Gadgetine

Exploring The Hormonal Route. Hair=life.

sg2000

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i think hrt can prevent Androgenetic Alopecia . if not we are all stupid here keep taking sh*t and still going bald(still miniaturizing).I really doubt you can still have significant loss after 10 yrs of hrt
 

BRezende

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i think hrt can prevent Androgenetic Alopecia . if not we are all stupid here keep taking sh*t and still going bald(still miniaturizing).I really doubt you can still have significant loss after 10 yrs of hrt
Is not just us, womens also go bald even with high estradiol levels in blood. Theres something more. Funny sh*t is womans go bald in diffuse pathern, same as me and as a lot people who dont responde to normal treatments.
 

SavingMyHair

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i think hrt can prevent Androgenetic Alopecia . if not we are all stupid here keep taking sh*t and still going bald(still miniaturizing).I really doubt you can still have significant loss after 10 yrs of hrt
I still think you can. Receptors on young people are so mutated than even minimal androgen signal will make us bald
 

SavingMyHair

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tbh the best solution would be an oral androgen receptor degrador and not abiraterone or corticosteroids that also affect adrenal glands. You kill your f*****g androgen receptors you are saved cause androgen would be on serum but wouldnt be able to do its job on tissues, as simple as that
 

BRezende

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tbh the best solution would be an oral androgen receptor degrador and not abiraterone or corticosteroids that also affect adrenal glands. You kill your f*****g androgen receptors you are saved cause androgen would be on serum but wouldnt be able to do its job on tissues, as simple as that
yeah tbh i also dont think is a long term solution.. but what the f*** can i try more? its really frustating try everything and still losing hair.

i have all those fuzzies hair on the temples that bridge and other responnders have but i dunno if im going to see actual thickening tbh
Thats a good sign, you should stick with your regimen.
 

SavingMyHair

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i have all those fuzzies hair on the temples that bridge and other responnders have but i dunno if im going to see actual thickening tbh
I got those hairs for 2+ years. They never got thicker just ugly and sparse. I have seen many people with that kind of regrowth on hairline. TBH to get a real hairline restoration u will have to get a transplant. The issue in most of us is the diffuse thinning that a transplant cant fix.
 

SavingMyHair

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yeah tbh i also dont think is a long term solution.. but what the f*** can i try more? its really frustating try everything and still losing hair.
There is no solution for ppl that suffer Androgenetic Alopecia from a young age. If you start balding between age 16-25 you are done there will be no fix for us, just try to maintain till genetic want us to go fully bald, cause the best joke here is the more you age the more sensitive your androgen receptors get so imagine if you have very sensitive receptor at age 16-25, just wait till you are 35-40
 

sg2000

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There is no solution for ppl that suffer Androgenetic Alopecia from a young age. If you start balding between age 16-25 you are done there will be no fix for us, just try to maintain till genetic want us to go fully bald, cause the best joke here is the more you age the more sensitive your androgen receptors get so imagine if you have very sensitive receptor at age 16-25, just wait till you are 35-40
show your hair
 

SavingMyHair

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IMO, androgen degrador wont help the majority of people who already tried HRT. If you're a young balder, it usually means that you already have mutated sebaceous glands and therefore hair follicles since utero, meaning they are super sensitive to not just steroid hormones, but also peptide ones like prolactin or insulin, just via defferent pathways. With those kind of mutations you need to dig a little deeper and counter direct sources of hair cycle disruption and inflammation. And the main sources are Wnt signaling pathway and PGD2.
PGD2 is both the main source of inflammation and Wnt activator. Like other prostaglandins, it can be easily countered by NSAIDs like aspirin without a need of using corticosteroids in most cases. I think the reduction of it must be a priority for most people with hairloss.
Wnt, which can also cause cancer and diabetes btw, unfortunately, cannot be inhibited directly apart from lowering PGD2. There is a direct Inhibitor, but it was only tested on rats, but successfully, which is good news.

All that is correct but to make things easier, if you bald from a young age, you are way too fucked and you shouldn't spread your genetic, so taking hrt and a vasectomy (because there are reports of mtf getting cis women pregnant) would eliminate the shitty genetics. Every young balding man should do that, same for woman who start thinning at young age. For us? It is too f*****g over but we can choose to not be selfish and stop spreading this genetics. Unfortunately humans are horrible creatures that wants to spread their genetics regardless if it is good or not, then their descendants will suffer because their parents were f*****g selfish and only care about them and what they want.

I rly f*****g hate when a bald f*** says 'oh no I dont want to take dutasteride might affect my fertility' just stfu up and get a vasectomy and stop that miserable genetic once and for all
 
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SavingMyHair

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Baldness literally destroys lives, especially at a young age, because it is apparently also considered a metabolic illness

". Early-onset Androgenetic Alopecia may also be associated with hormonal profiles, 5α-reductase enzyme activity, androgen receptor genes, and some susceptibility loci. Comorbidities investigated included MetS, cardiovascular disease, insulin resistance, dyslipidemia, and Parkinson’s disease. Men with early-onset Androgenetic Alopecia may have reduced treatment efficacy with drug like rosuvastatin, metformin or lisinopril for dyslipidemia, prediabetes, or hypertension. Additionally, young men with Androgenetic Alopecia tended to suffer from psychological issues such as anxiety and low self-esteem compared to those without hair loss."
 
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exwhyyou

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I also think that diet is super important, especially if you arent using anti-inflammatory drugs. I agree that you need enough protein, but IMO more than anything else you need to avoid inflammatory foods like sugars, caffeine, flour products and alcohol.
i just dont think the average person gets “enough protein” especially in todays day in age. you literally need to have your mindset on protein 24/7 to reach the ideal macros, anyone whose experienced with lifting/gains knows this as fact. you can’t expect to see elite results with hair unless you get 1g per pound of body weight daily. 150-200g daily for the average male is a pretty difficult task. i’m sure most of the people on this fourm are getting 50-100g a day and considering it adequate
 

SnortingFinasteride

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Any guy who keeps taking hrt is a trans in denial and needs help like vast majority of users here. The ones who took it for hair purposes dropped hrt after a while.
Very true. I dropped it as well after it began acting on my chest. Thought of getting raloxifen + hrt but what if raloxifen caused me hairloss as well ? Yeah this just ain't worth it tbh
 
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