease in the amount of oxygen reaching the tissues.

 

[OtyMac]

Urology

Journal

symbiosisonlinepublishing.com

"Dr. Allen's research on the Origin of Diseases has helped him to identify the causal root of prostate enlargement, namely capillary expansion. This conclusion is based on 2 functional physiological properties of capillaries which are activated by an irritating factor, i.e., a trigger; indeed this peculiarity of capillaries explains the cause of chronic internal diseases. Constriction of capillaries in response to an irritating trigger develops local micro-hypothermia. It is this focus of hypothermia, which in turn becomes a constant irritant maintaining illness, i.e., making a disease chronic [12]."

Origin of Diseases Discovery by Dr. Allen Has Led to Creation of Thermobalancing Therapy Treating Chronic Pain and Ailments Successfully, States Fine Treatment

London, Grat Britain (PRWEB) July 09, 2013 -- ‘Dr. Simon Allen has created The Origin of Diseases Theory based on his profound medical experience. It explains...

www.prweb.com

Dr. Simon Allen has created The Origin of Diseases Theory based on his profound medical experience. It explains that chronic diseases are caused by the development of the capillary net, which grows so actively that it becomes a separate tissue impeding arterial blood flow in the affected organ or area of the body,’ points out Professor Ivan Aghajanyan in a recent interview to Panorama. The devices developed by Dr. Allen are based on this theory. Fine Treatment emphasizes that they are designed to provide an effective treatment for the cause of chronic conditions, such as prostate enlargement and chronic prostatitis, kidney stones, coronary heart disease and back pain.


The article, ‘Treatment of chronic diseases through Dr. Allen’s Device: An interview with Professor Ivan G. Aghajanyan’ in Panorama.am, dated June 24, 2013, reveals: “Dr. Allen believes that if the temperature in the affected organ is stabilized, it will improve blood circulation considerably, and ultimately lead to a regression of a chronic disease suffered by a patient. This is the essence of his theory, and is the basis of his treatment method. Therefore, the treatment with Dr. Allen’s Device is directed at the improvement of blood circulation in an affected organ.”

Head and Brain Treatment - Fine Treatment

Dr Allen's Device for Head and Brain Treatment: relieves chronic headaches and congested sinuses, stimulates memory and concentration

finetreatment.com

 

[OtyMac]

A gem of a study posted by Poppyburner adds more support to the microcirculation theory:

https://www.gourmetstylewellness.com/interact/threads/malocclusion-and-hair-loss-an-intimate-relationship-2019.130144/

Maybe this explains too why occipital hair follicles are fairly robust against balding. It is the STA artery that appears to be the problem by poor jaw clearance while the occipital artery is not effected by that.

It is clear that the Superior Temporal Artery (STA) [1-4] represents 85% of the vascular supply to the scalp, whilst the remaining 15% is provided by the Occipital Artery (OA)

However, in the instance of Class II Skeletal malocclusion, there is the possibility of reduced perfusion or occluded blood flow in the STA, due to the retrognathic architecture of the skull. Evaluation of the population reveals that hair loss is seen overwhelmingly among individuals with Class II skeletal profile, supporting the hypothesis that malocclusion leading to reduced vascular perfusion of the scalp in turn results in hair loss (Figure 2).

Of the one hundred individuals suffering from hair loss, direct visual, and observation of dental model occlusion demonstrated that ninety-six individuals had Class II dental malocclusion. However, a more thorough evaluation of the one hundred individuals, those with or without Class II dental malocclusion, through analysis of their skeletal cephalometric radiographs, reveals that all one hundred subjects selected for inclusion present with Class II skeletal malocclusion (Figure 4).

