23 Years Old, was in denial, shaved my head yesterday

Magz

New Member
Reaction score
2
EDIT NEW THREAD WITH RESULTS AND PICTURES:

http://www.gourmetstylewellness.com/interac...to-listen-Pics-included?p=1230326#post1230326

The following are numbered because after all of my research, I think I can say with certainty that male pattern baldness is caused by cranial pressure caused by poor blood flow to the scalp. The reasoning is also cited by more than one independent sources. I have begun a regime today, and will post back results. I am thinking of foregoing any medication/topical solutions except the vasodialtor minoxodil.

My girlfriend of over four years left about 7 months ago. When I say left, she just straight up peaced. It was probably the lowest time in my life, since I didn't even see it coming, even after I tried to prevent her from just taking a dump all over me.

1. I was obviously pretty distressed and I still feel the stress of that bull **** to this day.

2. I began working out like crazy.

In 4 months I had gained 20-25 pounds. Starting at 6 foot, 145 pounds, I was also low body fat percentage. With a 6 day a week regime, I was probably at a lower body fat percentage with substantial muscle growth. I was very h appy with the results, and continued to go.

3. It was about after that 4 month time, that I noticed my scalp was red, started to hurt, and that my hair was falling out. I was not using anabolic steroids; in fact, before I began working out religiously, my testosterone was in the 300-400 range, which is rather low. I'm sure after working out, it had increased pretty dramatically.

The pain, redness, flaking, itching was baffling. My head felt really tight. The pain was really terrible, that I stopped going to the gym 3 weeks ago and got a derm appointment immediately. At first I thought it was sebhorric dermatitis or folliculitis. How could I be balding at 23, right? I had a full head of hair less than a year ago, without any worry about losing hair. My brother hasn't lost any hair, and he works out just as much as I do. I was really depressed.

The dermatologist said he saw no inflammation (I don't know how, its clearly red in the photo), and he prescribed me a corticosteroid for the "inflammation."

4. The steroid helped reduce the redness, but I still felt the pain and itch. It was like my body was destroying the hair I had.

My hair was still shedding like crazy. The dermatologist said it was probably male pattern baldness, but I was unaware that male pattern baldness can feel like your hair is "burning off." Guess what, it can. If you feel this burning, your hair is most likely being destroyed due to inflammation, which causes poor blood flow.

So I shaved my head yesterday so the dermatologist could take a look today in the hopes that maybe he'd find an infection, since my head is still burning (but the redness is away). My scalp feels very tight.

I went to the dermatologist, and he said he didn't see any inflammation again, despite me telling him about the pain. Turns out, that these symptoms are supposedly experienced in 30% of cases, but there is only one study that has been done on the subject. Knowing the cause of it clearly explains why there is a burning sensation, and people can feel the areas that are going to fall out. These areas, for at least me, and through word of mouth of other forums that call this phenomena "mbp itch" is for the following chain reaction, which is somewhat circularly linked due to the role that DHT plays in the entire cycle:

1) Increase of DHT in the area either due to natural causes (as you age, DHT levels rise as you age) or outside influences (working out, increase in free testosterone, decrease in circulation in the area).

2) DHT accumulates the hair follicles, cause an immune system response, causing inflammation, causing a decrease in O2 levels, causing an increase in DHT levels.

3) Go back to 1

So I started reading everything I could on the subject. Here are my conclusions; I will try to cite everything with evidence, but you may need to google to find some on your own.

Conclusion:

1. Stress increases inflammation. Chronic stress can cause hair loss because of this inflammation across the body, called telogen effluvium. Once the inflammation is reduced, hair loss begins again.

In male pattern baldness, inflammation has a link without a doubt, but since this inflammation is completely localized to the galea and not the entire body, we only have hairloss in that area.

Blood flow is important in hair developement, because DHT ratio to Testosterone (which compete with eachother to bind to the same receptors), is swayed towards DHT when oxygen levels are less than ideal.

This article contains sources for the above claims: http://longevitypost.com/stop-fearing-testosterone-dht/

2. I increased my testosterone, much like someone one anabolic steroids. Since I increased my T, free T increases as well. Since my scalp was "tight," for whatever reason this may be, whether aging or stress, DHT ratios are elevated is obviously causing a negative response in my scalp causing pain and discomfort.

But why is DHT causing pain and discomfort here?

Turns out, DHT is the reason your skull expands:

http://www.ncbi.nlm.nih.gov/pubmed/18789604

The above article and one of its related article seem to say exactly this. It also explains the pattern of hairloss. It is also, subsequently, the one region that few people stretch through muscle exercises.

