0.03/0.04mg Of Finasteride. Please Help Me With This Research Project.

[Afro_Vacancy]

So you're saying the scalp may be more sensitive to Finasteride? Why would that be?

If Finasteride saturates the skin before saturating the bloodstream.

 

[stump]

If Finasteride saturates the skin before saturating the bloodstream.

Do you have any proof of that?

 

[Afro_Vacancy]

Do you have any proof of that?

Scroll to post #11
https://www.gourmetstylewellness.com/interact/threads/finasteride-low-doses.99341/?p=1335466&viewfull=1

 

[NormanNorwood]

Ok so I left a 1mg pill in a very small amount of 37.5% rum I had at home overnight.

I not sure what think. Initially it broke down very quickly and by 3 hours the water just looked very cloudy.

I checked again this morning but doesn't seem to be much difference.. Looks mostly dissolved, water is almost cloudy and some of the material has settled at the bottom of the little cup.

Going to leave it for the rest of the day. What do you think?

So there first photo is 5:30pm. The second is 5:45pm (already very dissolved and hopeful) and the third photo is 8:30pm. More dissolved, cloudy liquid. Will update when I'm home.

 

[Afro_Vacancy]

Leave it in for a couple days, it's a good sign i think.

I'd still crush it with the pill cutter and then the mortar and pestle just to be safe, but it looks like the alcohol will finish the job.

 

[NormanNorwood]

Leave it in for a couple days, it's a good sign i think.

I'd still crush it with the pill cutter and then the mortar and pestle just to be safe, but it looks like the alcohol will finish the job.

I'll leave it in over the weekend and see how it goes. Do you think maybe I should have used more rum? Such a small amount may already have been fully saturated meaning more finasteride can't be dissolved?

If not stronger alcohol could be the answer. If it were in a bottle I could vigorously shake it which would probably help?

I'm sorry I have so many questions. I just want to be really thorough about this is all.

 

[whatevr]

I crushed two 5 mg finasteride pills and chucked them into a bottle of minoxidil and they dissolved within 90 minutes. Probably depends on the formulation though.

 

[NormanNorwood]

I crushed two 5 mg finasteride pills and chucked them into a bottle of minoxidil and they dissolved within 90 minutes. Probably depends on the formulation though.

Yeah probably is the formulation. I don't really want to drink minoxidil though haha.

My hairloss is pretty diffuse and I can't apply minoxidil all over my head. I got sides from applying it to the temples. Heart palpitations, shortness of breath etc etc.

 

[whatevr]

sh*t, my bad. I thought this was for topical application. Didn't read the OP thoroughly enough.

 

[NormanNorwood]

sh*t, my bad. I thought this was for topical application. Didn't read the OP thoroughly enough.

No worries If you have any ideas that may help me dissolve pills it would be useful please.

It must be safe for human consumption though.

 

[whatevr]

When I was considering buying Dutasteride powder to use orally my plan was to buy a litre of 96% ethanol and dissolve it in that. The higher grade the alcohol, the better. What you're using, the 37% rum is probably not going to be enough. You'd need at least 70% vodka.

http://www.ebay.de/itm/Original-Bre...138278?hash=item58d2770826:g:ywUAAOSwv-NWaTND

Buying something like this would be the best.
Pure Finasteride is soluble at 25 mg/ml in ethanol, but that is just the active ingredient. When you have a pill with binders and fillers in there that doesn't help. Definitely also want to pulverize it into a fine powder. I believe that, combined with the high grade ethanol should do the trick.

 

[Sanchez1234]

Maybe you are correct about the Oestrone and Estriadol levels but I was on Finasteride for 3.5 weeks. In that time my scalp itch and shedding completely stopped. I lost only 2 or 3 hairs in the shower.

Nice thread, i will be following it closely. When you are experiencing a stop in shedding and scalp itching, please let me now !

The science behind it is a wild guess right? You are hoping 0.03mg Finasteride will inhibit scalp DHT between 20% and 60% while serum DHT will remain even lower to ban the sides?

 

[GeorgeNatur]

Hi George.

Well if you're saying is correct then it is nice to know that my DHT and 5Reductase levels are normal.

Maybe you are correct about the Oestrone and Estriadol levels but I was on Finasteride for 3.5 weeks. In that time my scalp itch and shedding completely stopped. I lost only 2 or 3 hairs in the shower. Now 3 weeks off Finasteride shedding so much more again.

My hair is not oily, infact it's probably a little dry due to nizoral shampoo 2/3x a week. However my hair was never too oily, my hair was infact wonderfully thick and healthy. Not too oily or dry so I doubt Oestrone levels are too blame.

As for Estriadol and thyroid. I do not have a thyroid issue as of now, my doctor is keeping an eye on them as they are a tiny bit high but no concern.

I will look into what you have told me but for now because I did mange to stop shedding and itching with Finasteride I would like to try micro-dosing.

Also if Pgd2 blockers stop hairloss forever I think everyone would use them.

Thanks for your message, I will look into your information none the less

Oh and something else I would point out is that thyroid problems do not cause miniaturised hairs.

My hair is falling out receding in a classic male pattern baldness pattern. Thinning at the temples and sides with minituarised hairs only and diffuse thinning at the crown which are also all minituarised hairs.

See these 2 photos, The fist one is Hairloss from high Oestrone.
And the second one is from high DHT.

 

[GeorgeNatur]

Okay, serious question. What's the point of microdosing if it inhibits nearly the same exact amount of DHT as 1mg?? DHT inhibition is the cause of the side effects (and hair growth, obviously) you are experiencing. You're inhibiting nearly the same amount of DHT so you'd likely still experience the same exact side effects you had while using the higher dose. The amount you're taking shouldn't matter if the outcome of DHT inhibited is nearly the same.

