Gadgetine

Group Buy: ARV-110 PROTAC+ WAY-200070 ERb Agonist

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Johnson40

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Honestly lads, if you're using SMI+ a Wnt agonist + Minoxidil ( So potentially another wnt agonist ) + A 5ar inhibitor + WAY + Some anti inflammatory stuff like ket shampoo.
What's left for you to regrow? You're targeting every known area of hair loss, unless you're an 80 yo with a NW7 i fail to see how you guys still have much to gain from that.

I'd expect at least a complete regrowth with that cocktail. Unless the calcification and aerector pili preventing regrowth proved to be true.
 
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Jakejr

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Rob English. perfect hair guy has a big article on this topic. Mentions gut may regulate DHT somehow. Seems he think skipping carbohydrates & eating carnivore diet is good for hair.
 
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jan_miezda

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Johnson40 said:
Honestly lads, if you're using SMI+ a Wnt agonist + Minoxidil ( So potentially another wnt agonist ) + A 5ar inhibitor + WAY + Some anti inflammatory stuff like ket shampoo.
What's left for you to regrow? You're targeting every known area of hair loss, unless you're an 80 yo with a NW7 i fail to see how you guys still have much to gain from that.

I'd expect at least a complete regrowth with that cocktail. Unless the calcification and aerector pili preventing regrowth proved to be true.
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And don’t forget micro needling
 
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hairlossisevil

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Jakejr said:
Rob English. perfect hair guy has a big article on this topic. Mentions gut may regulate DHT somehow. Seems he think skipping carbohydrates & eating carnivore diet is good for hair.
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We'll he's an idiot. Gut microflora does have effect on immune system though. That's why (fecal matter transplant) it was effective for AA and is effective for many other autoimmune disorders. So no, exclusively eating dead animals won't regrow your hair. There is no diet that will prevent stop or reverse Androgenetic Alopecia.
 
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mtx29

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pegasus2 said:
We are organizing a group buy now for a PROTAC androgen receptor degrader and a highly selective estrogen receptor beta agonist. Everyone is welcome to join. The combination of these two compounds should give hair regrowth comparable to traditional mtf regimens but without the sexual side effects. I will start with a brief overview of how each of these compounds work.

ARV-110 is a potent PROTAC. It recruits the AR (androgen receptor) to the E3 ubiquitan ligase promting its degradation so that DHT cannot bind to it. This is temporary because new receptors are generated, but until that happens it eliminates AR activation. This is the first step that's required to treat hair loss. Kintor is currently developing a similar PROTAC to treat Androgenetic Alopecia, and they expect it to have no side effects.

WAY-200070 is a potent and selective ERβ (estrogen receptor beta ) agonist. It binds to ERβ without binding to ERα (estrogen receptor alpha) except at very high doses. This is perfect for us because ERβ is believed to mediate 17β-estradiol-induced hair growth, and does not have any feminizing effects. Things like breast growth and fat distribution etc., are believed to be controlled by ERα. ERβ activation actually silences ERα so it is expected to have the opposite effect and actually reduce or inhibit gyno while still promoting hair growth.

We have seen tremendous hair regrowth, and in some cases complete reversal of hair loss in male to female transgenders who use potent AR antagonists combined with 17β-estradiol. CIS men can't do that of course because the side effects are unacceptable. These two new compounds are available to us now and should allow us to reproduce the hair growth results of such feminizing treatments without the feminization aspect. Here are some of the examples of hair growth from using estrogen and potent AR antagonists, and what type of regrowth is expected from the combination of these two compounds at the proper dose.

View attachment 169266View attachment 169265View attachment 169264View attachment 169263View attachment 169262View attachment 169261

WAY-200070 is already being used by a handful of people on discord and they are reporting new vellus hairs in their temples. The people currently trialing are using concentrations between .1-.5% and applying it once to twice daily. The only side effects noted so far are hives/rash at the site of application in some and better skin generally. Now we are ordering more WAY-200070, and getting ARV-110 to go with it for the perfect combination. ARV-110 is being developed for castration resistant prostate cancer. The oral dose is 280-420mg daily, and almost totally suppresses the AR systemically at that dose. We will use just a small fraction of that dose topically. No one can guarantee what dose is safe and effective for either of these compounds, but most of us on discord are planning to use ARV-110 at .1% once a week. It has a 110 hour half-life so daily dosing is unnecessary. That's just 1mg/ml, or approximately 1/2000th of the oral dose for prostate cancer. Oral bioavailability is estimated at 25%. We estimate that only 5% of the topical dose will be absorbed systemically. That would give a systemic concentration that is 1/10,000th the concentration used in trials to shutdown the AR. This dose should not give any side effects. Personally I plan to use it daily so that I can just mix it together with WAY-200070. I will still use a concentration of .05-.1%, so I will be using more than others, about 7-14mg per week. Even this dose will give a systemic concentration that is around 1/700th that required to silence the AR systemically. One mg or less is impossible for most people to measure, so a stock solution may be required if you're using smaller and infrequent doses.

Here I will post further information on both compounds. ARV-110 has a large molecular weight of 812 Daltons so DMSO or microneedling will be required for topical absorption, but the large weight also helps to limit systemic absorption. At an oral dose of 35mg daily no adverse events were reported.

ARV-110 Phase 1/2 Dose Escalation: Interim Update

View attachment 169272


WAY-200070 is 67-fold more selective for ERβ over ERα. Erteberal has been trialed in humans for schizoprhenia at up to 150mg orally, and no sexual side effects were noted, leaving them to conclude that the doses used do not activate ERα. Since it's about 10x less potent there should be no activation of ERα at 15mg daily doses of WAY-200070. I am currently using this dose.