Also, it explains the "pattern" of hairloss. How can two follicles, less than 1 mm apart, be programmed differently? They aren't. That's why minoxidil works as a vasodiolator; by allowing blood flow to these areas to increase, we can restore this ratio of testosterone and DHT.

So in the chain what happened to me, disregarding my "stress," because stress just aggravates inflammation, doesn't cause it, it goes:

Increased testosterone -> DHT levels rise disproportionately to testosterone in my scalp -> my head starts to expand from the DHT -> my scalp gets "crushed," reducing blood flow -> DHT builds up -> my body begins to fight by inflaming the area -> DHT rises

And so on and so forth until it causes all my hair to remain dormant.

It also explains why all the current treatments work:

1. Minoxidil: increases blood flow to the regions that have poor blood flow. This stimulates growth because more oxygen is in the blood which in turn lowers DHT levels.

2. finasteride/Du: literally just removes a ton of DHT in your body, thus creating the correct ratio of T/DHT in your scalp. Its also explains why finasteride/Du don't fix the issue, and must be taken permanently, since hte blood flow remains the same, but hte DHT ratio is artificially corrected.

3. ru58841: protects the hair from DHT, and allows the follicle to survive.

4. Botox: This is the big one that points exactly to the reason male pattern baldness occurs. If male pattern baldness wasn't causes by low oxygen in the galea, botox would not cause hair to regrow at all. But it does, and its very successful, but only while the botox injection's effects are there.

5. Immunosupressors: if you take them, some people with male pattern baldness regrow hair.

http://www.ncbi.nlm.nih.gov/pubmed/7528050

This is because it stops the inflammation response from the immune system.

It all has to do with blood flow.

http://www.hairloss-research.org/blog/?p=102

I have been to MGH dermatology, and they clearly state that "despite what everyone is saying, blood flow and microinflammation caused by DHT has a direct effect on hair loss.

His full article can be found here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC199257/

I started doing my scalp exercises today. I can already feel my scalp feels better, and blood is rushing there. I will continue to update results with pictures.

What do you guys think?

 
Last edited:

Magz

New Member
Reaction score
2
I just started today at about noon.

Before noon, my head hurt a lot. I felt a lot of pain. For a couple hours now while i've been working and researching certain things, I've been doing scalp exercises, and I can certainly say my head feels so much better.

Why do we work out every part of our body except the scalp region? It makes no sense, and I will continue to do them for some time.

While I've been doing these exercises, I have been doing a lot of research about how to reverse the blood flow problem to the scalp, which is the issue.

http://www.hairloss-research.org/blog/?p=102

I checked this guy out. He is very prestigious. I took a look at other therapies involving VEGF (and its variants) and came across this paper and many others:

Heart disease essentially reversed, THIS IS THE CURE, SEE BELOW FOR WHY:
http://www.ncbi.nlm.nih.gov/pubmed/20600100
http://www.ncbi.nlm.nih.gov/pubmed/22378343


Basically what it says, is they took VEGF and two other vascular related genes, put them in a vector (a modified virus/bacteria), and injected them into the hearts of people suffering from some sort of ischemic condition, like heart disease. Turns out, there are no noticeable side effects (thats right, they inject this **** into the heart and theres no side effects, so its apparently rather safe), yet the heart basically creates brand new vascular pathways and basically revitalizes the region.

This is the same gene that Kiichiro Yano used in his study to promote an increase the quality of hair in mice. He wasn't even looking for this, he simply noticed this, and although it said he was trying to make a topical form of this, there's no further evidence of what happened to his trials that I can find, and this was in 2003. He is still at MGH, so perhaps I could reach out to him, but I might not need to.

So it concludes that we can clinically prove that hair loss is attributed to blood restriction. We can actually already conclude that because of the botox study; it is extremely conclusive actually.

There is NO REASON that botox would cause hair growth in places that were bald unless it had something to do with the muscles/tension in the area. We already know the hairs are just dormant, not actually dead (maybe dead after years of DHT abuse, but I haven't looked that up yet so I cannot comment whether they can be permanently destroyed).

I say muscles/tension because its true that the galea is not a muscle (its rather a fibrious tissue, much like cartlage), but the muscles off the head run underneath the galea, and this tension restricts blood flow, as any tensed muscle will. Botox releases this tension, which in turn promotes blood circulation, and thus, the DHT is restored to its natural ratio and the immune system doesn't target hair follicles in these DHT buildup areas (which causes the inflammation due to immune response).

Counter-argument

I am a rational guy. I solve problems, and to solve an issue the right way, you must always try and counter-argue yourself.

There is only two counter-arguments to the above proposed that I can see, and both are related.

