Rework24 said:
Since I am sure a company would not stop a product on the say so of one person I won't rise to the bait.
But I would happily shoot you where you stood if i thought you had contributed to them discontinuing flutagel.
It was a great product.... for me anyway, like any drug being taken for something its not actually meant for people will react, but thats just tough on them! Why should the people who are not suffering the side effects and getting the benefits lose out?
Like most of the 'newer' hair loss drugs around, there is always risks and the individual should have the option to hedge his own bets!
Rework,
I currently use Genhair's flutamide (at 4 months) and have seen reduced hair loss. I'm curious; how long were you on Sinere's Flutagel? How long were you on Genhair's flutamide?
BTW. It's unlikely that Bryan's handwringing motivated Sinere to take Flutagel off the market. It's far more likely that they took it off the market after receiving negative feedback from users regarding its side effects. Holster your pistol.
Other potential topical AAs:
Cyproterone acetate in an alcohol solution. CA is given in large doses to male sex offenders. Taken orally, it reduces free testosterone (by suppressing leutinizing hormone) and interferes with androgen binding to androgen receptors. Some studies have shown that topical CA reduces sebum output, which suggests that it might be effective against male pattern baldness, but I'm not aware of any studies measuring its effect on male pattern baldness directly. Not sure I'd recommend this. I've never seen reports, negative or positive, of any male pattern baldness users who have tried it.
RU58841. You're probably familiar with this one. Problems with RU include its high cost, relative unavailability (apparently a lab in China is the only current supplier), instability and consequent unreliability (some purchasers report having received "bad" batches of RU from the Chinese supplier). Another potential problem is its questionable long-term efficacy. Some long-term studies have stated that RU58841 loses effectiveness (maintenance or regression of RU-induced hair gains) after one year.
Curcumin. Might be an effective androgen receptor downregulating agent. Instead of exerting AA effects by blocking androgens from binding to the AR, like cyproterone or RU58841, curcumin actually reduces the amount of AR. Plenty of in vitro evidence, but I'm not aware of any in vivo studies. (It's only potentially effective orally for this purpose if taken with piperine, an extract of black pepper, which has been shown in at least one study to dramatically increase the bioavailability of oral curcumin in humans).
