AA cured.

[IDW2BB]

One down, a couple to go.

http://www.ncbi.nlm.nih.gov/pubmed/25129481

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.

Xing L1, Dai Z2, Jabbari A2, Cerise JE3, Higgins CA4, Gong W4, de Jong A4, Harel S4, DeStefano GM5, Rothman L4, Singh P4, Petukhova L4, Mackay-Wiggan J4, Christiano AM6, Clynes R7.



Author information









Abstract

Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies (GWAS) implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis. Here, we show that cytotoxic CD8+NKG2D+ T cells are both necessary and sufficient for the induction of AA in mouse models of disease. Global transcriptional profiling of mouse and human AA skin revealed gene expression signatures indicative of cytotoxic T cell infiltration, an interferon-γ (IFN-γ) response and upregulation of several γ-chain (γc) cytokines known to promote the activation and survival of IFN-γ-producing CD8+NKG2D+ effector T cells. Therapeutically, antibody-mediated blockade of IFN-γ, interleukin-2 (IL-2) or interleukin-15 receptor β (IL-15Rβ) prevented disease development, reducing the accumulation of CD8+NKG2D+ T cells in the skin and the dermal IFN response in a mouse model of AA. Systemically administered pharmacological inhibitors of Janus kinase (JAK) family protein tyrosine kinases, downstream effectors of the IFN-γ and γc cytokine receptors, eliminated the IFN signature and prevented the development of AA, while topical administration promoted hair regrowth and reversed established disease. Notably, three patients treated with oral ruxolitinib, an inhibitor of JAK1 and JAK2, achieved near-complete hair regrowth within 5 months of treatment, suggesting the potential clinical utility of JAK inhibition in human AA.

 

[hellouser]

How about a cure for the other 99% of hair loss sufferers?

Fvcking hell, it's like society doesn't want male pattern baldness to be solved and we're meant to be miserable forever.

 

[IDW2BB]

How about a cure for the other 99% of hair loss sufferers?

Fvcking hell, it's like society doesn't want male pattern baldness to be solved and we're meant to be miserable forever.

I agree!


There is something to be said for following a researcher (Angela Christiano) who's mission was to find a cure for AA and finally see that dream realized!
How much joy there must be in her heart and how grateful AA suffers must be.

Can't wait till it happens for us.

 

[resu]

I agree!


There is something to be said for following a researcher (Angela Christiano) who's mission was to find a cure for AA and finally see that dream realized!
How much joy there must be in her heart and how grateful AA suffers must be.

Can't wait till it happens for us.

And this is all it took.

 

[EvilLocks]

How can you call it a cure with 3 people being treated? and what do they know about side effects? surely this is great news for AA sufferers (and i'm jealous as hell) but i think it's a little early calling this the cure for AA

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Can't wait till it happens for us.

Like that's gonna happen. male pattern baldness is much harder to crack. It won't happen until we are dead or too old to care.

 

[IDW2BB]

How can you call it a cure with 3 people being treated? and what do they know about side effects? surely this is great news for AA sufferers (and i'm jealous as hell) but i think it's a little early calling this the cure for AA

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Like that's gonna happen. male pattern baldness is much harder to crack. It won't happen until we are dead or too old to care.

http://www.ncbi.nlm.nih.gov/pubmed/25129481

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.

Xing L1, Dai Z2, Jabbari A2, Cerise JE3, Higgins CA4, Gong W4, de Jong A4, Harel S4, DeStefano GM5, Rothman L4, Singh P4, Petukhova L4, Mackay-Wiggan J4, Christiano AM6, Clynes R7.



Author information









Abstract

Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies (GWAS) implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis. Here, we show that cytotoxic CD8+NKG2D+ T cells are both necessary and sufficient for the induction of AA in mouse models of disease. Global transcriptional profiling of mouse and human AA skin revealed gene expression signatures indicative of cytotoxic T cell infiltration, an interferon-γ (IFN-γ) response and upregulation of several γ-chain (γc) cytokines known to promote the activation and survival of IFN-γ-producing CD8+NKG2D+ effector T cells. Therapeutically, antibody-mediated blockade of IFN-γ, interleukin-2 (IL-2) or interleukin-15 receptor β (IL-15Rβ) prevented disease development, reducing the accumulation of CD8+NKG2D+ T cells in the skin and the dermal IFN response in a mouse model of AA. Systemically administered pharmacological inhibitors of Janus kinase (JAK) family protein tyrosine kinases, downstream effectors of the IFN-γ and γc cytokine receptors, eliminated the IFN signature and prevented the development of AA, while topical administration promoted hair regrowth and reversed established disease. Notably, three patients treated with oral ruxolitinib, an inhibitor of JAK1 and JAK2, achieved near-complete hair regrowth within 5 months of treatment, suggesting the potential clinical utility of JAK inhibition in human AA.

