Italian Hair Loss Lotion To Hit The Market In 2016

[Afro_Vacancy]

Do you think that DGLA might work in similar way to minoxidil? Brotzu said that he doesnt know why and how exactly DGLA works for regrothw. I see there many similarities.

No idea, but DGLA is replacing PGE1, and I think I once read that minoxidil is related to PGE1 but I can't find the source anymore so maybe that's not the case.

This person says that minoxidil upregulates PGE1
https://www.gourmetstylewellness.com/intera...n-enigma-experimental-topical-solution.90329/

I'm now using minoxidil, RU, castor oil, and stemoxydine. It will be great if I can quit them all within a few months of this formula coming out.

 

[Sanchez1234]

No idea, but DGLA is replacing PGE1, and I think I once read that minoxidil is related to PGE1 but I can't find the source anymore so maybe that's not the case.

This person says that minoxidil upregulates PGE1
https://www.gourmetstylewellness.com/intera...n-enigma-experimental-topical-solution.90329/

I'm now using minoxidil, RU, castor oil, and stemoxydine. It will be great if I can quit them all within a few months of this formula coming out.

Hi David, i want to send PM off topic but this is not possible on gourmetstylewellness.com? I am new here but i can't seem to PM other members

Anyway why are you taking only 0,3% Ru?

 

[Afro_Vacancy]

Hi David, i want to send PM off topic but this is not possible on gourmetstylewellness.com? I am new here but i can't seem to PM other members

Anyway why are you taking only 0,3% Ru?

Percentage is irrelevant, the real number that matters is mg. I take 15 mg.

I'm trying a very low dose because I'm worried about side effects. I have erectile dysfunction. I will try this for six weeks and see what happens.

 

[Sanchez1234]

Percentage is irrelevant, the real number that matters is mg. I take 15 mg.

I'm trying a very low dose because I'm worried about side effects. I have erectile dysfunction. I will try this for six weeks and see what happens.

Keep me posted! I had gyno from 0,25mg finas so i am looking for other (expirmental) drug to do.

 

[Pray The Bald Away]

Here's a new interview with Dr. Brotzu.
http://bellicapelliforum.com/dermatologia/dott-brotzu/
I'm hopeful, yet skeptical of some of his claims. The explaination for the lack of photos and s-equol's method of action seemed lacking/misinformed.

 

[rlf]

Hm, I don't know. I'm over 30 and finasteride has kept my hair for 16 years until this year. If I get 1-2 years back, it would be perfect. So the onset was long ago, but the hair was kept alive for 16 years. Hope this will work for me still?

 

[kuba197]

IMO everything seems legit. Let just say he explained that s-equol bind dht. That's all.
Just give it to my hands!

 

[Pray The Bald Away]

IMO everything seems legit. Let just say he explained that s-equol bind dht. That's all.
Just give it to my hands!

Yeah, I'm hoping he just misspoke. And are you Lewandowski?

 

[kuba197]

And he compared DGLA to minoxidil. In previous interviews he pointed out that it beats minoxidil in effects.

 

[ReasonableMan]

Any update on expected release? Couldn't see how to translate the page.

And he compared DGLA to minoxidil. In previous interviews he pointed out that it beats minoxidil in effects.

Even if it only matches minoxidil, we'd all benefit. I'd snap their hand off - but then I can't use minoxidil.

 

[papa pinrel]

Just one question guys, srry if u have said it before, would this equol have sides like finasteride?

 

[Afro_Vacancy]

Just one question guys, srry if u have said it before, would this equol have sides like finasteride?

Not necessarily.

finasteride blocks all 5AR, which affects a large number of hormones including DHT. By blocking T-DHT, finasteride increases both testosterone and estrogen.

Equol neutralizes DHT (I think), it doesn't destroy DHT. Further, this is a topical equol so we don't know if it will have any affect on DHT in the blood. Finally, half the population of Asia naturally produces equol, and we don't hear about half of Asians having ED, brain fog, and depression.

 

[Afro_Vacancy]

Google Translate Part 1, figure captions included but not figures, broken down into two parts due to gourmetstylewellness.com's 10,000 character limit.

Dr. Brotzu - Exclusive interview for Bellicapelli

Exclusive Interview with Dr. Brotzu for Bellicapelli. Here are the questions that we asked and to which he kindly responded.



