Alpha-ketoglutarate For Adipose Tissue Rejuvenation

[Squeegee 2.0]

In summary, through affecting histone and DNA demethylation, aKG is a critical mediator of cell differentiation and tissue homeostasis. While its level declines during aging, dietary supplementation of AKG increases intracellular aKG level, which can rejuvenate stem/progenitor cell function during aging, maintaining the health of adipose tissue. Because active DNA demethylation is required for the differentiation of progenitor cells in general, the dietary aKG intervention might prevent the senescence of other tissues due to aging as well.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425480/


Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026732/

 

[Squeegee 2.0]

 

[Squeegee 2.0]

Alpha-Ketoglutarate: Physiological Functions and Applications
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703346/

 

[John Difool]

Your copy pasting of links is cool and all that but you never take the time to write feedback related to hair loss. Would you mind doing so?

 

[Squeegee 2.0]

Your copy pasting of links is cool and all that but you never take the time to write feedback related to hair loss. Would you mind doing so?

I know! I will Johnny! I am super busy lately!

It seems that the Krebs cycle is the answer to a lot of things like Autophagy, aging and health span.

 

[John Difool]

No worries mate. I just think it would be useful to provide some application guidance for folks like myself with no clue on how to translate dosages in vitro or on rats to in vivo on human scalp. Last I read was AKG 5g daily oral or 5mg topical.

 

[Squeegee 2.0]

It seems that AKG stimulates Stem/progenitor cells production. The loss of progenitor cells / addition of senescent cells is the main problem in Androgenetic Alopecia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026732/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293868/

But here comes AKG which is a part of the Krebs cycle cascade dealing with both issues.

Stem/progenitor cells generate new cells to replace senescent cells and maintain tissue homeostasis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425480/#:~:text=The aKG deficiency in stem,is worsened due to aging.&text=The aKG deficiency associated with,and tissue homeostasis during aging.

Therapeutic Potential of Stem Cells in Follicle Regeneration
https://www.hindawi.com/journals/sci/2018/1049641/#copyright

 

[Squeegee 2.0]

It rejuvenates the adipose tissue which is primordial to hair cycle:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507425/
https://www.sciencedirect.com/science/article/pii/S0022202X17330919

 

[sonictemples]

It rejuvenates the adipose tissue which is primordial to hair cycle:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507425/
https://www.sciencedirect.com/science/article/pii/S0022202X17330919

Hello Squeegee, would you be kind enough to give us a little glimpse of what you use on a regular basis to prevent or even reverse androgen-related miniaturization of hair? You seem to share a lot of different concepts which made me wonder how do you apply those to your own treatments for thinning haar. Thank you.

 

[Squeegee 2.0]

L-Glutamine is a precursor of AKG

The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications

https://pubmed.ncbi.nlm.nih.gov/27161106/

 

[John Difool]

So how much of l-glutamine oral do you take?

 

[Poppyburner]

April 26th, 2011:

'Meanwhile, L'Oreal's luxury Redken brand has launched a spray-on treatment, Intra Force, containing aminexil, which is thought to prevent the build-up of collagen around follicles. "During the hair cycle the follicle has to be rebuilt from stem cells," explains Dr Bruno Bernard, director of research for life sciences at L'Oreal. "Stem cells in human hair follicles are localised in two different reservoirs - one is in the upper part of the follicle and the other in the lower part.

"The cells in the lower part are required to activate the cells in the upper part and so help to maintain the follicle function. The thickening of collagen in the connective tissue sheath, which sits around the base of the hair follicle, prevents the movement of stem cells from the lower reservoir to the upper reservoir. Bit by bit, the follicle is squeezed and causes the follicles to grow smaller and smaller." Indeed, research from The Rockefeller University in New York suggests movement between the two groups of stem cells is crucial in normal hair growth.

Another recent study, at the University of Pennsylvania, has shown that bald areas of scalp contain the same number of stem cells as hairy areas. It disproved theories that hair loss in androgenic alopecia was due to a loss of follicle stem cells suggesting that they have just become inactive.

