P-3074 (polichem Topical Finasteride) Phase Iii Just Ended.

[Arrade]

True, but again if finasteride caused cancer some men would still use it because its the only and best option available. Criticizing the one and only best treatment doesnt really make a new alternative magically available. Until that alternative men will continue to use finasteride despite the risks.

Well if they are informed that's what matters. Honestly if heroin regrew hair I think some men would use it... It's kinda a matter of perspective and priority. Hopefully sideless treaments come out soon

 

[washed_up]

Well if they are informed that's what matters. Honestly if heroin regrew hair I think some men would use it... It's kinda a matter of perspective and priority. Hopefully sideless treaments come out soon

How many drugs with no side effects have you ever heard of?

 

[Arrade]

How many drugs with no side effects have you ever heard of?

I said treatment. Everything in the Brotzu lotion is found naturally

 

[washed_up]

I said treatment. Everything in the Brotzu lotion is found naturally

If it comes out, I'm sure it will have side effects. Even a basic shampoo like Nizoral does.

 

[Btg]

If it comes out, I'm sure it will have side effects. Even a basic shampoo like Nizoral does.

well the purpose of p3074 is to inhibit scalp 5ars with minimal drug going systemic . I personally believe even a 30-40 % serum dht reduction is gonna be generally tolerated , considering oral finasteride eventually inhibits 70 % independent of the dosage (i guess the same amounts aplly to neurosteroids ) . All in all i dont expect it to be as good as oral finasteride , but if you can minimise or avoid side effects while at least slowing down hair loss effectively it is not half bad imo

 

[washed_up]

well the purpose of p3074 is to inhibit scalp 5ars with minimal drug going systemic . I personally believe even a 30-40 % serum dht reduction is gonna be generally tolerated , considering oral finasteride eventually inhibits 70 % independent of the dosage (i guess the same amounts aplly to neurosteroids ) . All in all i dont expect it to be as good as oral finasteride , but if you can minimise or avoid side effects while at least slowing down hair loss effectively it is not half bad imo

I think the most complete regimen is a combination of a mildly systemic approach while also targeting the scalp. I hope to see both this topical and seti/fevi used in conjunction and see how it stacks up.

 

[Btg]

I think the most complete regimen is a combination of a mildly systemic approach while also targeting the scalp. I hope to see both this topical and seti/fevi used in conjunction and see how it stacks up.

Seti , topical anti androgens like equol or cb who might have a good safety profile , and maybe growth factor injections + good ol minoxidil combined with topical finasteride might give a pretty good result without major serum hormone changes , even if sisheido tsuji follica all fail , i m confident in several years topicals will be enough for mild regrowth and maintainance

 

[XRobot]

when will be the study results published ?

 

[jamesbooker1975]

True, but again if finasteride caused cancer some men would still use it because its the only and best option available. Criticizing the one and only best treatment doesnt really make a new alternative magically available. Until that alternative men will continue to use finasteride despite the risks.

That is the problem, Think that Finasteride is the best available treatment. First at all, you don't have cancer.
Second, if you don't care about side effects, simple go with Dutasteride, that is much, much better than finasteride as you can see it with photos in the phase 2 GSK results of Dutasteride for male pattern baldness.

Second, again, DHT is the cause of male pattern baldness is a theory from the 70s !!!!!!! Did you even bother to read the Costarelis study on PDG2 and baldness ?
DHT is not elevated in balding scalps, meaning it simple active something on the follicle that finally activate the release of PDG2 that is much, much higher on balding scalp .
So why use Finasteride instead of Cetirizine ? Of course, Propecia have tons of propaganda since the last 21 years, while cetirizine not. Is cause that ? if so, you are missing the power of the internet and the oportunity to read 1000s or clinical studies.

Want a super combo that will be much, much better than finasteride ? MInoxidil 5%+ ketoconazole cream + cetirizine 1%

 

[ZenHead]

That is the problem, Think that Finasteride is the best available treatment. First at all, you don't have cancer.
Second, if you don't care about side effects, simple go with Dutasteride, that is much, much better than finasteride as you can see it with photos in the phase 2 GSK results of Dutasteride for male pattern baldness.

Second, again, DHT is the cause of male pattern baldness is a theory from the 70s !!!!!!! Did you even bother to read the Costarelis study on PDG2 and baldness ?
DHT is not elevated in balding scalps, meaning it simple active something on the follicle that finally activate the release of PDG2 that is much, much higher on balding scalp .
So why use Finasteride instead of Cetirizine ? Of course, Propecia have tons of propaganda since the last 21 years, while cetirizine not. Is cause that ? if so, you are missing the power of the internet and the oportunity to read 1000s or clinical studies.

Want a super combo that will be much, much better than finasteride ? MInoxidil 5%+ ketoconazole cream + cetirizine 1%

But tissue DHT actually is elevated in balding scalps...

 

[Johnt1997]

That is the problem, Think that Finasteride is the best available treatment. First at all, you don't have cancer.
Second, if you don't care about side effects, simple go with Dutasteride, that is much, much better than finasteride as you can see it with photos in the phase 2 GSK results of Dutasteride for male pattern baldness.