1) Hair transplant surgery is a permanent modification, and DHT will not effect these 'donor' follicles.

I was trying to find a source that says this, but the truth of the matter is that if you look up this question there is never any real scientific evidence to back it up, and whenever they say it, they always say "but we usually recommend the person stay on finasteride and minoxidil.

2) DHT stricken follicles implanted elsewhere still die. This is said to not be true, but depends on how damaged the stricken follicle is.

Answer and need help:

So we can literally figure out how to make the right gene replacements to get this done. I was doing some research, and its somewhat viable and not that costly for me to try and create the correct vector to try and do gene replacement on myself. I know quite a few doctors personally, and they could administer it to me without a problem.

The only thing is, si that I don't know enough about what EXACTLY I need to do it. I know I can get the correct genes (cDNA) from a company to express the receptors, and I know I can get a vector to infect the host cells from another company using the cDNA I got from the first company, and then I can inject the virus into my scalp area.

But there's so many questions about it that I need answered. If anyone knows someone in this field, say as soon as possible, because I'm ready to put an end to this war. Its obvious that they know the REAL reason behind male pattern baldness. Its too profitable for them not to.

So if anyone knows someone, tell me quickly, and I will continue to find someone in the meantime.



So summary up to this point:
The evidence is overwhelming at this point that

- - - Updated - - -

Update:

I continued to do scalp exercises today, and can still feel the benefits of it.

As far as research goes, I think I have found a pre-packaged adenovirus that will cause VEGF expression in the genes of the fibrous tissue of the scalp:

http://www.vectorbiolabs.com/Recombinant-Adenovirus/1437/Ad-VEGF-R1/VEGF/VPF-receptor

I believe this is exactly what I would need to test out my claim, but I am wary of continuing without gaining some medical advice from someone who

The advantages of this adenovirus is that it does not change your cell's DNA, but adds a new set of genes separate from the host's DNA. This does not mean that results would not be semi-permanent since vascular growth would have already occurred by the time these genes are no longer present due to the replication of the cell.

According to this article, this vector works safely and well in epithelial tissues, which the scalp contains:

http://link.springer.com/chapter/10.1007%2F1-4020-5955-8_2#page-1

If anyone knows someone who would have an idea about how I can start my own personal trial, I would like to know as soon as possible. If not, any other comments/questions are appreciated.
 

Magz

New Member
Reaction score
2
Its been a little less than a week since I started vigorously trying to increase subcutaneous blood flow to the area of my scalp. I essentially do scalp exercises/massages at any part of the day that I can.

Since then, I can feel the difference in my scalp. Also, since I've started, I noticed significant vellus hair growth along the hairline which I have lost complete once i started male pattern baldness about 2-4 months ago. Inside the hairline, the hair seems to be filling in as well. This is very promising to me, since before I started the exercises, I had no vellus growth along my original hairline. Inside my hair, I can see terminal hairs beginning to sprout.

I will be taking pictures every week to show my progress. Thursday marks a week, so I will post my original (baseline) photo, and my one week update on thursday.

I have talked to a doctor who is a friend about the VEGF adenovirus injection, and he is on board to test on me. I will update with any progress I have on that, but it seems that scalp exercises may actually be a natural way to stimulate VEGF naturally (since exercising the muscles increases subcutaneous blood flow in the area around muscles that are used, which in turn stimulates VEGF).
 

isishearmyplea

Experienced Member
Reaction score
42
minoxidil does not grow hair because of its vasolidating effects. That paper suggesting DHT expands your skull is nothing but a hypothesis, so yeah scalp exercise might help you with your pain etc but i dont think it will do much for male pattern baldness.
 

Magz

New Member
Reaction score
2
Hey thanks for responding guys. First to clarify some things:

'minoxidil does not grow hair because of its vasolidating effects.'

They say they don't know what causes Minoxidil to work. That's complete bull in my opinion, or rather misleading. It is clearly because it allows the blood supply to the hair follicle to widen, and thus increases oxygenation (which restores DHT/free-T ratios). Other vasodiolators may not increase the oxygenation. It also explains why Minoxidil only works on younger men, who have only experienced hair loss within the last 5 years: these subjects still have blood supply going to the follicle and the follicle is still attached/nearby its blood vessel.

When monoxidil doesn't work, it is not an issue with the patient needing to widen the blood flow to the follicle, but rather grow new blood vessels to the hair follicle.

This is why the botox injections seem to work; increasing blood supply by causing less restriction on the blood vessels to those follicles.

