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I’m gonna stick with Castor and Niacin. I don’t wanna f*** stuff up too much. I love the niacin flush tho. Dunno if it’s a coincidence, but I feel like my shedding is WAY down since incorporating it
Topical Cetirizine Is Still Worth A Try ?
- Thread starter Vinc2097
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What's your dosage for niacin?
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1000 mg
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Do you suppose a systemic PGD2 reduction is required to achieve any effect? Cetirizine would seem to suggest it is not so.
Would aspirin work topically to any extent?
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It's very hard to dissolve aspirin for topical application apparently
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Thanks
There are some people who noticed this effect from niacin in the past. Too bad we don't know much, not a lot of people take it for male pattern baldness nowadays
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I've no doubt that Niacin is helpful as long as you tolerate it. I could deal with the flush, but it's serotonergic effects are noticeable. I don't like anything that breaks my 'zen', so to speak, and I feel noticeably irritable/aggressive after using it and it carries on in to the next day.
I might mess around with it more to see if I can find a sweet spot with it, maybe.
I've thought about topical aspirin but haven't looked into it much to know whether or not it dissolves well, vehicle, etc.
Not sure what you're getting at with the ceti comment. Anything you put on your skin is going systemic to some degree. Aspirin is probably the closest OTC drug we have to dealing with PGD2 without negatively affecting hormones or neurotransmitters.
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There are aspirin-based shampoos.
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thedoubter
Member
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How does niacin influence serotonin?
I’ve just begun taking Luteolin - apparently this reduces PGD2, so I can avoid the Aspirin route. Would I need to take Niacin as well - I don’t like the thought of this messing with neurotransmitters mind?
I now need a PGE2 activator in my Arsenal - Castor Oil topically 2/3 times a week in the hairline and crown, would this be enough - and dermarolled to help absoroption
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Excess nicotinamide increases plasma serotonin and histamine levels - PubMed
Methylation, a methyl group-consuming reaction, plays a key role in the degradation (i.e., inactivation) of monoamine neurotransmitters, including catecholamines, serotonin and histamine. Without labile methyl groups, the methylation-mediated degradation cannot take place. Although high niacin...
pubmed.ncbi.nlm.nih.gov
Nitric oxide is produced via 5-HT1B and 5-HT2B receptor activation in human coronary artery endothelial cells - PubMed
The aim of this study is to clarify the serotonin (5-hair transplant) receptor subtypes responsible for 5-hair transplant-induced nitric oxide (NO) production in cultured human coronary artery endothelial cells (HCAECs). Reverse transcription-polymerase chain reactions revealed that HCAECs possessed only 5-HT1B and...
pubmed.ncbi.nlm.nih.gov
(PDF) Niacin-induced "Flush" Involves Release of Prostaglandin D-2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model
PDF | Niacin lowers serum cholesterol, low-density lipoprotein, and triglycerides, and it raises high-density lipoprotein. However, most patients... | Find, read and cite all the research you need on ResearchGate
www.researchgate.net
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I bet in 50 years, our kids will look back and think we were nuts for all this sh*t we do to keep our hair.Excess nicotinamide increases plasma serotonin and histamine levels - PubMed
Methylation, a methyl group-consuming reaction, plays a key role in the degradation (i.e., inactivation) of monoamine neurotransmitters, including catecholamines, serotonin and histamine. Without labile methyl groups, the methylation-mediated degradation cannot take place. Although high niacin...pubmed.ncbi.nlm.nih.gov
Nitric oxide is produced via 5-HT1B and 5-HT2B receptor activation in human coronary artery endothelial cells - PubMed
The aim of this study is to clarify the serotonin (5-hair transplant) receptor subtypes responsible for 5-hair transplant-induced nitric oxide (NO) production in cultured human coronary artery endothelial cells (HCAECs). Reverse transcription-polymerase chain reactions revealed that HCAECs possessed only 5-HT1B and...pubmed.ncbi.nlm.nih.gov
(PDF) Niacin-induced "Flush" Involves Release of Prostaglandin D-2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model
PDF | Niacin lowers serum cholesterol, low-density lipoprotein, and triglycerides, and it raises high-density lipoprotein. However, most patients... | Find, read and cite all the research you need on ResearchGatewww.researchgate.net
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Who gives a f*** what they will think - they will probably be eternal fullheads so they will never understand.
Oh and actually - unless I solve this hair loss sh*t they probably won't even exist, so f*** 'em
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This is post-industrial society and with us at peace, the U.S., I mean, males aren't necessary any longer. You guys aren't MtF's but there is a calming aspect to being chemically female that many find really pleasant. When males are needed, it is always them doing the shitty work like lumberjack, steel worker, coal miner, stevedore, farmer, i.e. back-breaking work.
I still mostly think of myself as male though so it is an interesting dynamic. Half the time, I forget that I changed my name and I still use male pronouns but now I used them randomly so sometimes I use she and at times, they. The thing is that I ended up liking this so I don't know. I just don't know whether I only did this for the hair.
As to the baldness treatment debate, as soon as I put the wig on, I started get attention and I started making friends more easily and Covid19 ruined all of that. In my male person, still bald for months from the shed, I sometimes got treated like crap eh but romantically, women seemed to groove on the dress and now I have to decide if I am just going to keep going back and forth or pick a persona because it doesn't matter to me. I have noticed with my hair improvement that I never get clocked but it is probably more so my carrying around a pair of D-cups that I simply cannot hide any longer. They have gotten too large. So, everybody be careful what you wish for cause nothing in life is free.
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Hi, sadly it seems Aspirin is anti androgenic too.. I have noticed a lack of sexual interest since starting high dose aspirin. I don't know if it's related but look at this studyMight actually drop down to PGE2+Aspirin myself, it's the only one out of the 3 PGD2 OTC options we have that I don't know of any potential antiandrogenic effects.