1. What, in his view of the expectations that a suffering from Androgenetic Alopecia should have about your product?
2. Do you believe that this product has the potential to eliminate the problem of androgenetic alopecia?
3. Based on testing conducted by her and her opinion on the matter, which could be an average recovery potential margins and regrowth areas afffette by Androgenetic Alopecia, which are miniaturized hairs or even vellus / invisible?
4. In the case of Androgenetic Alopecia, care will have to continue "for life", or can be suspended and even terminated?
5. According to the experimentation and experience she conducted in patients suffering from Androgenetic Alopecia, which were the subjects who responded better to treatment in terms of gender / age?
6. According to the experimentation and experience she conducted in patients with Alopecia Areata, which were the subjects who responded better to treatment in terms of gender / age?
7. At present, one can predict or simply assume a very approximate date for the commercialization of the drug? What are the timelines for trials by Phidias?
8. To date, we could only see photographic documentation related Alopecia Areata.
Since statistically the number of subjects to Androgenetic Alopecia is significantly greater than that affected by Alopecia Areata, it would be possible to know if they are available and undisclosed photographic documentation for this disease? If not possible, you would know to give us a reason?
9. Given that the lotion will consist of: Diomo-gamma-linolenic acid (DGLA), carnitine, s-equol, transported within cationic liposomes, which (of course excluding their interaction) between these four components (DGLA, equol , Carnitine, cationic liposomes), in the case of Androgenetic Alopecia, believed to be the real discovery of his strength?
10. According to its experimentation and according to the documentation and experience accrued, how each component (DGLA, equol, carnitine) would act on miniaturization characteristic of androgenetic alopecia process?
11.Il preparation was effective of Androgenetic Alopecia, even without the presence of equol (which should have added later)?
12. Since the equol an anti-DHT and not having Alopecia Areata an androgenic component, considers that the equol was added because the only PGE1 (or alternatively its precursor DGLA) was not effective in cases of Androgenetic Alopecia ?
13. His experimentation done either with the use of PGE1 than with that of its precursor, ie the DGLA, showed substantial differences in results regarding Androgenetic Alopecia?
14. There have been side effects, and if so, what kind?
15. Do you believe that the product has a good chance of being marketed?
16. Believes that there are aspects and / or reasons demonstrating that the product could not be placed on the market and if so, which ones?
17. Do you think your preparation can be further enhanced / improved in the future?
18. The lotions will be different according to the type of alopecia which is hit by the patient (Androgenetic Alopecia or AA) by way of the equol component which would play action anti dht?
19. For what the product would differ from a topical classic antidht?
20. For his own experience or not, believes that in patients who have undergone a hair transplant the skin affected by grafts can benefit from its discovery by recovering indigenous hair or in this case the bulbs may have suffered excessive damage following transplantation and therefore can not be recovered?

 

[Afro_Vacancy]

Google translate part 2:

ANSWERS OF DR. BROTZU TO QUESTIONS OU R

The answer to your question is complex and it is almost impossible to answer all individually. I must point out the lotion mechanism of action and on what principles it is based.
The alopecia (androgenetic alopecia totalis and) have the base of a blood flow deficit at the level of capillaries that reach the hair follicles and carry oxygen and everything that is necessary for their metabolism and hair growth ..

The capillaries are composed of a layer of endothelial cells that separate the tissues from the blood flow. Endothelial cells are affected by many stimuli and certain stimuli reduce the flow in the capillaries and block their reproduction by reducing the microcirculation.
Logically stimuli can be very different from each other in the various types of alopecia, but all act on the microcirculation which supplies called hair bulbs.
I am attaching the capillary pattern

The cell reproduced in the foreground is called pericyte and is the one that regulates blood flow in the capillaries. Minoxidil acts on it which increases the flow in the capillary but this drug does not act on endothelial cells that were affected in many stimuli such as infectious, hormonal disorders ect.
The Prostaglandin E1 (PGE1) that acts both on pericytes on endothelial cells by determining their vasodilation and stimulating the reproduction of the latter.
About 6 years ago, we observed that the cationic liposomes carrying PGE1 were able to reduce the androgenic alopecia phenomena. (For completely unrelated reasons not made any research).


Dr. Brotzu

About 4 years ago we developed a lotion containing cationic liposomes carrying PGE 1, S-equol and Carnitine and began to experiment on people with androgenetic alopecia and then was tested on a child with alopecia areata. The results were excellent and surprising
The PGE1 improved microcirculation, the s-equol blocked the 5-α- reductase preventing testosterone from turning the dihydrotestosterone and carnitine enters the beta-oxidation of lipid chains facilitating metabolism.


