willywonka
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Anyone have any comments on this before I try it on my head? What should I add to it? Caffeine?keto?adeno?
amino peptide complex?
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willywonka
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I've been changing my regimen a bit because I'm trying to get away from drugs. Also, my research into the biology behind loss has me curious about different approaches. I'll add my regimen to my profile. As for the "what is it" ; the protein is made up of a long chain of amino acids and when broken down to small chains its basicly considered a peptide at that point. Everyone knows protein is essential for hair growth. In fact its the most important! I plan on making a topical of it. I'm surprised at all the attention copper peptide has because the fact is that the coppers largely having an impact on the pigment cells and NOT the actual cells responcable for growth! using copper peptide is "beating around the bush" and not hitting the mark.
willywonka
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I was aware of this but its overall effect on our hairloss does not impress me. Have you seen any pictures from guys praisng the excellent improvement they have from cp? You won't ever because the stuff is just beneficial at most. What we need are products that put hair back on our heads, thats why we visit this site. I'll be sure to take pics of my scalp before I use it so as to document any improvement.1derphull said:
willywonka
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Noted, thanks1derphull said:
willywonka
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This Dutch study was conducted to determine whether Minoxidil has an inhibitory effect on certain enzymes involved in collagen synthesis.
Collagen is the most abundant protein in the human body and provides stability and, to some extent, elasticity. It’s a common structural protein that can be found in bone, skin, tendons and blood vessels and gives both strength and flexibility to these biological structures. The protein can be visualized like a rope twined from 3 smaller ropes. This triple-helix structure gives collagen its properties with each “rope†consisting of many amino acids in a string. The most common amino acids present are proline and glycin, but hydroxyproline and hydroxylysine can also be found, the latter two provide stability to the helix through hydrogen bonds and cross-linking.
In men suffering from androgenetic alopecia, male pattern baldness (male pattern baldness), it’s common to find perifollicular fibrosis (PF). Perifollicular fibrosis is when the collagen surrounding the follicle becomes rigid and forms a scar-like capsule around the follicle, cutting it off from circulation, and thus nutrition.
This condition is time dependent, the closer to the onset of male pattern baldness the less PF-affected follicles you will find. This then increases with the passing of time and is why long-term hair loss sufferers generally respond poorly to hair loss treatments.
PF can also occur from mechanical trauma, like when you pluck (or wax) your hair. When the anagen hair is pulled up from the follicle it can cause damage and formation of scar tissue. This is why frequently plucked hairs may grow smaller and smaller with time, because it gets less and less nutrition.
Collagen in these rigid formations often shows a higher content of hydroxyallysine cross-links. Hydroxyallysine is a modified version of hydroxylysine, hydroxylysine is in turn formed through the action of lysyl hydroxylase (LH).
When lysyl hydroxylase is inhibited, hydroxylysine isn’t formed, and therefore no hydroxyallysine is either, this then leads to an unstable triple-helix and weak collagen structures. This happens in scurvy, a condition caused by a lack of vitamin C, since lysyl hydrolyxase needs vitamin C to work.
It has been suggested that if LH could be inhibited to form less hydoxylysine in fibrose tissue, it would then become less rigid and would not cut off the nutrition to the follicle. Some scientists have postulated that minoxidil works through this exact mechanism, by stopping follicular fibrosis and by providing the affected follicles with more nutrition by stimulating angiogenesis (the formation of blood vessels).
This study examined minoxidil’s inhibitory effect on LH and how that affected collagen synthesis.
The study found that minoxidil reduced LH1 much more than LH2b and LH2b, and more than LH3 in a time- and dose-dependent manner in fibroblasts in vitro (in a Petri dish), but still had no effect on the formed hydroxyallysine cross-linked in the collagen.
A possible explanation for this is that minoxidil had the most suppressive effect on LH1, which is thought to have a preference for triple-helical lysine residues. To reduce the number of hydroxyallysine cross-links one needs to only reduce hydroxylation of lysine at the end of the proteins, the telopeptides, and very little in the helix itself. The hydroxylase thought to be responsible for this is LH2b, and that wasn’t suppressed as much by the minoxidil. One theory is that LH2b is only needed in small amounts to hydroxylate enough telopeptide lysine residues, and/or that it does so in conjuction with LH3.
The researchers concluded that it’s unlikely that minoxidil works by acting as an anti-fibroticum, but they did confirm minoxidil’s inhibitory effect on the lysyl hydroxylases. The study also provided additional information about the different lysyl hydroxylases, which may prove useful in further studies.
Collagen is the most abundant protein in the human body and provides stability and, to some extent, elasticity. It’s a common structural protein that can be found in bone, skin, tendons and blood vessels and gives both strength and flexibility to these biological structures. The protein can be visualized like a rope twined from 3 smaller ropes. This triple-helix structure gives collagen its properties with each “rope†consisting of many amino acids in a string. The most common amino acids present are proline and glycin, but hydroxyproline and hydroxylysine can also be found, the latter two provide stability to the helix through hydrogen bonds and cross-linking.
In men suffering from androgenetic alopecia, male pattern baldness (male pattern baldness), it’s common to find perifollicular fibrosis (PF). Perifollicular fibrosis is when the collagen surrounding the follicle becomes rigid and forms a scar-like capsule around the follicle, cutting it off from circulation, and thus nutrition.
