Ben said:
Since minoxidil does not block DHT then I dont think it would make much difference since minoxidil is a growth stimulator. If theres already a full head of hair theres no room for growth stimulation.
It may delay the onset of visible hairloss but not for more than a couple of years.
Is this actually a hairloss forum? I am shocked by the level of ignorance here. I have been on minoxidil for 15,5 years (and I use "only" 5-6% minoxidil; 10-15% minoxidil is apparently too strong for my follicles and it does more harm than good) and I know two guys, who have been using it successfuly for 20 years! No apparent loss of effectiveness. Or do you read the wisdom spread in the internet by certain senile narcisse called "Bryan"?
If you actually look at the studies of minoxidil, you will see that there are good responders and bad responders. Good responders can improve their hair count even after 5 years. It is the bad responders (or those, who simply don't use it regularly), who are responsible for the declining curve of hair counts. In one study, 80% patients (22 out of 27, who continued in the treatment) showed continuous improvement even after 4 years. And take into consideration that we speak about the increase of hair counts, not about the preservation of existing hair!
You can find studies of finasteride with a similar result, by the way. Hence some "wise guys" started to spread a mythology that finasteride stops working after 5 years. Yet, fortunately, we have the 10-years follow-up of Rossi et al. 2011, who finally demolished this rubbish. 65% men preserved their hair after the 1 year of use, 21% further improved between 5-10 years, and only 14% experienced some hair loss. Since the maximum regrowth in most users is achieved after 1-2 years, the curve of the AVERAGE hair count usually starts to decline after 2 years, because bad responders lose hair and the majority of good responders doesn't improve much significantly. That's it!
There is no reason to suppose that minoxidil works much differently than finasteride. 5% minoxidil may be weaker than finasteride, but it doesn't mean that stronger minoxidil concentrations cannot be more effective.
Sometimes I think over, what are such forums for. Yes, one can find some useful information here, one can find help, but much more frequently, these forums attract frustrated people, who don't respond to medications and report experiences that are characteristic for 0.5% users. These frustrated nuts then poison people's minds and take their hope.
And to the question of BaldBoy: If you start to experience first signs of hairloss, you should apply minoxidil on the whole area of your head that is normally affected by hairloss. If you are a good responder and if you apply it regularly, you can hold it practically indefinitely. Furthermore, even if it ceased to work, you can gradually uprade your minoxidil concentration. At worst, you can use the minoxidil+finasteride combo that should be effective in nearly all men - except the small minority of hopeless cases.