 

[hellouser]

How can you call it a cure with 3 people being treated? and what do they know about side effects? surely this is great news for AA sufferers (and i'm jealous as hell) but i think it's a little early calling this the cure for AA

There's been more than three people; the Yale University used Xeljanz (similar to Ruxolitinib) to treat one patient, which was also used a couple years back on mice AS WELL AS on humans by Dr. Angela Christiano.

Like that's gonna happen. male pattern baldness is much harder to crack. It won't happen until we are dead or too old to care.

It will happen soon enough. You just need to be realistic about it. Could be tomorrow or could be 10 years from now.... but it WILL happen soon. Dr. Lauster's team is pretty damn close... if not there already (they keep a lot of info private). Don't forget about Follica, Histogen and especially Replicel's work with Japan's new legislation.

Better days are ahead.

 

[2bald2young]

It will happen soon enough. You just need to be realistic about it. Could be tomorrow or could be 10 years from now.... but it WILL happen soon. Dr. Lauster's team is pretty damn close... if not there already (they keep a lot of info private). Don't forget about Follica, Histogen and especially Replicel's work with Japan's new legislation.

Better days are ahead.

10 years doesn't sound very soon. http://www.dailymail.co.uk/health/a...ow-worlds-hair-follicle-using-stem-cells.html found this link and it looks like he is probably going to be a liar os I don't expect to much from him.

 

[hellouser]

10 years doesn't sound very soon.

Because it isn't. If it's 10 years then I'll have the pleasure of living a life where society has deemed me worthless because of my hair throughout my 20s and 30s.

Fvck this disease.

 

[2bald2young]

Because it isn't. If it's 10 years then I'll have the pleasure of living a life where society has deemed me worthless because of my hair throughout my 20s and 30s.

Fvck this disease.

Ok but I am really confused with all these german scientist like lauster and jahoda. Are they really close or just lying bucause if you look at the article I posted he lied.

 

[resu]

Because it isn't. If it's 10 years then I'll have the pleasure of living a life where society has deemed me worthless because of my hair throughout my 20s and 30s.

Fvck this disease.

Regenerative medicine keeps progressing, if we can have new follicles created on a lab in the future, maybe in your 40's you'll be able to look like you did in your 20's, not that far fetched.

 

[hellouser]

Ok but I am really confused with all these german scientist like lauster and jahoda. Are they really close or just lying bucause if you look at the article I posted he lied.

Lauster is German. Jahoda is British (I believe). They really are close. Lauster is able to create micro follicles already... now just needs to create terminal hair growing follicles. Are they liars? No.... but they do exaggerate a lot if only to stroke their own ego.

I think it's high time that all of them shut the fvck up and give us something substantial rather than constantly regurgitating the same 'within 5 years' bullsh*t. It's a god damn insult to hear that.

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Regenerative medicine keeps progressing, if we can have new follicles created on a lab in the future, maybe in your 40's you'll be able to look like you did in your 20's, not that far fetched.

Do you know how long these researchers have been masturbating over cells and follicles? 40 years. FOURTY fvcking years and they've got JACK SH*T to show for all their 'efforts'.

I swear, if these guys had the problem solving skills like the tech guys in silicon valley, we'd have had the cure 40 years ago.... but since that's not the case and since this isn't a woman's problem (generally speaking), it should be no surprise that we are where are today.

Good thing these guy's don't depend on results to keep their job. They can work as slow as they like and paychecks will still come in.

 

[Muzzle]

Do you know how long these researchers have been masturbating over cells and follicles? 40 years. FOURTY fvcking years and they've got JACK SH*T to show for all their 'efforts'.

I swear, if these guys had the problem solving skills like the tech guys in silicon valley, we'd have had the cure 40 years ago.... but since that's not the case and since this isn't a woman's problem (generally speaking), it should be no surprise that we are where are today.