 

[OtyMac]

Blood flow changes of a superficial temporal artery before and after low-level laser irradiation applied to the temporomandibular joint area - PubMed

Low-level laser irradiation applied to the right TMJ area caused an expansion of blood vessels and an increase in blood flow volume. The same result on the contralateral side may be caused by the vasodilator reflex via the hypothalamic thermostat.

pubmed.ncbi.nlm.nih.gov

Conclusion: Low-level laser irradiation applied to the right TMJ area caused an expansion of blood vessels and an increase in blood flow volume. The same result on the contralateral side may be caused by the vasodilator reflex via the hypothalamic thermostat.

 

[OtyMac]

A Case of Moyamoya Disease Associated with Systemic Lupus Erythematosus

www.jkna.org

Moyamoya disease is a rare clinical entity, diagnosed by cerebral angiography and characterized by occlusion of the bilateral internal carotid artery system and development of collateral arteries. The etiology of moyamoya disease is unknown but some cases were reported to be associated with many other diseases such as hereditary, infectious, autoimmune, and metabolic disorders. A 16-year-old female was admitted with right side motor weakness, visual dis-turbance, malar rash, and emotional lability. Physical examination showed hair loss on frontal and bitemporal areas

https://www.ahajournals.org/doi/full/10.1161/01.str.27.10.1750

Conclusions Our findings suggest that moyamoya disease is a systemic vascular disease. The results indicate systemic etiologic factors that may promote the early development of intimal thickening in moyamoya disease.

 

[OtyMac]

Carotids lead to superior temporal artery...

Ischaemic scalp ulceration and hair loss

A 46-year-old woman presented to our outpatient clinic in June, 2013, with frequent collapse, ischaemic scalp ulcerations, and hair loss (figure). She had undergone carotid endarterectomy in 2005, after a small right hemispheric stroke, and had no other medical history apart from...

www.thelancet.com

We inserted an 8 × 24 mm balloon-expandable Express stent (Boston Scientific, Natick, MA, USA) to the stenosed left subclavian artery via the left groin (appendix). There were no complications. Postintervention transcranial Doppler showed an increase of 120% in the mean velocity of the left medial cerebral artery, from 40 cm/s to 88 cm/s after stenting.
At follow-up in December, 2013, the patient's dizziness and collapse had resolved. Her scalp lesions were almost healed, and hair growth had normalised (appendix).

 

[OtyMac]

Frontiers | High-Sensitivity C-Reactive Protein Is a Predictor of Coronary Microvascular Dysfunction in Patients with Ischemic Heart Disease

BackgroundInflammation and microvascular dysfunction (MVD) are independently associated with adverse cardiovascular outcomes in patients with ischemic heart ...

www.frontiersin.org

Background: Inflammation and microvascular dysfunction (MVD) are independently associated with adverse cardiovascular outcomes in patients with ischemic heart disease. This study aimed to assess the relationship between inflammation, MVD, and myocardial injury.

Conclusion: hsCRP is a significant predictor of MVD while MVD is associated with myocardial injury, supporting the central role of inflammation and MVD in the pathophysiology and complications of coronary artery disease.

 

[OtyMac]

NLRP3 inflammasome as a key driver of vascular disease

Abstract. Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular innate immune receptor that

academic.oup.com

 

[OtyMac]

Is Early Onset Androgenic Alopecia a Marker of Metabolic Syndrome and Carotid Artery Atherosclerosis in Young Indian Male Patients? - PMC

Androgenic alopecia (Androgenetic Alopecia) is a common cosmetically and psychosocially distressing condition. High androgen level contributes to the development of atherosclerosis, thrombosis leading to hypertension and hypercholesterolemia. To study the ...

www.ncbi.nlm.nih.gov

Dogramaci et al.[53] on the other hand, found an association between severe androgenetic alopecia and a higher carotid intima-media thickness, although they did not analyze the prevalence of atheromatous plaque either

Medicine that slows balding may turn stiff vessels supple, helping vital organs

A medicine that slows balding and stimulates hair growth also may make stiff vessels more stretchy and improve blood flow to vital organs like the brain, according to an experimental model study.

www.sciencedaily.com

ORAL minoxidil is what they were using:
"Minoxidil not only lowered blood pressure, but also increased arterial diameter and restored carotid and cerebral blood flow. Minoxidil also reduced functional arterial stiffness and increased arterial elastin content," Dr. Shoykhet says. "Equally important, these beneficial changes persisted weeks after the drug was no longer in the bloodstream. The sustained improvements and the increased elastin gene expression suggest that minoxidil treatment may help remodel stiff arteries. Such remodeling may benefit humans whose elastin insufficiency is due to either advanced age or genetic conditions."

The study team notes that additional clinical studies are needed to confirm changes in blood flow to end organs in humans and to evaluate blood-flow differences in other key vascular beds impacted by elastin insufficiency, such as in the heart, kidneys, lungs and gut.

THE EFFECT OF SEX HORMONES ON ARTERIAL STIFFNESS​

Sex differences in mechanisms of arterial stiffness - PMC

Arterial stiffness progressively increases with aging and is an independent predictor of cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the time course of aging‐related arterial stiffness and the associated ...

www.ncbi.nlm.nih.gov

The direct effects of oestrogen on arterial stiffness over the lifespan have begun to be explored. Prepubescent females have less compliant arteries, as measured by carotid‐femoral PWV, and higher pulse pressure than their male counterparts (Ahimastos, Formosa, Dart, & Kingwell, 2003). After puberty, arterial stiffness decreases in females and increases in males, providing further evidence supporting sex hormone effects on vascular stiffness in addition to suggesting a potential effect of overall body/aortic growth on arterial stiffness.

How to Reduce Your Risk of Arterial Stiffness

Recently I came across several articles concerning new research on arterial stiffness. One of the latest appeared in the April issue of the American Journal of […]

atcormedical.com

How does arterial stiffness speed up aging?​

Among healthy young people, the large arteries that run from the heart to the major organs remain open and supple, while the smaller arteries are stiffer. This difference in stiffness is important because it helps dampen the large pressure waves that are produced every time the heart beats.

The result is a smoother flow of blood and protection for the tiny fragile blood vessels—capillaries—against damage that can be caused by high pressure. The protected capillaries can then better nourish the tissues they serve.

As we get older, however, the larger arteries begin to stiffen as a result of years of exposure to inflammation, blood glucose, and other factors. As the larger arteries stiffen, the pressure dampening effect weakens and places pressure on the capillaries. (17,51,52)

At the same time, the increasing arterial stiffness results in higher blood pressure, which then causes more stiffening. The vicious cycle of aging, high blood pressure, and arterial stiffening is now in full swing. Once the capillaries are unable to function normally, the organs they nourished become damaged. That’s when we see heart attack, dementia, stroke, kidney and liver disease, and more.

 

[OtyMac]

Role of inflammation in the pathogenesis of arterial stiffness - PubMed

Increased arterial stiffness is an independent predictor of cardiovascular disease independent from blood pressure. Recent studies have shed new light on the importance of inflammation on the pathogenesis of arterial stiffness. Arterial stiffness is associated with the increased activity of...

pubmed.ncbi.nlm.nih.gov

Recent studies have shown that reductions in inflammation can reduce arterial stiffness. In patients with rheumatoid arthritis, increased aortic pulse wave velocity in patients was significantly reduced by anti tumor necrosis factor-α therapy. Among the major classes of anti hypertensive drugs, drugs that block the activation of the RAS system(LIKE spironolactone) may be more effective in reducing the progression of arterial stiffness.

 

[OtyMac]

Mechanisms of central arterial stiffening​

​

The role of collagen and elastin​

Vessel wall compliance is dependent on the status of two major scaffolding proteins: collagen and elastin5. Normally, there is a tightly regulated balance between synthesis and degradation of these two proteins.

Anomalies occur in this regulatory system such as that which accrues from inflammatory change where collagen is over produced and elastin synthesis is undermined28. Such asymmetry contributes to arterial stiffening. In addition, increased luminal pressure (such as in hypertension) also tends to favor collagen production at the expense of elastin29.