View attachment 169273

Price:
WAY-200070 is $130/g. Must order in increments of 1g.
ARV-110 is $130/200mg. Must order in increments of 200mg.
Shipping is $55 with a reship policy if your order is not received.

If you would like to participate in this group buy let us know here.
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Hi pegasus, I appreciate all your hard work on this and would like to participate in this as I am looking to maintain and regrow my hair! Could I also get an invite to the discord please?
 
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BaldLion

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Hello, thanks again to Pegasus for sharing some precious finding like this with us.
I am very interested to buy those products, can someone invite me in the discord group buy please?
i would be very grateful
 
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Nomiea7

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I'm interested as well, I want to follow up on this regimen. Typically how long do results show? I know the group buy is closed but can I get access to the discord?
 
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Jakejr

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Minoxidil when applied topically doesn’t gets to the follicles 100%. I just heard a transplant doctor say minoxidil w) propylene glycol absorbs at 1.4%. That means 98.6% just evaporates away. Also the strength of the sulfotransferase enzyme in an individual’s scalp may lessen the 1.4% number further.
This is one reason to microneedle
 
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scientist_0005

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Jakejr said:
Minoxidil when applied topically doesn’t gets to the follicles 100%. I just heard a transplant doctor say minoxidil w) propylene glycol absorbs at 1.4%. That means 98.6% just evaporates away. Also the strength of the sulfotransferase enzyme in an individual’s scalp may lessen the 1.4% number further.
This is one reason to microneedle
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i just think like, finasteride does go systemic, many drugs do, what insures this does not? and an AR degrader does not just reduce the action of dht, which some men can get away with, it makes it imoossible for any androgenic activity in that cell. so if it goes systemic in large enoufh quantities this is a problem much more than finasteride bc it also affevts action of free T. this was never trialed and tested on animals unlike what kintor is doing, they are testing the rate of absorption to figure out how mucb of it hits the blood stream. does it become inactive once it hits like CB? you realize activity of a given AR could be supressed for weeks? im not sure about this. but i am glad people are trying it, itd just inquire more information on it
 
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scientist_0005

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5minutesbeforemiracle said:
OP post explains their reasoning...
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but it is just assumptions. that is whx usually many clinical trials are required. and people still think finasteride is not understood even though it is an extremely well researched drug there is anlot of anti finasteride propaganda still despite that. ok so people assume 1/10000th of the csncer dosage foes systemic however if you incorporate micro needling and you needle into the lower dermis it might hit the blood stream directly making it quite unpreductable? and thats ignoring the fact thag nobody knows whether it will just stick around in the local tissue. i get that there us reason to be hopeful because if kintor for example would not expect these properties they would not initiate clinical trials, if it hadnt shown minimal absorption in animal tests, they again would not hsve inititiated human trials. thats good. but this is a different drug? it might behave very different. and805 daltons is quite a lot, it might just not penetrate at all or eith needling too much
 
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EMILIO CHESSA

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scientist_0005 said:
but it is just assumptions. that is whx usually many clinical trials are required. and people still think finasteride is not understood even though it is an extremely well researched drug there is anlot of anti finasteride propaganda still despite that. ok so people assume 1/10000th of the csncer dosage foes systemic however if you incorporate micro needling and you needle into the lower dermis it might hit the blood stream directly making it quite unpreductable? and thats ignoring the fact thag nobody knows whether it will just stick around in the local tissue. i get that there us reason to be hopeful because if kintor for example would not expect these properties they would not initiate clinical trials, if it hadnt shown minimal absorption in animal tests, they again would not hsve inititiated human trials. thats good. but this is a different drug? it might behave very different. and805 daltons is quite a lot, it might just not penetrate at all or eith needling too much
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but why don't you disappear JANEY stupid woman .... write a thousand lines to say what? nothing ... because before saying your bullshit you do not look at the posts !!
 
LouisSarkozy

LouisSarkozy

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Jakejr said:
Minoxidil when applied topically doesn’t gets to the follicles 100%. I just heard a transplant doctor say minoxidil w) propylene glycol absorbs at 1.4%. That means 98.6% just evaporates away. Also the strength of the sulfotransferase enzyme in an individual’s scalp may lessen the 1.4% number further.
This is one reason to microneedle
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man could you tell me the name of the Doctor who threw the 1.4% number i'm researching to compare the sytemic absoption of massive dose of topical vs oral and most Doctor are clueless. a leading trichologist in pain ( who conduct oral minoxidil studies) told me that 10ml of topical 5% eaqal 2.5/3 mg of oral but if absorption is 1.4% doesn't work
 
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Redgate

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scientist_0005 said:
but it is just assumptions. that is whx usually many clinical trials are required. and people still think finasteride is not understood even though it is an extremely well researched drug there is anlot of anti finasteride propaganda still despite that. ok so people assume 1/10000th of the csncer dosage foes systemic however if you incorporate micro needling and you needle into the lower dermis it might hit the blood stream directly making it quite unpreductable? and thats ignoring the fact thag nobody knows whether it will just stick around in the local tissue. i get that there us reason to be hopeful because if kintor for example would not expect these properties they would not initiate clinical trials, if it hadnt shown minimal absorption in animal tests, they again would not hsve inititiated human trials. thats good. but this is a different drug? it might behave very different. and805 daltons is quite a lot, it might just not penetrate at all or eith needling too much
Click to expand...
So what if it goes systemic? You're applying 1mg topically, and 40mg oral had no side effects in the trials. Yes of course it's assumptions, what did you expect? For people to pull the secret hair loss ARV trials out of their a.s.s?
 
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