anti-androgens in minoxidil. Whats the consensus?

[ladysmanfelpz]

There's so much experimental science on hairloss, but usually it boils down to a few proven methods that work for most men. I know this has been discussed, but haven't really narrowed it down to the final answer. I know topical finasteride or dutasteride is pretty weak, but men try anyway, and if they are gonna spend the time adding minoxidil, might as well give the solution a little more firepower by adding an AA. So the things i've heard is that the drug will break down in a minoxidil solution and not be effective by the time or apply it (or at least a few days after you mix the solution).

So I'm just asking the proven methods here and if its worth my time. I tried minoxidil before but it stopped working and I got some sides so I went to finasteride to save what I had. I tried some dermarolling and S5 and what not, but now that I see my tiny vellus remain, I want to try and stimulate them with minoxidil again. I have some Dutasteride (both liquid caps and tablets) lying around and want to pick up some minoxidil and give it a shot. So can you mix directly in a minoxidil solution? Can I make another solution of dutasteride in a different vesicle and what vehicle would I use to administer?

And also if I got sides from 5% minoxidil, is it fine to use 2% minoxidil? I'm more interested in the effects of a topical AA anyway and maybe the dutasteride would be more stable in the alcohol solution and less prone to breakdown by the minoxidil :ermm:.

Thanks for speeding up my search guys and letting me know whats been tested.

 

[Kevincali]

I read they are working on micro-emuslions and even nano-emulsions so that that particles are small enough to penetrate. I do not see such available on the market yet. I also read that Finasteride is a type 1 inhibitor and it is type 1 that is more common in the scalp. dutasteride handles Type II - and type II is more common in the prostate - hence the use of dutasteride for prostate problems. Look up Finasteride on the Wikipedia for details. Though, it does seem like the wiki article was written by Merck.

 

[cthulhu2.0]

I read they are working on micro-emuslions and even nano-emulsions so that that particles are small enough to penetrate. I do not see such available on the market yet. I also read that Finasteride is a type 1 inhibitor and it is type 1 that is more common in the scalp. dutasteride handles Type II - and type II is more common in the prostate - hence the use of dutasteride for prostate problems. Look up Finasteride on the Wikipedia for details. Though, it does seem like the wiki article was written by Merck.

You're a little off there, let me elaborate. Finasteride inhibits 5 alpha reductase type II while Dutasteride inhibits both type I and type II. Type II DHT which is the product of 5 Alpha reductase II is present in the hair follicle and prostate whereas type I is present more widely throughout the body and in the brain. Hairloss seems to be related only to type II dht but dutasteride is more effective since it inhibits more type II dht but not the fact that it inhibits type I.