Second, again, DHT is the cause of male pattern baldness is a theory from the 70s !!!!!!! Did you even bother to read the Costarelis study on PDG2 and baldness ?
DHT is not elevated in balding scalps, meaning it simple active something on the follicle that finally activate the release of PDG2 that is much, much higher on balding scalp .
So why use Finasteride instead of Cetirizine ? Of course, Propecia have tons of propaganda since the last 21 years, while cetirizine not. Is cause that ? if so, you are missing the power of the internet and the oportunity to read 1000s or clinical studies.

Want a super combo that will be much, much better than finasteride ? MInoxidil 5%+ ketoconazole cream + cetirizine 1%

How does one get ahold of cetirizine, is it worth adding alongside finasteride? Is it expensive?

 

[Btg]

How does one get ahold of cetirizine, is it worth adding alongside finasteride? Is it expensive?

cetirizine can be found in antihistamines
there are mixed opinions about cetirizine effectiveness ,it is considered to be a pgd2 antagonist so it might help.
i personally would rather try setipiprant , but it is still too expensive for my standards

 

[abcdefg]

cetirizine can be found in antihistamines
there are mixed opinions about cetirizine effectiveness ,it is considered to be a pgd2 antagonist so it might help.
i personally would rather try setipiprant , but it is still too expensive for my standards

I dont know what you guys are talking about with PGD2. I have not seen a single study showing results from any pgd2 antagonist. Not any existing drug trials or a result of any kind showing or proving that pgd2 antagonists have any results for hair. A paper suggesting PGD 2 is implicated in male pattern baldness or elevated, and then showing that causes male pattern baldness directly are two different things. I have not seen proof.
When I see those studies, and the drug is available from a reliable source then we talk. Until that happens finasteride is king of the jungle. Link to me the 5 year double blind trial showing that pgd2 antagonist stops male pattern baldness?

 

[Btg]

I dont know what you guys are talking about with PGD2. I have not seen a single study showing results from any pgd2 antagonist. Not any existing drug trials or a result of any kind showing or proving that pgd2 antagonists have any results for hair. A paper suggesting PGD 2 is implicated in male pattern baldness or elevated, and then showing that causes male pattern baldness directly are two different things. I have not seen proof.
When I see those studies, and the drug is available from a reliable source then we talk. Until that happens finasteride is king of the jungle. Link to me the 5 year double blind trial showing that pgd2 antagonist stops male pattern baldness?

well if you take finasteride and dont get sides then you stick with finasteride , im pretty sure everyone here knows it is effective for hair loss

 

[Arrade]

I dont know what you guys are talking about with PGD2. I have not seen a single study showing results from any pgd2 antagonist. Not any existing drug trials or a result of any kind showing or proving that pgd2 antagonists have any results for hair. A paper suggesting PGD 2 is implicated in male pattern baldness or elevated, and then showing that causes male pattern baldness directly are two different things. I have not seen proof.
When I see those studies, and the drug is available from a reliable source then we talk. Until that happens finasteride is king of the jungle. Link to me the 5 year double blind trial showing that pgd2 antagonist stops male pattern baldness?

"Cetirizine a second generation anti-histaminic agent and more specifically an H1 receptor blocker has been observed to reduce PGD2 release from mast cells [71], whereas, increase the release of PGE2 in a concentration-dependent manner, from human monocytes in in vitro setting [72]." http://medcraveonline.com/MOJBB/MOJBB-03-00025.php

Photos inside:

 

[jamesbooker1975]

cetirizine can be found in antihistamines
there are mixed opinions about cetirizine effectiveness ,it is considered to be a pgd2 antagonist so it might help.
i personally would rather try setipiprant , but it is still too expensive for my standards

"Might help " did you read the paper with photos of 2017 ?
Setipiprant is "homemade " for now. While you can get oral drop to be use it as topical lotion at 1 % in most countries or online.

 

[jamesbooker1975]

I dont know what you guys are talking about with PGD2. I have not seen a single study showing results from any pgd2 antagonist. Not any existing drug trials or a result of any kind showing or proving that pgd2 antagonists have any results for hair. A paper suggesting PGD 2 is implicated in male pattern baldness or elevated, and then showing that causes male pattern baldness directly are two different things. I have not seen proof.
When I see those studies, and the drug is available from a reliable source then we talk. Until that happens finasteride is king of the jungle. Link to me the 5 year double blind trial showing that pgd2 antagonist stops male pattern baldness?

Jesus Christ , how many more times I have to post the same study of 2017 ? Where do you read about hair loss science ? on TMZ ? lol
https://www.ncbi.nlm.nih.gov/pubmed/28604133

Search for the whole paper.

You did not even read the paper of 2012 .
The paper show

. PDG2 is extremly elevated on male pattern baldness zone
. When they apply pdg2 to in vitro scalp, same model used to show that DHT inhibit hair, it inhibit hair
- When they apply pdg2 but they know down the CTRH2 receptor, hair grow again .

All that 3 things where demostrated on that great paper.

You really, really, really , need to READ. Instead of wasting our time posting over and over the same papers that you don't read.

 

[jamesbooker1975]

well if you take finasteride and dont get sides then you stick with finasteride , im pretty sure everyone here knows it is effective for hair loss

If you take finasteride and you don't have side effects, you might be a Mutant .

 

[Bitless]

If you take finasteride and you don't have side effects, you might be a Mutant .

Call me a mutant

 

[jonnywalker93]

Lol what inclusion criteria did I just read? "Willing to have a tattoo in target area"....wtf?