Indeed, histological examination of arterial tissue post-mortem appears to confirm that between the ages of 20 and 90 (the widest range of human longevity), there is doubling or tripling of the thickness of the tunica media15, 30. When stiffened vessels are examined microscopically, a striking array of histological changes are observed. These include abnormal and disorganized endothelium, increased collagen, fragmented and diminished elastin, infiltration of smooth muscle cells, infiltration of macrophages, infiltration of mononuclear cells and increased matrix metalloproteases5, 31. In addition, there is also an increase in transforming growth factor (TGF)-β, intercellular adhesion molecules (ICAM)s and cytokines in the vessel wall. Superimposed on thickening of the wall, there also appears to be a steady increase in vessel diameter with advancing age amounting to about 9% per decade from 20 to 60 years in the ascending aorta32.

 

[OtyMac]

WO2002100280A1 - Treatment of alopecia - Google Patents

The invention provides a method for treating baldness by performing one or more surgical procedures that enhances vascular blood flow to the scalp. The surgical procedure may include a bypass operation to increase blood flow through a particular artery, preventing or reducing blood flow through...

patents.google.com

Treatment of alopecia​

Abstract​

The invention provides a method for treating baldness by performing one or more surgical procedures that enhances vascular blood flow to the scalp. The surgical procedure may include a bypass operation to increase blood flow through a particular artery, preventing or reducing blood flow through an arterio-arterial or arterio-venous shunt respectively thereby redirecting blood flow, reducing a bony obstruction to blood flow, removing an obstruction in one or more arteries supply blood to the scalp, sympathectomy and use of a device to prevent vascular collapse, for example preventing collapse of an artery providing blood flow to the scalp.


The above descriptions of procedures are by no means comprehensive of the options available to a surgeon for enhancing the blood supply to the scalp. Any two or more of the above procedures may be used in combination where indicated. The inventor has surprisingly found that the improvement of blood supply to the scalp will result in improved hair growth or the return of hair growth. The invention may also prevent loss of hair growth thus preventing baldness or limiting an extent of baldness. In one case, a patient who had been bald for some fifteen years displayed hair growth subsequent to surgery which improved the perfusion of his scalp. A surgeon may additionally or alternatively rely on endolumenal techniques for enhancing blood supply to the scalp. These techniques may include dilation techniques such as balloon angioplasty.

 

[OtyMac]

More on arterial stiffness which destroys capillaries:

Killing me un-softly: Causes and mechanisms of arterial stiffness Recent Highlights of ATVB: Early Career Committee Contribution - PMC

The aorta is a blood vessel that provides a low resistance path for blood flow directed from the heart to peripheral organs and tissues. However, the aorta has another central hemodynamic function whereby the elastic nature of the aortic wall ...

www.ncbi.nlm.nih.gov

This could be the reason why even pre-pubertal children can rarely(fortunately) experience male pattern balding.

Aortic stiffness and left ventricular diastolic function in children with well-functioning bicuspid aortic valves - PubMed

Even children with well-functioning isolated BAV have abnormalities in aortic elasticity and diastolic function when compared with the Control group. However, a relationship between the two could not be established.

pubmed.ncbi.nlm.nih.gov

Conclusion: Even children with well-functioning isolated BAV have abnormalities in aortic elasticity and diastolic function when compared with the Control group. However, a relationship between the two could not be established.

Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance - PubMed

Microgravity (microG)-induced orthostatic intolerance (OI) in astronauts is characterized by a marked decrease in cardiac output (CO) in response to an orthostatic stress. Since CO is highly dependent on venous return, alterations in the resistance to venous return (RVR) may be important in...

pubmed.ncbi.nlm.nih.gov

It looks like Chris Hadfield experienced male pattern balding in space.

Hair grows slower or may stop growing completely in space

Hair from 10 astronauts was collected while they were on the International Space Station before being analysed by scientists based at Japan's Aerospace Exploration Agency.

www.dailymail.co.uk