Exploring The Hormonal Route. Hair=life.

[Adri23]

you did all the genetic tests you had to do now you only miss a scalp biopsy.Its minimal invasive and its really important you should do it asap.

Yes but no one is willing to do cuz apparently 'I dont need it' according to the doctors.

if i remember correctly you were recovering with clobetasol am i wrong?

Not sure about that but sometimes it helps with scalp aches

(lol i want a trhicosvope too) is it expensive?

No, it is cheap

 

[SnortingFinasteride]

I wish we could permanently destroy the androgen receptors in the scalp. Why are they there on the first place and why the f*** does biology decided that androgen could miniaturize hairs in some people? I hate biology....

Somehow destroying androgen receptors in scalp would not solve the problem of regrowing, only mantaining

The closest we got to this was high dose Bicalutamide. It still isn't a "cure"

 

[Ryuzaki hedeki]

You need to start hrt before puberty to prevent miniaturization so you can't pass as male

 

[sg2000]

You need to start hrt before puberty to prevent miniaturization so you can't pass as male

wtf so you want to become a woman

 

[Adri23]

Crown seems more oily, but overall looks good to me, apart from missing hairs. The colours look kinda faded tho, hard to tell if thats a dot or just a missing hair. Can you maybe take a video?

Will try to tale a video later

I have a digital microscope at home btw, and my scalp is a mess compared to yours, full of red dots and the texture is kinda crumbly.
I'll show tomorrow when i get home.

Used to have lot of inflammation too, in fact I have some in some small areas but not as bad as before. I cycle clobetasol propinoate, like a full week then 2-3 week rest and a maintenance of 3 times per week for a week and if there is no aches or redness I stop if for some time. It has been going good. However I dont know how much it is helping since I used clobetasol before and didnt have this healthy scalp. I think supplementing with many antioxidants and anti inflammatory stuff are helping more because it is the only thing I've changed from last year to now

 

[Adri23]

I don't think they measure mRNA expression (aka regulations) with biopsy on scalp tho, if there's no tumor at least. AFAIK, they mostly use electrophoresis, or some type of hybridization for that. Biopsy can spot autoimmune disorder tho, which is nice.

Yeah but I said that not tl see if those enzymes are upregulated but to see if you really still have Androgenetic Alopecia or not

 

[Adri23]

Somehow destroying androgen receptors in scalp would not solve the problem of regrowing, only mantaining

Yeah but at least maintaining, the only real way to regrowth as for right now are high dosages of oral min imo, but I rly rly hate the nasty hypertrichosis + I get sides when I go up to 5 mg per day. Maybe with 2.5mg 2 or three times a day it wouldnt give me the heart sides because it only happens the first hours when the 5 mg peaks which is waaay more than 2.5 mg peak so 3 times per day should soften the peak since oral min has short half life, but I don't want to look like a monkey(even 2.5 mg makes the hypertrichosis unbearable to my liking)

The closest we got to this was high dose Bicalutamide. It still isn't a "cure"

I think that paired with high dosage bica to cover the dht since u know bica isn't too good for dht. In the best world using enzalutamide would be better but ye, it is expensive

 

[sg2000]

No signs of Areata as for now, just miniaturization

tbh the majority of them are thick and strong

 

[sg2000]

@Adri23 didnt estradiol change somehow the gene expression in order to protect hair?

 

[Adri23]

tbh the majority of them are thick and strong

In some zones they are thick but others are very thin. But my hair look thin and terrible despite of using leave-in conditioners. I have tried many of them but my hair still look sh*t af...

@Adri23 didnt estradiol change somehow the gene expression in order to protect hair?

Maybe in some tissues but I don't know if it would on a scalp of a young person with Androgenetic Alopecia. The mutations in those scalps are too strong. That is why it is so difficult to treat Androgenetic Alopecia in young guys, we have very increased activity and mutations there, a bit of a mess if you ask me... A real curse. I rly think diminishing 5ar as much as possible + blocking the androgen receptor is the best bet for us, estradiol alone is not a privilege that us balding young people can enjoy, our destiny if we want hair is e2 + bica at moderate dosage + lot of dutasteride(which is expensive and hard to get tbh and unknown side effects at high dosages like 10 mg that has shown a complete nuke of 5 alpha reductase).

 

[Adri23]

By the way I am going to be doing an experiment that I will start next week which will consist in taking like 10-15 mg of chinese dutasteride powder in the MCT oil + BHT solution I made, and do a blood test in a month. I was using 4 mg before + 1 mg of avodart with zero reduction in serum DHT( still 22 ng/dl which is wild with a T of 21 ng/dl). Maybe the dutasteride is not fake and the bioavailability of my solution just suck, so I will do mega doses and see if at least my serum DHT tanks with the mega doses. If it does lower it this time it means it works and I would continue taking it for more time and see if it really makes a difference.