This condition is time dependent, the closer to the onset of male pattern baldness the less PF-affected follicles you will find. This then increases with the passing of time and is why long-term hair loss sufferers generally respond poorly to hair loss treatments.
PF can also occur from mechanical trauma, like when you pluck (or wax) your hair. When the anagen hair is pulled up from the follicle it can cause damage and formation of scar tissue. This is why frequently plucked hairs may grow smaller and smaller with time, because it gets less and less nutrition.
Collagen in these rigid formations often shows a higher content of hydroxyallysine cross-links. Hydroxyallysine is a modified version of hydroxylysine, hydroxylysine is in turn formed through the action of lysyl hydroxylase (LH).
When lysyl hydroxylase is inhibited, hydroxylysine isn’t formed, and therefore no hydroxyallysine is either, this then leads to an unstable triple-helix and weak collagen structures. This happens in scurvy, a condition caused by a lack of vitamin C, since lysyl hydrolyxase needs vitamin C to work.
It has been suggested that if LH could be inhibited to form less hydoxylysine in fibrose tissue, it would then become less rigid and would not cut off the nutrition to the follicle. Some scientists have postulated that minoxidil works through this exact mechanism, by stopping follicular fibrosis and by providing the affected follicles with more nutrition by stimulating angiogenesis (the formation of blood vessels).
This study examined minoxidil’s inhibitory effect on LH and how that affected collagen synthesis.
The study found that minoxidil reduced LH1 much more than LH2b and LH2b, and more than LH3 in a time- and dose-dependent manner in fibroblasts in vitro (in a Petri dish), but still had no effect on the formed hydroxyallysine cross-linked in the collagen.
A possible explanation for this is that minoxidil had the most suppressive effect on LH1, which is thought to have a preference for triple-helical lysine residues. To reduce the number of hydroxyallysine cross-links one needs to only reduce hydroxylation of lysine at the end of the proteins, the telopeptides, and very little in the helix itself. The hydroxylase thought to be responsible for this is LH2b, and that wasn’t suppressed as much by the minoxidil. One theory is that LH2b is only needed in small amounts to hydroxylate enough telopeptide lysine residues, and/or that it does so in conjuction with LH3.
The researchers concluded that it’s unlikely that minoxidil works by acting as an anti-fibroticum, but they did confirm minoxidil’s inhibitory effect on the lysyl hydroxylases. The study also provided additional information about the different lysyl hydroxylases, which may prove useful in further studies.
willywonka
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What all that scientific talk is saying is the overall impact that minoxidil has is to restore the supply of nutrients to the hair. So My idea of delivering additional protein in the form of amino peptide to the hairs topically will only increase the results obtained from minoxidil.
willywonka
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It is well known that basic amino acids, fats and vitamins are essential for the growth of healthy hair. Undernourishment slows the growth rate of hair, and eventually leads to the hair thinning and then actually falling out. To put it simply
Petchsky
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Problem with your regimen is you will never know what is actually doing what, if you know what i mean.
That is true about minoxidil...many hair transplant Doctors advise to use minoxidil to help the recovery process after a transplant.
P.S What happend to your old profile? You can change your name you know...
That is true about minoxidil...many hair transplant Doctors advise to use minoxidil to help the recovery process after a transplant.
P.S What happend to your old profile? You can change your name you know...
willywonka
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I knew what was NOT working and that was 12 months wasted on big3 . Then I was dumping chemicals on my head and that seemed to make matters worse. Then bingo, I went this route and now my vellus hairline is sprouting! I'm def staying with this regimen.Petchsky said:
As for my profile, my isp 6.0 update seemed to crash my computer and (I'm actually using my laptop right now) and oddly they realized on the same day that I was late on payment (due to visa change ealier in the month) and they cut me off soooooo This site would not allow me to acces my profile and log in.
Shinyscalp23
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guys male pattern baldness is genetic..not a sign of bad health..if your hair follicles are undernourished--its simply because youre eating an undernourishing diet and may have an overall unhealthy lifestyle..and not necessarily our genes tho..there some food for thought--even tho u have thinning hair..some of it could be from abuse or lack of rest or eating poorly or all of the above in addition to the genetic time clock...which i think is more likely than you may really want to consider..but expecting copper peptides or biotin or anything else out there on the market to help with your male pattern baldness is just wishful thinking...u can create a healthy environment for your hair, prolong ts growth stage with minoxidil..and do whatever it takes to make your hair healthy..but the cause of the problem is a genetic hormonal predisposition...your extremely healthy hair could fall out from dht..just as well..your excesively thinning hair could thicken up with the right nutrients and supplements--in other words your thinning hair could be the result of a combo of things,and not just your male pattern baldness--even tho it looks like that...hair vitamins/nutrients/supplements and so on can regrow hair that fell out from reasons other than male pattern baldness but certainly iwont by themselves treat male pattern baldness if u follow me...adn this is just a possibility...there are many people ou tthere whoa buse themselves, hardly eat, do drugs and so on and have really thick heads of hair..so the nutirent thang can help but to what extent that depends..if you accelerate your male pattern baldness..there may only be so much nutrients can do to help you to begin with
willywonka
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This is trueShinyscalp23 said: