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I think progesterone and other progestins‘ benefit may lie in the PPARγ agonist effect of activating the progesterone receptor.Life-flo has a piddly amount of estriol in it, I'd need to use almost an entire container each day. Plus there's the absorption problems that ephemeral-kitten mentioned. It would be better to use something in a vehicle that contains alcohol or DMSO.
And as for progesterone, there's different effects of different routes of administration. large doses have antigonaotropin effects, especially when taken rectally. Progesterone is also useful for breast development in late tanner stages. But I'm more interested in using it in smaller topical doses. This has been experimentally shown to improve skin and hair health, though truthfully I'm not sure what the biochemical mechanism here at play is
Here is an interesting article about progestogens' effects on PPARγ and CD36:
https://www.jbc.org/content/291/29/15108.full.pdf
This is good reading on the subject of PPAR mediated hair and adipose effects:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399744/
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