Dr. Brotzu

It is seen that each hair bulb has a capillary that reaches it.
Since PGE1 is a product that is considered a drug has tried to replace it with its biochemical precursor which is the Dihomo-gamma-linoleic acid (DGLA). The results were equal if not better than those of the lotion with PGE1. There are scientific publications reporting that in cell cultures the DGLA stimulates the production of keratin. Therefore relying on these observations we started a trial with a lotion containing DGLA in place of PGE 1 of female persons with androgenetic alopecia. The results were published in "The Dermatologist" Year XXXVII 'N' 1/2015 'page March 26. Currently I know that there is an ongoing trial of 60 people with androgenetic alopecia and I have an ongoing trial of 18 people with alopecia totalis or areata.
Now I answer your questions:
Questions 1, 2 and 3. The lotion works very well when it begins to manifest alopecia, in people under the age of 30 will have good results with total stop of the fall and re-growth of hair and miniaturized hairs or even vellus / invisible resume a normal appearance. Logically, the treatment starts to give clear results after about 30 days and must be prolonged for many months.
Question 4. In our experience once you get the positive result I think it is appropriate to repeat the treatment at least three took a year or have a maintenance therapy twice a week
Question 5. Patients who responded better to have younger ones and in which androgenetic alopecia had risen recently (less than 2 years). There was no difference between the sexes.
Question 6. Subjects with less than 15 years responded better, but also subjects up to 25 years responded in an excellent way. Less in patients over 40 years. In young patients there was no difference between the sexes.
Question 7. I have no information and I can not answer that question.
Question 8. In the early days of the trial the collection of photos was random, and did not ask for permission to individuals to show and play photos. The only pictures available are those reported in the journal "Dermatologist". I then I started to take care of alopecia areata and I stopped being interested in androgenetic alopecia leaving this task to others. The only people who suddenly have friends and I ask their permission for the publication of the photos.
Question 9 and 10. In the foreword I tried to explain how the lotion. The cationic liposomes of small size adhere in a stable manner to the DLGA scalp acts on endothelial cells making it more elastic and stimulating the reproduction and increasing their functionality, also it has the power to stimulate the production of keratin; the equol preventing testosterone from turning into diidrotesterone, reduces the biochemical action of this; carnitine facilitates the metabolism of lipid chains facilitating the beta-oxidation of these and facilitating tissue metabolism. Therefore, stable adherence of cationic liposomes, the actions of DGLA on endothelial cells and stimulation to produce keratin, the dell'equolo action on testosterone and carnitine action on metabolism, all four together, stimulate the still existing called hair bulbs to return to their normal functions,
Question 11. The preparation has proven effective even without equol, but its effectiveness with equol in my judgment produces increase of 80%.
Question 12. Alopecia areata is caused by many different stimuli on the microcirculation, but often occurs in puberty associated with hormonal changes that occur during this period, especially in females. The PGE 1 and its precursor DLGA work but are boosted dall'equolo. The only PGE1 and DGLA are also effective alone in androgenetic alopecia but if you associate the equol it has a greater effect.
Question 13. There are no substantive differences between PGE1 and DGLA.
Question 14 There were no side effects.
Question 15 The product should be placed in the trades will end when the trials are ongoing.
Question 16. How I know there are no issues or reasons to block it from being marketed.
Question 17. At present we do not believe that we can make improvements, but everything evolves.
Question 18 and 19. We believe the current state of the experiences that there is no need to have different products for Androgenetic Alopecia and AA patients. The equol, as I said in response to question 10, is also beneficial in AA because often this occurs in combination with hormonal changes buoyancy.
Question 20. We have given the lotion to a patient who had had a hair transplant and we have observed that there was an increased hair and their growth rate, but on this subject in the future you will be able to run trials, but at present the information I have too few.

I must make a basic commentary.
I responded briefly to your questions, but to provide all the scientific data that are behind the emergence of various alopecia and reason to practice therapy should write a chapter of a university text reporting the data and all the bibliography on the various arguments. Being a university professor of vascular surgery in retirement I'm not going to dedicate myself to writing trichology chapters.

 

[abcdefg]

Isnt s-equol kind of expensive and hard to obtain? No one really makes it right now otherwise everyone would already be trying it.
For me stopping hair loss is most important so that means stopping androgens safely. I dont care for minoxidil or other growth agents, just keeping hair.

 

[ReasonableMan]

We can't try the dgla component? Think I remember reading that a special kind of delivery method was required.

 

[inmyhead]

Sounds nice, just need to wait some time...

 

[Pavi]

You guys are crazy if you're not excited about this; an esteemed Doctor developing a topical (potentially out next year) that can stop hair loss and give "impressive regrowth." I'll be honest, if you're a NW3 or under this could be HUGE for you (me)

 

[Follisket]

Okay but ...

I then I started to take care of alopecia areata and I stopped being interested in androgenetic alopecia leaving this task to others.

You simply stop being interested in a $7 billion market?
Anyway, still hopeful - though I've yet to hear how they inted to come up with that much S-Equol.

Also, I'm very happy to see people have finally started asking about the interaction between upcoming treatments and hair transplants. Would be wonderful to know you could make the most of your present without the fear of risking your future.

 

[kuba197]

Okay but ...


You simply stop being interested in a $7 billion market?
Anyway, still hopeful - though I've yet to hear how they inted to come up with that much S-Equol.

Also, I'm very happy to see people have finally started asking about the interaction between upcoming treatments and hair transplants. Would be wonderful to know you could make the most of your present without the fear of risking your future.

To be honest I would also be more interested to help fully bald children than 40 years old, healthy guy. Just imagine if you are 12 years old girl and you have no hair... This is depressing.