This has raised hopes that it may be possible to regenerate follicles by reactivating these stem cells. "There may be a lack of an activator or the presence of an inhibitor," says Dr George Cotsarelis, chairman of the department of dermatology at the University of Pennsylvania. "We are looking to tackle this mostly by activating genetic pathways we think are important either through transgenic approaches or pharmacologically. It's reasonable to believe that a therapy based on manipulating stem cells will eventually be available."'

https://www.watoday.com.au/lifestyle/the-bald-truth-is-not-so-bad-20110426-1duhx.html

 

[TurboFixer]

@Squeegee 2.0 Thanks for all these posts man. I just wish I had a better grasp on the application.

Also like, @sonictemples, I'd love to learn about how you are applying these findings personally!

 

[Squeegee 2.0]

Guys! I don't give advice anymore on hairloss treatments. It stirs way too much drama. There is a lot of haters/ b****s on this forum.

Personally right now, I am micro needling every 2 weeks with blood pissing out. No Minoxidil, No finasteride.

I am taking supplements. I bought individual supplements seen in Nuchido

https://nuchido.com/

I will also dramatically optimize Krebs cycle with supplements. It seems that Coenzyme A, AKG and Oxaloacetate when optimized contributes to healthspan , autophagy and proper homeostasis.

Coenzyme A : Pantethine + L-Cysteine with meal
AKG : L-Glutamine Alpha Ketoglutarate or L-Arginine alpha ketoglutarate .. with meal because that sh*t is super expensive : https://rejuvant.com/
Oxaloacetate : Malic Acid with meal .Cheap and precursor of Oxaloacetate.

 

[Squeegee 2.0]

People on this forum need to understand that Androgenetic Alopecia is associated with prostate cancer, cardiovascular diseases, hypertension, metabolic syndrome, insulin resistance etc.. . We need to fight oxidative stress, inflammation and overreactive AR all across the damn body.

 

[Poppyburner]

'One of the oldest explanations for baldness in the Western world was the "exhaustion of nervous energy"—that is, the health and capability of the nervous system. In the 1881 book, American Nervousness, George W. Beard[sic] explains that baldness and many other problems increase at the expense of nervous energy due to the stress and strain of modern life:

"The increasing popularity of baldness is one of the minor but most instructive expressions of nerve sensitiveness. Among savages in all parts of the earth baldness is unusual, except in extreme age, and gray hairs come much later than with us. So common is male baldness in our large cities that what was once a deformity and exception is now almost the rule, and an element of beauty. One may be bald without being very nervous; but the general prevalence of baldness comes from the general prevalence of nervousness." —George M. Beard (1881)
George Beard called the exhaustion of nervous energy "neurasthenia" and in many ways, the theory was the intellectual stepchild to Hans Selye's 1936 work on metabolic stress. In Beard's view, the person's unfavorable environment caused pattern baldness.

Complementing Beard's environmental view of hair loss was the observation that baldness was noted less often among those engaged in manual labor and more frequently among scientists, academics, ministers, lawyers, and legislators. To advocates of the time, this suggested that simple livin' was hair protective and that "brainy types" were more likely to go bald.'

https://www.dannyroddy.com/weblog/mysteriousconductorhaircycleclock



November 10th, 2017:

'Researchers found that people who exercised well over the national physical activity guidelines for many years were more likely to develop coronary artery calcification (CAC) by middle age.

CAC, which is measured using CT scans, indicates that calcium-containing plaques are present in the arteries of the heart — a predictor of heart disease.

The study included almost 3,200 people. Researchers followed them for 25 years, starting when they were young adults.

At the beginning of the study, and during three to eight follow-up visits, participants reported how often and the types of physical activities they participated in.

Researchers used this information to divide participants into three groups: those who met the physical activity guidelines, those who fell below, and those who exceeded it by at least three times.

The U.S. Department of Health and Human Services’ “2008 Physical Activity Guidelines for AmericansTrusted Source” recommend that adults do at least 150 minutes a week of moderate-intensity, or 75 minutes a week of vigorous-intensity, aerobic activity.

Vigorous-intensity activities include running, biking, swimming, exercise or dance classes, and strenuous sports.