Good thing these guy's don't depend on results to keep their job. They can work as slow as they like and paychecks will still come in.

Money spent on military expenditures : 1.7 trillion dollars
Money spent on hair loss cure : 15-20 million dollars maybe, lol

Honestly, i dont expect a cure for hair loss

 

[benjt]

I think it's high time that all of them shut the fvck up and give us something substantial rather than constantly regurgitating the same 'within 5 years' bullsh*t. It's a god damn insult to hear that.

Which researchers said that, except for the ones collecting funds for their private companies? None. It's the media that wants to generate clicks saying in every article "cure around the corner", which is never based on the statements of actual (and serious) scientists.

Do you know how long these researchers have been masturbating over cells and follicles? 40 years. FOURTY fvcking years and they've got JACK SH*T to show for all their 'efforts'.

Oh, they have a lot to show. Just nothing that helps male pattern baldness because - guess what - regeneration of vital organs, just to give one example, was of bigger priority. Which may suck for you and me but is totally understandable.

I swear, if these guys had the problem solving skills like the tech guys in silicon valley, we'd have had the cure 40 years ago....

Having worked both in the industry and being employed in research for some time now, let me point out the difference: What the guys in Silicon Valley are doing, in 99% of everything they make, is applied. Others, mostly universities and public research bodies, did the basic/fundamental research before. And that is what costs time and money. The Silicon Valley guys just take the theoretical results, which were much harder to obtain, and put them into practice. While at the same time, the companies in silicon valley have much bigger funds and much more manpower. How big is Lauster's or even Cotsarelis' group? Less than 10 people each, with only 3 to 4 core members each. Compare that to the silicon valley workforce.

Good thing these guy's don't depend on results to keep their job. They can work as slow as they like and paychecks will still come in.

Good thing you don't need to have a clue about actual research to make posts about it.
Research is suffering from insufficient funding and a lack in manpower. In general, only about 20% of the people who want to take a research position in public research can do so because there is simply a lack of open roles, again determined by funding. In other words, there could be 5 times more people in research if there was more funding. And before you start about all the money that is being spent on research: That is mostly for material costs like equipment. Funding for positions is much more limited than for material and equipment. And given that there are only positions for 20% of applicants, you can now guess that results - at least until hiring - do play a major role. No significant publications? No job for you.

As pointed out by a previous poster, compare research funding and military funding in the US. (military funding, by the way, being in turn invested in military research). Military research produced a lot of "results". Why? Because they got the money. Military budget in the US is 18% (!!!) of the whole federal budget. Research funding is at 3.4% of the federal budget which includes direct military research funding taking 70% of these 3.4%. All other fields of research are left with 30% of these 3.4% of the federal research budget, in other words about 1% of the federal budget goes into non-military research. Of this 1%, biology and health research receives a bit less than 30% Combining the military immediate research funding and the military funding together, the US military receives more than 20 times as much funding each year as primary civil research. Biology and health research receives a total of 0.3% of the federal budget, while being extremely costly.
Any questions?

But yeah, lazy scientists! Its always easy to blame when you don't have a clue.

 

[Armando Jose]

How about a cure for the other 99% of hair loss sufferers?

Fvcking hell, it's like society doesn't want male pattern baldness to be solved and we're meant to be miserable forever.

I understand you, a cure is fantastic but no more cases is good, prevention better tha cure, but what for prevention, it is no clear that finas or finas are not good and castration is very rude...., do you know any preventive treatment? BTW, the initial cause of common hairloss is not very well defined....

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How can you call it a cure with 3 people being treated? and what do they know about side effects? surely this is great news for AA sufferers (and i'm jealous as hell) but i think it's a little early calling this the cure for AA

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Like that's gonna happen. male pattern baldness is much harder to crack. It won't happen until we are dead or too old to care.

TIME, in 80% cases is the cure of Areata alopecia. AA is temporal i.... Nervous system is implicated surely

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Now I remember a guy, very smart with a high IQs,, of an English university that came out in the press saying that he had put the goal of curing baldness in a couple of years. There was a stir, ..., and now the only thing I see is the odd e-mail trying to sell their product. A shame ..... do you know the name of this person? Does he share his ideas in the forums?

When we know exactly the cause of alopecia, we can find a cure. Not before