Association of Fibrosis in Bulge Portion with Hair Follicle Miniaturization in Androgenetic Alopecia

[Armando Jose]

It could be interesting read this recent paper

Association of fibrosis in the bulge portion with hair follicle miniaturization in androgenetic alopecia - PubMed

Association of fibrosis in the bulge portion with hair follicle miniaturization in androgenetic alopecia

pubmed.ncbi.nlm.nih.gov

Association of Fibrosis in Bulge Portion with Hair Follicle Miniaturization in Androgenetic Alopecia​

 

[Armando Jose]

If bulge stem cells dont reach to the dermal papilla, the hair probably get miniaturiced

 

[Pls_NW-1]

Now the million dollar question:
How can we prevent it!? Or even reverse it!? Lol

 

[John Difool]

Estrogen?

 

[Pls_NW-1]

Estrogen?

Bica? I mean it triples endogenous E levels.

E=hair | everyone should understand that.

 

[Armando Jose]

Now the million dollar question:
How can we prevent it!? Or even reverse it!? Lol

The question could be, what cause fibrosis? Maybe an inflammatory process?

 

[Pls_NW-1]

I think fibrosis is a natural process.
If there is no follicle, then the scalp gets "hard" lol.

Its a synergistic effect of the miniaturization.

Hope u understand what I mean.

The question could be, what cause fibrosis? Maybe an inflammatory process?

 

[waynakyo]

I posted a paper few days ago, scroll down, about current fibrosis drugs. (I also posted that same paper here )

 

[whatevr]

(PDF) Protective effects of taurine on human hair follicle grown in vitro1

PDF | Taurine is a naturally occurring β-amino acid produced by methionine and cysteine metabolism. It is involved in a variety of physiological... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

Pretty simple to counteract Fibrosis with Taurine (topical). Great at fighting TGF-beta. Too bad it makes me very tired and sleepy.

We should look at some others. Curcumin, NAC, also sorta work but in my experience worse than Taurine.

 

[Pls_NW-1]

What happens when you get a transplant in fibrotic scalp? Just a random question.

 

[Armando Jose]

What happens when you get a transplant in fibrotic scalp? Just a random question.

Probably will don't grow or don`t cycle

 

[Pls_NW-1]

Probably will don't grow or don`t cycle

So if you are a NW7, and if Tsuji works in a decade lol, it won't "cure" you? Sad

 

[John Difool]

I posted a paper few days ago, scroll down, about current fibrosis drugs. (I also posted that same paper here )

I saw that but can't find it. Do you mind replying with that link?

 

[Armando Jose]

I posted a paper few days ago, scroll down, about current fibrosis drugs. (I also posted that same paper here )

Certainly my friend,

https://www.gourmetstylewellness.com/interact/threads/association-of-fibrosis-in-bulge-portion-with-hair-follicle-miniaturization-in-androgenetic-alopecia.131242/#post-1945306

We need read the full paper

 

[ElToso]

I saw that but can't find it. Do you mind replying with that link?

https://www.gourmetstylewellness.com/interact/threads/drugs-and-targets-in-fibrosis-study-with-list-of-medications.131253/

 

[ElToso]

(PDF) Protective effects of taurine on human hair follicle grown in vitro1

PDF | Taurine is a naturally occurring β-amino acid produced by methionine and cysteine metabolism. It is involved in a variety of physiological... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

Pretty simple to counteract Fibrosis with Taurine (topical). Great at fighting TGF-beta. Too bad it makes me very tired and sleepy.

We should look at some others. Curcumin, NAC, also sorta work but in my experience worse than Taurine.

https://www.gourmetstylewellness.com/interact/threads/n-acetyl-cysteine-for-treatment-of-androgenetic-alopecia-in-men.126918/#post-1870123

A year ago you said the opposite

 

[balda]

@Armando Jose
cool. thanks.
have you had a chance to read the whole document?

 

[balda]

...trying to read more about bulge. check this out:
"
In 1992, Jaworsky and colleagues showed that biopsies of males and females with androgenetic alopecia showed the presence of activated T-cell infiltrates about the lower portions of follicular infundibula. Inflammatory cells infiltrated the region of the follicular bulge, the putative source of stem cells in cycling follicles. It was postulated that the progressive fibrosis of the perifollicular sheath might begin with T-cell infiltration of follicular stem cell epithelium and that the perifollicular fibrosis actually impairs hair growth.
"

ps. it's also discussed here on gourmetstylewellness.com:

https://www.gourmetstylewellness.com/interact/threads/genes-regulating-inflammation-stress-and-fibrosis-were-massively-overexpressed-in-all-androgenetic-alopecia-groups.121033/page-3#post-1776884

 

[Armando Jose]

@Armando Jose
cool. thanks.
have you had a chance to read the whole document?

I am interested

DEFINE_ME

 

[Armando Jose]

...trying to read more about bulge. check this out:
"
In 1992, Jaworsky and colleagues showed that biopsies of males and females with androgenetic alopecia showed the presence of activated T-cell infiltrates about the lower portions of follicular infundibula. Inflammatory cells infiltrated the region of the follicular bulge, the putative source of stem cells in cycling follicles. It was postulated that the progressive fibrosis of the perifollicular sheath might begin with T-cell infiltration of follicular stem cell epithelium and that the perifollicular fibrosis actually impairs hair growth.
"

ps. it's also discussed here on gourmetstylewellness.com:

https://www.gourmetstylewellness.com/interact/threads/genes-regulating-inflammation-stress-and-fibrosis-were-massively-overexpressed-in-all-androgenetic-alopecia-groups.121033/page-3#post-1776884

Yes, Jaworsky and Kligman in 1999

Characterization of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis - PubMed

Hair-bearing, transitional, and alopecic scalp from three males and one female with progressive pattern alopecia were examined. Ultrastructural studies disclosed measurable thickening of the follicular adventitial sheaths of transitional and alopecic zones compared with those in the non-alopecic...

pubmed.ncbi.nlm.nih.gov

Characterization of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis​

The data suggest that progressive fibrosis of the perifollicular sheath occurs in lesions of pattern alopecia, and may begin with T-cell infiltration of follicular stem cell epithelium. Injury to follicular stem cell epithelium and/or thickening of adventitial sheaths may impair normal pilar cycling and result in hair loss.