Will Upping Duta Dosage To 2mg Help?

[con1000]

Taking 0.5mg at the minute but still slipping... Wondering would 1mg a day be of benefit or is it pointless to increase dosage ?

 

[NorwoodingMyWay]

2.5mg is moderately more effective.
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Because it acheives steady state faster than 0,5mg. If you wanted my advise OP, stick to the recommended dose. These drugs are no candy.

 

[NorwoodingMyWay]

No, because it inhibits 10% more DHT. I agree with you though to stick with .5mg.

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The DHT it suppresses at 2.5 is 5AR Type 1, which plays no known roles in Androgenetic Alopecia. 5AR Type 1 is found in considerable amounts in the brain, and 0.5 mg inhibits 51% , while 2.5mg inhibits 88% if it. The study shows only 6 months, which suggests that 2.5 is only supperior because it started working alot faster (if the study was longer, the 0.5mg dose would catch up to the 2.5mg dose). Dutasteride is 2-3 times more potent at inhibing 5AR Type 2 (the one involved in balding, which is theorised as to why it's quite superior to finasteride), and more than 100 times potent at inhibiting 5AR Type 1 than Finasteride.

 

[NorwoodingMyWay]

Umm.. You're confusing 5AR with DHT. Forget about 5-AR type one and 2, this study measures how much DHT it inhibits. There is only one type of DHT, and by whatever mechanism you want to claim, 2.5mg decreases DHT by about 10% more than .5mg.

You can't seriously claim that the higher dose only inhibits more DHT temporarily when both drugs have reached saturation by week 4 and maintain that through 24 weeks. Just admit that the higher does is slightly more effective. I'm not saying it's worth it. The extra benefit isn't enough to be worth the exchange of more 5-AR inhibition, and the financial expense too.

No, no you misunderstood me my friend. 2,5mg is indeed more effective at the suppresion of DHT, but it all stems from the suppression of more 5AR Type 1. There currently 3 known isoenzymes of 5ARs : Type 1,2 and 3. Finasteride inhibits type 2 and 3, and because type 2 is the most predominant in prostate and genital skin, it consists of 2/3 to 3/4 of all DHT in the body (its why Finasteride blocks roughly 70% of DHT value). dutasteride on the other hand, blocks all 3 types, bringing the suppression to the 90s%, i read studies and graphs shown by the late Bryan Shelton (a well known and one of the most knowledgeable members here to date), DHT is not only 1 type, each 5AR type catalyzes DHT to different bodily tissues. You know about the Pseudohermaphrodites, males born with malfunctioned 5AR Type 2, they always had normal Testostetone, and normal 5AR Types 1, but because they lack the majority of their DHT from non functioning 5AR Type 2, they are born with embiguious genetilia and don't develop male characteristics until puberty. They never developed Androgenetic Alopecia and acne, and their prostate remained small throughout their lifetime. All in all, it tells us one thing : that different 5AR types catalyzes DHT into different places, and there is a reason noone is born with a 5AR type 1 difficency to date..

 

[NorwoodingMyWay]

Ok, well DHT is still DHT, but yeah different types of 5-AR are prevalent in different tissues, so by inhibiting type 1 you get less DHT in the liver, versus less in the prostate with type-2. The study I referred to measured overall serum DHT. I'm not aware of a study comparing these two doses of dutasteride on scalp DHT inhibition. There is a chance that there is no additional inhibition of scalp DHT, but given the difference in hair counts at 6 months I'd say it's a good bet that you are getting additional inhibition of scalp DHT with the higher dose. DHT is reduced by almost 90% after 1 day on .5mg dutasteride, so you can't chalk up the hair count difference to the higher dose bringing DHT down faster.

It's all steady state my friend ( i.e How much do you ingest vs how much is excreted from your body). Ultimately, ingesting 5 pills of dutasteride a day will have faster effect as opposed to 1 a day, but it doesn't mean it's necessarily better in the long term. Anyhow, sticking to the recommended amount is always better.

 

[Slid]

2mg duta what are you,a mammoth?I literally started taking duta yesterday and im already feeling how much more powerful it is compared to fina.Not even sure if I should take it ED.

 

[NorwoodingMyWay]

You only need 1 dose to reduce DHT by nearly 90%. If DHT is already reduced by the maximum after 1 day then what does it matter if the drug has reached steady state or not, which if I remember correctly only takes about two weeks at .5mg? The point is to reduce DHT, and it doesn't have to reach steady state to reach peak efficacy.

Where did you read that 1 pill of dutasteride blocks 90% of DHT ??

 

[Wisemiller]

There will be no significant difference. Of course your slipping, there is no such thing as a pill that stops male pattern baldness. Dutasteride may be moderately effective at slowing it down.

 

[StevenGerrard]

2mg duta what are you,a mammoth?I literally started taking duta yesterday and im already feeling how much more powerful it is compared to fina.Not even sure if I should take it ED.

lol I came here to say this

there is no way in hell anyone can function normally on such a high dose (2mg/ED).