The only thing I can think of is that with a smaller dose, your DHT would be inhibited for a shorter amount of time, kinda like you are spiking it from low to high and back again.. Your DHT levels would be low for a short period of time, which might explain why you'd get less side effects, but then again I don't see how this would affect your hair loss.

This doesn't make any sense. If the time your DHT is inhibited is independent of the amount you take, then you'd likely still see the same side effects since you're still inhibiting DHT by nearly the same amount. If it's not independent and a smaller dose doesn't inhibit your DHT for long enough then I doubt you'd see any progress in hair growth (and obviously no side effects) since your DHT will just shoot right back up faster than with a larger dose. The only positive to this microdosing that I can see is you'd save money if dosage is independent of the time DHT is inhibited, although Finasteride is dirt cheap to begin with so what's the point?

Very good the analysis,
only we have to say that high Pgd2 is responsible for Hairloss,(Dr G.Cotsarelis)

And high levels of Pge2 give regrowth (together with low Pgd2 levels).

And high levels of Pgd2 can stimulate high levels of DHT or high Estrogens.

 

[NormanNorwood]

When I was considering buying Dutasteride powder to use orally my plan was to buy a litre of 96% ethanol and dissolve it in that. The higher grade the alcohol, the better. What you're using, the 37% rum is probably not going to be enough. You'd need at least 70% vodka.

http://www.ebay.de/itm/Original-Bre...138278?hash=item58d2770826:g:ywUAAOSwv-NWaTND

Buying something like this would be the best.
Pure Finasteride is soluble at 25 mg/ml in ethanol, but that is just the active ingredient. When you have a pill with binders and fillers in there that doesn't help. Definitely also want to pulverize it into a fine powder. I believe that, combined with the high grade ethanol should do the trick.

Ok I will look into the ethanol. I was hoping for a weaker solution though as I don't want to put high concentration alcohol in my blood in the morning before work a few days a week haha.

You said buying dutasteride powder? I didn't realise that was possible, I wonder if you can buy Finasteride powder? I have a scale that can measure micro-grams I believe so that would be a lot easier..

 

[NormanNorwood]

Nice thread, i will be following it closely. When you are experiencing a stop in shedding and scalp itching, please let me now !

The science behind it is a wild guess right? You are hoping 0.03mg Finasteride will inhibit scalp DHT between 20% and 60% while serum DHT will remain even lower to ban the sides?

It will probably take me another week to acquire the alcohol and pipettes for administration but yea keep a close eye

Well it's not a wild guess, there was a study then where they tested Finasteride in micro doses and found that some inhibited alot scalp DHT but not as much serum DHT. It wasn't linear.

They never tested 0.03mg though and myself and @David_MPN believe this could be good for lowering scalp DHT and minimising serum DHT levels this hopefully avoiding sides.

 

[NormanNorwood]

@David_MPN

Struggling to find something that I can dissolve the Finasteride in that I can buy here in the UK.

Most things are either really expensive or not fit for human consumption (Everclear not available here) but then I chanced on this.

https://www.amazon.co.uk/gp/aw/d/B0...8&sr=8-1&keywords=ethyl+alcohol&pi=SY200_QL40

What do you think? It's only 100ml but I could dissolve 1x 5mg tablet in it and then mix with 650ml of water?

Then just take a 5ml dose every 2/3 days.

It's Ethyl alcohol which is fit for human consumption isn't it?

 

[Afro_Vacancy]

@David_MPN

Struggling to find something that I can dissolve the Finasteride in that I can buy here in the UK.

Most things are either really expensive or not fit for human consumption (Everclear not available here) but then I chanced on this.

https://www.amazon.co.uk/gp/aw/d/B0...8&sr=8-1&keywords=ethyl+alcohol&pi=SY200_QL40

What do you think? It's only 100ml but I could dissolve 1x 5mg tablet in it and then mix with 650ml of water?

Then just take a 5ml dose every 2/3 days.

It's Ethyl alcohol which is fit for human consumption isn't it?

Ethyl alcohol = ethanol, which is the alcohol you can drink.
Methyl alcohol = moonshine, that's the toxic alcohol that makes you go blind.
What are the other 3.5% in this product ... water?
Honestly, why not just use vodka? Didn't your solvent upthread work fine?

I would go over the polichem studies. We know for example that with respect to blood/serum DHT there is no point in using finasteride everyday as 5AR takes a long time (~2 weeks) to replenish the blood. But I thought there was evidence in the polichem studies that the turnaround time in the skin is much faster. In that case, 2.5 ml every day is better than 5ml every two days.

 

[NormanNorwood]

Ethyl alcohol = ethanol, which is the alcohol you can drink.
Methyl alcohol = moonshine, that's the toxic alcohol that makes you go blind.
What are the other 3.5% in this product ... water?
Honestly, why not just use vodka? Didn't your solvent upthread work fine?

I would go over the polichem studies. We know for example that with respect to blood/serum DHT there is no point in using finasteride everyday as 5AR takes a long time (~2 weeks) to replenish the blood. But I thought there was evidence in the polichem studies that the turnaround time in the skin is much faster. In that case, 2.5 ml every day is better than 5ml every two days.

Well I found this not long after my original message. It's vodka like you said..

http://www.thedrinkscellar.com/spirytus-luksusowy-96-5

This will work I'm sure. It's only 100ml though so I either mix it with water or just take a tiny dose of this from a pipette.

I suppose to make the maths easier I could put 3x 1mg tablets in. Each 1ml will be 0.03mg so I'd get 100 doses out of a bottle.

100ml for 3 whole tablets isn't a lot though so I really hope it dissolves properly.