 

[sg2000]

By the way I am going to be doing an experiment that I will start next week which will consist in taking like 10-15 mg of chinese dutasteride powder in the MCT oil + BHT solution I made, and do a blood test in a month. I was using 4 mg before + 1 mg of avodart with zero reduction in serum DHT( still 22 ng/dl which is wild with a T of 21 ng/dl). Maybe the dutasteride is not fake and the bioavailability of my solution just suck, so I will do mega doses and see if at least my serum DHT tanks with the mega doses. If it does lower it this time it means it works and I would continue taking it for more time and see if it really makes a difference.

my dht was 22 ng dl on dutasteride before hrt and now after it it dropped to 5,0 ng dl.Do you think that im saved ?lol
however i want6 to try high dose dutasteride too but i need to get a job first cause now im brooke lol

 

[sg2000]

By the way I am going to be doing an experiment that I will start next week which will consist in taking like 10-15 mg of chinese dutasteride powder in the MCT oil + BHT solution I made, and do a blood test in a month. I was using 4 mg before + 1 mg of avodart with zero reduction in serum DHT( still 22 ng/dl which is wild with a T of 21 ng/dl). Maybe the dutasteride is not fake and the bioavailability of my solution just suck, so I will do mega doses and see if at least my serum DHT tanks with the mega doses. If it does lower it this time it means it works and I would continue taking it for more time and see if it really makes a difference.

however i think that Androgenetic Alopecia its an inflammatory process too so we can benefit from topical steroids anyway.
I think scalp inflammation is a fact and can cause hair loss.Before hrt my scalp was painful and after eating something more sugary itched now the pain is gone and the itch its waay lower

 

[Adri23]

my dht was 22 ng dl on dutasteride before hrt and now after it it dropped to 5,0 ng dl.Do you think that im saved ?lol
however i want6 to try high dose dutasteride too but i need to get a job first cause now im brooke lol

A lower DHT in blood is the right way to succeed but sadly it does not say much about the whole situation within tissues where DHT is made. For example dht can be reduced 92% with 0.5 mg daily dutasteride in serum but just ~51% in scalp. 2.5mg was like 96% in serum but ~79% in scalp. That is why serum does not say much. Also 0.5 mg dutasteride inhibit like ~50% 5ar1. I dont know how much 5ar1 2.5 mg inhibits but comparing the tissue dht inhibition of +28% I would guess the 5ar1 inhibition with 2.5 mg would be much higher from 0.5 mg to 2.5mg compared with the 5ar2 inhibition which is almost fully suppressed at 0.5 mg/day. 10 mg dutasteride would just nuke all the DHT but 2.5 mg is also a very good dosage considering that we dont know the risk of such mega doses long term.

however i think that Androgenetic Alopecia its an inflammatory process too so we can benefit from topical steroids anyway.

Ofc it is.

I think scalp inflammation is a fact and can cause hair loss.

100%

Before hrt my scalp was painful and after eating something more sugary itched now the pain is gone and the itch its waay lower

Yes diet is also important for inflammation as long as you dont eat much trash you are good. Like you can keep doing cheat meals as long as it is not ur daily basis diet.

I saw a lot of improvements of inflammation with supplements, mostly antioxidants that also works as anti inflammatory. My scalp looks way healthier now than before even using clobetasol my scalp has never been this good, so supplements could be a good one too(and most of them are not even expensive).

 

[SnortingFinasteride]

By the way I am going to be doing an experiment that I will start next week which will consist in taking like 10-15 mg of chinese dutasteride powder

Dude at least send some to a lab to check if it's actually dutasteride. Don't just take chinese stuff hoping that it's geniune dutasteride come on now be smart

 

[Adri23]

Dude at least send some to a lab to check if it's actually dutasteride. Don't just take chinese stuff hoping that it's geniune dutasteride come on now be smart

idk i have took it a while ago and never died. Also lena buy products to them and tested and they are real. At least it is not lethal poison cause i have used like 4 mg per day for month. I'd love to send it to a lab to get tested but money issues u know

 

[losingbattle88]

How does asprin help hair ?

Yeah but at least maintaining, the only real way to regrowth as for right now are high dosages of oral min imo, but I rly rly hate the nasty hypertrichosis + I get sides when I go up to 5 mg per day. Maybe with 2.5mg 2 or three times a day it wouldnt give me the heart sides because it only happens the first hours when the 5 mg peaks which is waaay more than 2.5 mg peak so 3 times per day should soften the peak since oral min has short half life, but I don't want to look like a monkey(even 2.5 mg makes the hypertrichosis unbearable to my liking)

I think that paired with high dosage bica to cover the dht since u know bica isn't too good for dht. In the best world using enzalutamide would be better but ye, it is expensive

idk i have took it a while ago and never died. Also lena buy products to them and tested and they are real. At least it is not lethal poison cause i have used like 4 mg per day for month. I'd love to send it to a lab to get tested but money issues u know

Get a job u bum.

 

[Adri23]

Get a job u bum.

getting a job here as student is harder than asking you to stop jerking off, almost impossible

 

[losingbattle88]

getting a job here as student is harder than asking you to stop jerking off, almost impossible

Havent jerked it in days. Im saving my semen for someone special.

 

[Adri23]

Havent jerked it in days. Im saving my semen for someone special.

Oh yeah you was saving it for the hair regrowth protein shake, almost forgot!