Could be placebo, but I've felt low androgen symptoms some days that lead me to think that the Ceti had gone systemic. Unfortunately, some histamine receptors are beneficial for testosterone and dopamine.
Potential negative effects of anti-histamines on male reproductive function - PubMed
Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. The literature on the role of HA within the male gonad has expanded over the last years, attracting attention to potential unexpected side-effects of anti-histamines...pubmed.ncbi.nlm.nih.gov
Seems like everything that shows promise effects androgens whether directly or indirectly. Bleh.
Effect of graded doses of acetylsalicylic acid on sperm chromatin integrity and maturity of germinal epithelium in adult male mouse Mahmoudi-Lafout F, Mohammadghasemi F - Asian Pac J Reprod
Asian Pacific Journal of Reproduction, Hainan Medical University
www.apjr.net
"ASA reduced sperm count and movement maybe due to a decrease in androgen level. In this study, serum testosterone was decreased. Epididymis is the main site of sperm maturation and is an organ that is completely androgen dependent. Obviously, in episodes of decreased testosterone, the function of epithelium of epididymis is altered, which may also be due to the toxic effects of aspirin on epithelial cells
In conclusion, results of the present study showed that administration of ASA over the 14 days in dose of 5.00 mg increases sperm DNA fragmentation index and therefore reduces DNA integrity and in doses of 0.50, 1.00, 5.00 mg reduces serum testosterone level without having effect on LH. Generally ASA has deleterious effects on the male reproductive indices even in low doses."
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Yeah, I saw your post over at RPF. Until I see data or a convincing enough rebuttal to it, I probably won't use it anymore myself. Thankfully, it was only a few days I did use it. The lack of sexual interest could've been down to it supposedly being anti-estrogen, but who knows.
Anyway, I have OC000459 on the way for dealing with PGD2. Hopefully any side effects are tolerable.
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Did some more reading on aspirin, and it seems that in the short-term it tends to be beneficial, whereas long-term it seems like it can go either way in terms of it's effects on androgens.
While reading more about aspirin, I stumbled upon this:
Which seems to imply that administration of PGE1 and PGE2 has a negative effect on spermatogenesis. So, seemingly everything at this point has a direct or indirect effect on androgens or general well-being in varying degrees and you really just have to weigh your options and gauge how you respond to each treatment.
Anyway, I have OC000459 on the way for dealing with PGD2. Hopefully any side effects are tolerable.
-edit-
Did some more reading on aspirin, and it seems that in the short-term it tends to be beneficial, whereas long-term it seems like it can go either way in terms of it's effects on androgens.
While reading more about aspirin, I stumbled upon this:
The effect of prostaglandins and prostaglandin inhibitors on spermatogenesis - PubMed
The effect of the prostaglandin inhibitors, aspirin and indomethacin and of prostaglandins PGE1 and PGE2 on spermatogenesis in the mature male mouse has been studied. Aspirin at 100 mg/kg and at 200 mg/kg, and indomethacin at 1.0 mg/kg given orally twice a day for fifteen days produced a marked...
pubmed.ncbi.nlm.nih.gov
Which seems to imply that administration of PGE1 and PGE2 has a negative effect on spermatogenesis. So, seemingly everything at this point has a direct or indirect effect on androgens or general well-being in varying degrees and you really just have to weigh your options and gauge how you respond to each treatment.
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Thank you for the pge effects on testisYeah, I saw your post over at RPF. Until I see data or a convincing enough rebuttal to it, I probably won't use it anymore myself. Thankfully, it was only a few days I did use it. The lack of sexual interest could've been down to it supposedly being anti-estrogen, but who knows.
Anyway, I have OC000459 on the way for dealing with PGD2. Hopefully any side effects are tolerable.
-edit-
Did some more reading on aspirin, and it seems that in the short-term it tends to be beneficial, whereas long-term it seems like it can go either way in terms of it's effects on androgens.
While reading more about aspirin, I stumbled upon this:
The effect of prostaglandins and prostaglandin inhibitors on spermatogenesis - PubMed
The effect of the prostaglandin inhibitors, aspirin and indomethacin and of prostaglandins PGE1 and PGE2 on spermatogenesis in the mature male mouse has been studied. Aspirin at 100 mg/kg and at 200 mg/kg, and indomethacin at 1.0 mg/kg given orally twice a day for fifteen days produced a marked...pubmed.ncbi.nlm.nih.gov
Which seems to imply that administration of PGE1 and PGE2 has a negative effect on spermatogenesis. So, seemingly everything at this point has a direct or indirect effect on androgens or general well-being in varying degrees and you really just have to weigh your options and gauge how you respond to each treatment.
pubmed.ncbi.nlm.nih.gov/2591605
This study shows that pgd2 has a negative impact on testosterone production too, so if pge2/pge1 and pgd2 have an negative impact on testosterone production /Leydig cells, then we know the possible negative impact of aspirin on testosterone doesn't come from COX2 inhibition.
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I'll need to look into it more, but I've seen some studies that imply PGD2 stimulates testosterone production.
"Production of PGD2 was indeed proven in freshly isolated hamster Leydig cells (2), which also respond to PGD2 by increased testosterone production."
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Interesting study, thank you
Everything working against male pattern baldness seems to destroy androgens levels. Like i said on RPF, it's always a trade between our hair or our balls. So tired
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It probably improves scalp health by decreasing or keeping histamine decreased. In telogen effluvium it has been said that their is more histamine than normal. Maybe it reduces pgd2 to some extent. Is there really any other pgd2 inhibitors out there that are more affordable or easy to just pick up at the store? fluocinolone acetonide increases collagen type 2, is also an ant inflammatory, and has been used in .2% amounts successfully for alopecia areata.