Moderate-intensity activities include walking, hiking, golfing, home exercises, and gardening.

People who exercised three times the recommended amount — or the equivalent of 450 minutes a week of moderate activity — had a 27 percent higher risk of developing CAC during the study period, compared to those who exercised the least.

The effects of extreme exercise were even greater for white participants.

This group had an 80 percent higher risk of developing CAC. The risk was slightly higher for white men than white women.

Statistically, though, the results based on race and gender were only significant for white men. This is probably because the other groups had too few participants.

The study also reinforced the benefits of regularly meeting the physical activity guidelines.

People who exercised less than the recommended amounts were more likely to have high blood pressure and type 2 diabetes in middle age.'

https://www.healthline.com/health-n...lth-problems#Extreme-exercise-may-carry-risks

 

[sonictemples]

'One of the oldest explanations for baldness in the Western world was the "exhaustion of nervous energy"—that is, the health and capability of the nervous system. In the 1881 book, American Nervousness, George W. Beard[sic] explains that baldness and many other problems increase at the expense of nervous energy due to the stress and strain of modern life:

"The increasing popularity of baldness is one of the minor but most instructive expressions of nerve sensitiveness. Among savages in all parts of the earth baldness is unusual, except in extreme age, and gray hairs come much later than with us. So common is male baldness in our large cities that what was once a deformity and exception is now almost the rule, and an element of beauty. One may be bald without being very nervous; but the general prevalence of baldness comes from the general prevalence of nervousness." —George M. Beard (1881)
George Beard called the exhaustion of nervous energy "neurasthenia" and in many ways, the theory was the intellectual stepchild to Hans Selye's 1936 work on metabolic stress. In Beard's view, the person's unfavorable environment caused pattern baldness.

Complementing Beard's environmental view of hair loss was the observation that baldness was noted less often among those engaged in manual labor and more frequently among scientists, academics, ministers, lawyers, and legislators. To advocates of the time, this suggested that simple livin' was hair protective and that "brainy types" were more likely to go bald.'

https://www.dannyroddy.com/weblog/mysteriousconductorhaircycleclock

Ah yes 200 year old science

 

[Armando Jose]

The cells in the lower part are required to activate the cells in the upper part and so help to maintain the follicle function.

movement between the two groups of stem cells is crucial in normal hair growth.

Very interesting point and it is in the line of my idea where hardened sebum inside pilosebaceous unit is a key in this "movement". Hair shaft acts as a wick to move/eliminate sebum produced in the SG, larger hairs are more effcient in this task, then people (usually women) with long hair are less prone to develope common hair loss.

One of the oldest explanations for baldness in the Western world was the "exhaustion of nervous energy"

In the ancient Greece, yes.

 

[Armando Jose]

Ah yes 200 year old science

Clearly common baldness is not a recent issue and seem that we know moreless the same about it in centuries.

 

[Poppyburner]

Very interesting point and it is in the line of my idea where hardened sebum inside pilosebaceous unit is a key in this "movement". Hair shaft acts as a wick to move/eliminate sebum produced in the SG, larger hairs are more effcient in this task, then people (usually women) with long hair are less prone to develope common hair loss.

'The arrector pili muscles are small muscles attached to hair follicles in mammals. Contraction of these muscles causes the hairs to stand on end,[1] known colloquially as goose bumps. [...]
Pressure exerted by the muscle may cause sebum to be forced along the hair follicle towards the surface, protecting the hair.'

https://en.wikipedia.org/wiki/Arrector_pili_muscle


'Conclusions: APM [arrector pilli muscle] degeneration and replacement with fat in Androgenetic Alopecia has not previously been described. The underlying mechanism remains to be determined. However, we speculate that this phenomenon might be related to depletion of stem or progenitor cells from the follicle mesenchyme, explaining why Androgenetic Alopecia is treatment resistant.'

https://pubmed.ncbi.nlm.nih.gov/24579818/#:~:text=Background: Androgenic alopecia (Androgenetic Alopecia),certain degree of follicular regression.&text=The arrector pili muscle (APM,follicle to the surrounding skin.