"
That paper suggesting DHT expands your skull is nothing but a hypothesis"

Androgens have been established as the primary culprits of bone remodeling regulation. Messing up the balance of androgens has a negative effect on bone remodeling. This is a fact, not a hypothesis.

http://www.asiaandro.com/archive/1008-682X/5/148.htm
http://www.ncbi.nlm.nih.gov/pubmed/15180950

There are many other clinical studies that can point to this.

" scalp exercise might help you with your pain etc but i dont think it will do much for male pattern baldness."

The male pattern baldness area (teh scalp), indicates that this is an locale issue, not a genetic issue. It makes no sense for 2 hair follicles 2 mm apart to express different genes unless there were an environmental factor.

Just like the rest of your body, your scalp needs ample blood flow. If you don't, the blood vessels start to shrink, until they cease to exist. If you don't work out your bicepts, the blood vessels become smaller and smaller, and as such, so do the cell groups in the area.

My male pattern baldness started as soon as I started working out hardcore. I also noticed that the hair on other parts of my body became thicker and more prominent. This is definently due to the fact that my blood vessels have grown (
angiogenesis). It is also supported by many papers published in the last ~5 years; VEGF, the primary regulator of angiogenesis, directly effects hair thickness/miniaturization. It also explains why there is a pattern to male pattern baldness: the galea is not a muscle, and thus angiogenesis is not naturally occurring in that region.

This is supported by the reason for hair miniaturization: the hair follicle moves away from the dermal papillae, thus causing less blood flow (and oxygen), and causing the hair growth cycle to be shorter. With angiogensis, we could increase the size of the blood vessels to the follicle, and length the growth cycle. This is known, and is how minoxidil works (though artificially, it does not perminently effect the blood vessels).

By working out muscles near the scalp, VEGF should be released.

This is also supported by the fact that if you cut your scalp in an area that is experiencing male pattern baldness, a lot of times the area around that cut no longer exibits male pattern baldness symptoms. Go figure that one out (it regrows blood vessels in the damaged area!!!). It also explains why hair transplants work; there is trauma to that area which causes angeogensis.

My Update:

I had a biopsy a little over a week ago. It c ame back as positive for miniturization, but it also came back positive to Telogen Effluvium. This means more than 25% of my hairs are sitting in the resting phase. This makes my prognosis a little bit different, since I may notice a lot of my hair come back because it didn't actually miniturize. I'll update with pictures this week to show 2 weeks.

As far as visually, I can see my hair start to fill out. its still thin, but my hair isn't falling out anymore like it was. There's no more pain, and my scalp feels much more flexible. I would say everyone should be trying this for the simple fact that it must have benefits, just like going on a 30 minute jog.

The exercises I do are 2, and I do some other things.

1. Raise eyebrows as high as possible, and hold until it burns a little bit.
2. Pull ears "back" (like wiggling your ears, its hard to master but feels like your smiling at the back of your head). Hold This one.

I alternate between these two. Periodically, I will also massage my scalp, pretty roughly; not too roughly. I do this sometimes while holding the exercises, other times after the exercises, but just do it. Push the blood around.

I also do this in the shower with some baby oil. Helps to moisturize the skin.

Thanks again for the responses guys!
 

Magz

New Member
Reaction score
2
Hey Guys, quick update if there's anyone out there still reading:

I ended up going on min and finasteride. Started getting some bad shedding.

As for as my proposed idea, I was able to contact some researchers who were able to create a VEGF gel that statistically increased follicular area almost immediately. The VEGF gel is actually pretty simple that almost anyone could make it, so once I get all of this figured out (probalby about a week), I can post how to make it. It's rather expensive to make I believe (be about 1000 dollars for 6 months), but that's because I would have to buy the VEGF165 protein from a manufacturer instead of cultivating it in a lab (by injecting the RNA sequence into EColi and then harvesting the proteins produced in culture).

This researcher, and other's who have used his work as a source, feel that VEGF expression is the root cause of male pattern baldness, not DHT. This is because VEGF expression is dramatically decrease in the presence of DHT/low oxygen environments, and that DHT attaches to the follicle in the area that blood vessels would have formed around the hair follicle if VEGF were being produced adequately.

This is also the reason they believe minoxidil works (increasing VEGF expression, albeit through a janky chain of events).
 

Magz

New Member
Reaction score
2
Update with Progress Pics:

http://www.gourmetstylewellness.com/interac...to-listen-Pics-included?p=1230326#post1230326
 

LosingHairIsNotFair

Established Member
Reaction score
46
Does Telogen Effluvium accelerate male pattern baldness? Because I think it is totally possible that I have a bit of Telogen Effluvium. I have a chronic anxiety disorder, so...
 
Top